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Abnormal attachment of sugar to BACE1 enzyme leads to formation of Aβ plaques in the brain

Researchers at the RIKEN-Max Planck Joint Research Center in Japan have demonstrated that hallmark symptoms of Alzheimer's disease can be reduced when sugars are prevented from binding to one of the key enzymes implicated in the disease. The new findings, reported in EMBO Molecular Medicine, show that abnormal attachment of a particular sugar to the enzyme BACE1 is a critical factor leading to the formation of Aβ plaques in the brain, and that plaques were reduced and cognitive performance improved when this action was prevented in mice through loss of the enzyme GnT-III.

17 Jan 2015

Researchers gain new insight into fragile X syndrome

Scientists have gained new insight into fragile X syndrome -- the most common cause of inherited intellectual disability -- by studying the case of a person without the disorder, but with two of its classic symptoms.

17 Jan 2015

MD Anderson honored with top science and technology award in China

The University of Texas MD Anderson Cancer Center was presented the People's Republic of China International Science and Technology Cooperation Award at a ceremony held Jan. 9 at Beijing's Great Hall of the People.

16 Jan 2015

FDA grants orphan drug status to NBI-77860 for treatment of congenital adrenal hyperplasia

Neurocrine Biosciences, Inc. announced today that NBI-77860, a proprietary corticotropin releasing factor 1 (CRF) receptor antagonist, has been granted orphan drug status by the United States Food and Drug Administration (FDA) for the treatment of congenital adrenal hyperplasia (CAH) a disease that affects approximately 20,000-30,000 people in the United States.

16 Jan 2015

Researchers reveal how melanoma becomes resistant to promising new drug combo therapy

In a new study led by UCLA Jonsson Comprehensive Cancer Center member Dr. Roger Lo, researchers have uncovered how melanoma becomes resistant to a promising new drug combo therapy utilizing BRAF+MEK inhibitors in patients after an initial period of tumor shrinkage.

16 Jan 2015

Researchers uncover new gene tied to incurable eye disorder

An exhaustive hereditary analysis of a large Louisiana family with vision issues has uncovered a new gene tied to an incurable eye disorder called retinitis pigmentosa, according to an examination led by scientists at The University of Texas Health Science Center at Houston.

16 Jan 2015

New study demonstrates that vitamin D can protect people against colorectal cancer

A new study by Dana-Farber Cancer Institute investigators demonstrates that vitamin D can protect some people with colorectal cancer by perking up the immune system's vigilance against tumor cells.

16 Jan 2015

GenSpera reports encouraging results from mipsagargin Phase II study for HCC treatment

GenSpera Inc. today announced the encouraging results of a Phase II study of mipsagargin (G-202), an investigational agent for the treatment of hepatocellular carcinoma (HCC).

16 Jan 2015

New research helps explain why pancreatic cancer is so lethal

New research from the University of Michigan Comprehensive Cancer Center helps explain why pancreatic cancer is so lethal, with fewer than a third of patients surviving even early stage disease.

16 Jan 2015

New colloidal gold test strip demonstrates great potential for early detection of heart attack

NYU Polytechnic School of Engineering professors have been collaborating with researchers from Peking University on a new test strip that is demonstrating great potential for the early detection of certain heart attacks.

16 Jan 2015

Endocrine Society issues guideline on prescribing drugs to manage obesity, promote weight loss

The Endocrine Society today issued a Clinical Practice Guideline (CPG) on strategies for prescribing drugs to manage obesity and promote weight loss.

16 Jan 2015

Findings may lead to novel therapeutic approaches to prevent fibrosis in Crohn's disease patients

A natural protein made by immune cells may limit fibrosis and scarring in colitis, according to research published in the inaugural issue of Cellular and Molecular Gastroenterology and Hepatology, the new basic science journal of the American Gastroenterological Association.

16 Jan 2015

CNIO researchers identify new mechanism that influences differentiation of keratinocytes

The formation of human skin involves a cascade of biochemical signals, which are not well understood. However, they are very important since their failure may cause diseases, such as Atopic Dermatitis and skin cancers, which affect more than 25% of the human population.

16 Jan 2015

First medical device approved for treatment of obesity

The United States Food and Drug Administration approved EnteroMedic's VBLOC vagal blocking therapy, delivered via the Maestro System, which is the first medical device approved for obesity treatment that targets the nerve pathway between the brain and the stomach.

15 Jan 2015

Signostics gets FDA 510k clearance for handheld bladder scanner

Medical device company, Signostics, announced today it has clearance from the U.S. Food and Drug Administration to launch the SignosRT Bladder, the company’s new hand-held bladder scanner.

15 Jan 2015

MRIGlobal awarded $54 million NIH contract to provide support for drug development

MRIGlobal today announced that it has been awarded a $54 million, 10-year program from the National Institute of Neurological Disorders and Stroke to provide support for the development and manufacturing of drug candidates for ultimate use in human clinical trials.

15 Jan 2015

PTEN protein helps prevent autoimmune diseases

St. Jude Children's Research Hospital scientists have discovered that a protein widely known for suppressing tumor formation also helps prevent autoimmune diseases and other problems by putting the brakes on the immune response.

15 Jan 2015

Therapy Box releases app that allows people with limited vocal ability to use own voices

The UK-based Therapy Box has released the first app that allows people who have limited vocal ability or are losing their voices due to ALS and other disabling conditions to replace generic text-to-speech synthesis with a synthesizer based on their own voice. The app breaks new ground via the integration of ModelTalker, a program developed by Tim Bunnell, PhD and colleagues at the Nemours Speech Research Laboratory in Wilmington, DE.

15 Jan 2015

Philips, Indica Labs partner to offer advanced image analysis algorithms for cancer research

Royal Philips today announced that it will further support oncology researchers' efforts to analyze pathology samples by offering advanced image analysis algorithms from Indica Labs, Inc. as part of its Digital Pathology Solutions offerings.

15 Jan 2015

Endocrinology Network offers up-to-date coverage of SGLT2 inhibitors

UBM Medica US announces that Endocrinology Network, a leading online community for endocrinologists and other clinicians who treat patients with T2DM offers comprehensive and up-to-date coverage of the sodium glucose cotransporter 2 (SGLT2) inhibitors.

15 Jan 2015

Medical Condition News

Abnormal attachment of sugar to BACE1 enzyme leads to formation of Aβ plaques in the brain

Researchers gain new insight into fragile X syndrome

MD Anderson honored with top science and technology award in China

FDA grants orphan drug status to NBI-77860 for treatment of congenital adrenal hyperplasia

Researchers reveal how melanoma becomes resistant to promising new drug combo therapy

Researchers uncover new gene tied to incurable eye disorder

New study demonstrates that vitamin D can protect people against colorectal cancer

GenSpera reports encouraging results from mipsagargin Phase II study for HCC treatment

New research helps explain why pancreatic cancer is so lethal

New colloidal gold test strip demonstrates great potential for early detection of heart attack

Endocrine Society issues guideline on prescribing drugs to manage obesity, promote weight loss

Findings may lead to novel therapeutic approaches to prevent fibrosis in Crohn's disease patients

CNIO researchers identify new mechanism that influences differentiation of keratinocytes

First medical device approved for treatment of obesity

Signostics gets FDA 510k clearance for handheld bladder scanner

MRIGlobal awarded $54 million NIH contract to provide support for drug development

PTEN protein helps prevent autoimmune diseases

Therapy Box releases app that allows people with limited vocal ability to use own voices

Philips, Indica Labs partner to offer advanced image analysis algorithms for cancer research

Endocrinology Network offers up-to-date coverage of SGLT2 inhibitors

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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