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IMBRUVICA demonstrates anti-tumor activity against multiple myeloma in Phase II study

New IMBRUVICA (ibrutinib) Phase II data announced here today by Pharmacyclics, Inc) during the 56th American Society of Hematology Annual Meeting suggests that IMBRUVICA demonstrates anti-tumor activity both as a single-agent and as combination therapy in heavily pre-treated patients with relapsed or relapsed/refractory multiple myeloma (MM).

7 Dec 2014

Orexo announces positive results from ISTART/006 study

Orexo US, Inc. announced results from the ISTART/006 study, being presented today at the 25th Annual Meeting and Symposium of the American Academy of Addiction Psychiatry in Aventura, Florida, USA.

7 Dec 2014

Novel treatments show safe responses in patients with relapsed, treatment-resistant blood cancers

Novel treatments that harness the body's own immune cells to attack cancer cells demonstrate safe and durable responses in patients with relapsed and treatment-resistant blood cancers, according to data presented today at the 56th American Society of Hematology Annual Meeting and Exposition.

7 Dec 2014

Scientists suspect role of mini-chromosomes in cancers, diseases caused by gene mutations

Cancers are due to genetic aberrations in certain cells that gain the ability to divide indefinitely. This proliferation of sick cells generates tumors, which gradually invade healthy tissue. Therefore, current therapies essentially seek to destroy cancer cells to stop their proliferation. Through high-throughput genetic sequencing of glioblastoma cells, one of the most deadly brain tumors, a team of geneticists from the University of Geneva's (UNIGE) Faculty of Medicine discovered that some of these mutations are caused by supplemental extrachromosomal DNA fragments, called double minutes, which enable cancer cells to better adapt to their environment and therefore better resist to treatments meant to destroy them.

6 Dec 2014

Comb-shaped polymers efficiently protect proteins in vivo

An enzyme that usually triggers strong allergic reactions now circulates in the veins of a group of mice without alerting the immune system. As INRS Énergie Matériaux Télécommunications Research Centre Professor Marc A. Gauthier explains in an article published in the journal Nature Communications, a polymer was used to camouflage the enzyme before it was injected into the rodents. This was achieved by coating the enzyme to avoid an immune response in a manner that does not compromise its activity.

6 Dec 2014

Study suggests Golgi as potential drug target for Alzheimer's treatment

Alzheimer's disease (AD) progresses inside the brain in a rising storm of cellular chaos as deposits of the toxic protein, amyloid-beta (Aβ), overwhelm neurons. An apparent side effect of accumulating Aβ in neurons is the fragmentation of the Golgi apparatus, the part of the cell involved in packaging and sorting protein cargo including the precursor of Aβ. But is the destruction the Golgi a kind of collateral damage from the Aβ storm or is the loss of Golgi function itself part of the driving force behind Alzheimer's? This was the question for Yanzhuang Wang, Gunjan Joshi, and colleagues at the University of Michigan, Ann Arbor, as they set out to uncover the mechanism damaging the Golgi, using a transgenic mouse and tissue culture models of AD to look at what was going on.

6 Dec 2014

Genetics may play major role in Lou Gehrig's disease, study reveals

Genetics may play a larger role in causing Lou Gehrig's disease than previously believed, potentially accounting for more than one-third of all cases, according to one of the most comprehensive genetic studies to date of patients who suffer from the condition also known as amyotrophic lateral sclerosis, or ALS.

6 Dec 2014

Researchers identify important neural mechanism responsible for certain chronic pain disorders

Pain typically has a clear cause-but not always. When a person touches something hot or bumps into a sharp object, it's no surprise that it hurts. But for people with certain chronic pain disorders, including fibromyalgia and phantom limb pain, a gentle caress can result in agony.

6 Dec 2014

University of Utah professor develops MORE intervention program for chronic pain patients

How can people who are dependent on prescription opioids reduce their cravings? Learn to enjoy other aspects of their lives.

6 Dec 2014

Jakafi receives expanded approval from FDA for use in treatment of polycythemia vera

Diplomat Pharmacy, Inc., the nation's largest independent specialty pharmacy, announced that the U.S. Food and Drug Administration has approved an expanded indication of Jakafi (ruxolitinib).

5 Dec 2014

University of Miami researcher reveals association between 'salience processing' and brain disorders

How does the brain determine what matters? According to a new scientific article, a brain structure called the insula is essential for selecting things out of the environment that are "salient" for an individual, and dysfunction of this system is linked to brain disorders such as autism, psychosis and dementia.

5 Dec 2014

Ashish Nimgaonkar wins AGA-Boston Scientific Career Development Technology & Innovation Award

The American Gastroenterological Association Research Foundation is pleased to announce that Ashish Nimgaonkar, MBBS, MTech, MS, from John Hopkins University, has received the inaugural AGA-Boston Scientific Career Development Technology & Innovation Award. This award is graciously supported by a grant from Boston Scientific, a leading innovator of medical solutions.

5 Dec 2014

Janssen, American Diabetes Association team up to launch national educational campaign on diabetes

Janssen Pharmaceuticals, Inc. today announced a collaboration with the American Diabetes Association to launch Teaming Up to Take On Diabetes, a national educational campaign intended to help the nearly 30 million Americans living with diabetes better understand and manage the disease.

5 Dec 2014

Pharmacyclics launches informCLL registry to explore natural history of CLL patients

Pharmacyclics, Inc. today announced the launch of informCLL, a large, observational, prospective registry that will explore the natural history of chronic lymphocytic leukemia (CLL), examine how IMBRUVICA (ibrutinib) and other approved targeted therapies are being used to treat patients with CLL, and provide a comparison to treatments using conventional chemoimmunotherapy (CIT).

5 Dec 2014

Computer games benefit stroke survivors, improve arm movements

Stroke survivors can have "significant" improvement in arm movements after using the Nintendo Wii as physiotherapy according to researchers.

5 Dec 2014

Risk of developing obesity, type 2 diabetes and cardiovascular disease starts in pregnancy

The risk of developing type 2 diabetes, obesity, and cardiovascular disease is affected by exposures in the uterus. Researchers at Lund University in Sweden are now calling for updated guidelines in light of research evidence from the past decades.

5 Dec 2014

$New study examines efficacy of brace application for treatment of spinal compression fractures$

New study examines efficacy of brace application for treatment of spinal compression fractures

Compression fractures in the spine due to osteoporosis, a common condition causing progressive bone loss and increased fracture risk, are especially common in older women. A new study appearing in the December 3rd issue of the Journal of Bone & Joint Surgery found that patients who wore a brace as treatment for a spinal compression fracture had comparable outcomes in terms of pain, function and healing when compared to patients who did not wear a brace.

5 Dec 2014

Researchers discover essential role of intestinal immune system in controlling energy metabolism

A group of UCL researchers (Louvain Drug Research Institute) identified an unsuspected mechanism impacting the development of obesity and diabetes type 2 after following a diet with a high dose of fat nutrition.

5 Dec 2014

Researchers develop new tool for global leaders to better control cancer

With the number of global cancer cases expected to increase by more than 50 percent by 2030, researchers around the globe have collaborated to create a new tool for global leaders to determine what actions they must take to better control cancer.

5 Dec 2014

Breakthrough research could lead to prosthetic retinas for people suffering from retinal damage

Scientists have developed a new light-sensitive film that could one day form the basis of a prosthetic retina to help people suffering from retinal damage or degeneration. Hebrew University of Jerusalem researchers collaborated with colleagues from Tel Aviv University and Newcastle University in the research, which was published in the journal Nano Letters.

5 Dec 2014

Medical Condition News

IMBRUVICA demonstrates anti-tumor activity against multiple myeloma in Phase II study

Orexo announces positive results from ISTART/006 study

Novel treatments show safe responses in patients with relapsed, treatment-resistant blood cancers

Scientists suspect role of mini-chromosomes in cancers, diseases caused by gene mutations

Comb-shaped polymers efficiently protect proteins in vivo

Study suggests Golgi as potential drug target for Alzheimer's treatment

Genetics may play major role in Lou Gehrig's disease, study reveals

Researchers identify important neural mechanism responsible for certain chronic pain disorders

University of Utah professor develops MORE intervention program for chronic pain patients

Jakafi receives expanded approval from FDA for use in treatment of polycythemia vera

University of Miami researcher reveals association between 'salience processing' and brain disorders

Ashish Nimgaonkar wins AGA-Boston Scientific Career Development Technology & Innovation Award

Janssen, American Diabetes Association team up to launch national educational campaign on diabetes

Pharmacyclics launches informCLL registry to explore natural history of CLL patients

Computer games benefit stroke survivors, improve arm movements

Risk of developing obesity, type 2 diabetes and cardiovascular disease starts in pregnancy

New study examines efficacy of brace application for treatment of spinal compression fractures

Researchers discover essential role of intestinal immune system in controlling energy metabolism

Researchers develop new tool for global leaders to better control cancer

Breakthrough research could lead to prosthetic retinas for people suffering from retinal damage

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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