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New RNA therapy reverses symptoms of progeria in mouse models

Children who develop deep wrinkles, stunted growth, and rapidly aging bones and blood vessels as early as 1 to 2 years of age may be suffering from Hutchinson-Gilford Progeria Syndrome (HGPS), a rare and incurable genetic disorder that affects approximately one in eight million people.

29 Jul 2025

Warfarin use not linked to higher brain bleed risk after falls in older adults

There are about 70 million baby boomers in the United States, many now over age 65. As people age, rates of cardiovascular and cerebrovascular diseases rise, leading to more use of blood thinners such as warfarin.

29 Jul 2025

NR2F1 drives fibrotic cataract formation through activation of STAT3

Cataracts remain one of the most prevalent and debilitating eye conditions, often requiring surgical intervention to restore sight. Yet even after surgery, many patients develop anterior subcapsular cataracts (ASC), characterized by fibrotic tissue growth beneath the lens capsule.

29 Jul 2025

Pyruvate identified as a promising oral treatment for ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory disease marked by intestinal pain, bleeding, and impaired gut barrier function.

29 Jul 2025

Senescent macrophages emerge as key drivers of tumor progression

Macrophages are versatile immune cells, tasked with cleaning up pathogens and maintaining tissue health.

29 Jul 2025

NKAPL identified as a tumor suppressor and therapeutic target in NSCLC

Non-small cell lung cancer (NSCLC) accounts for over 80% of lung cancer cases and is often diagnosed at advanced stages, limiting treatment options.

29 Jul 2025

WHO urges urgent action to eliminate hepatitis and reduce liver cancer deaths

As we mark World Hepatitis Day, WHO calls on governments and partners to urgently accelerate efforts to eliminate viral hepatitis as a public health threat and reduce liver cancer deaths.

29 Jul 2025

Microcone-enhanced microfluidic device captures circulating tumor cells efficiently

Circulating tumor cells (CTCs) refer to cancer cells that have broken off from a primary tumor. These tumor cells can travel through the blood in the circulatory system and lodge themselves in other organs to cause secondary tumors.

29 Jul 2025

New blood markers predict kidney disease and mortality in diabetes

Kidney complications in diabetes often progress silently, putting patients at risk of life-threatening outcomes long before any symptoms appear. Identifying individuals with diabetes who are at risk of rapid kidney function decline or early death has challenged doctors for decades, with traditional markers like serum creatinine and urinary albumin falling short of accurately predicting these risks.

29 Jul 2025

Plant-based agent inhibits key protein to reduce bronchial thickening

A plant-based agent inhibits a protein that, among other things, is responsible for the dreaded thickening of the bronchial wall.

29 Jul 2025

Immunotherapy shows promise in changing leukemia’s cellular environment

Scientists studying a hard-to-treat form of blood cancer called acute myeloid leukemia (AML) have found that a type of treatment - immunotherapy - may help change the environment where cancer cells live, possibly helping the immune system respond more effectively.

29 Jul 2025

Groundbreaking Living Brain Project challenges decades of assumptions in neuroscience

In a revealing Genomic Press Interview published today in Genomic Psychiatry, Dr. Alexander W. Charney describes how treating patients with schizophrenia transformed his scientific pursuits from abstract questions to an urgent mission, ultimately leading to discoveries that challenge fundamental assumptions in neuroscience research.

29 Jul 2025

Mexican neuroscientist's journey from exile to schizophrenia research breakthroughs

In a revealing Genomic Press Interview published today in Brain Medicine, Dr. Camilo de la Fuente-Sandoval shares how personal history and scientific passion converged to create groundbreaking advances in schizophrenia treatment prediction.

29 Jul 2025

Gut mycobiota could help predict disability in multiple sclerosis

Gut fungal communities may impact multiple sclerosis severity, offering new insights into MS pathogenesis and potential microbiome-based treatment strategies.

29 Jul 2025

New research provides the first clinically relevant overview of childhood brain tumors

Childhood brain tumor survival depends on the type of tumor. Comparing survival rates across countries is difficult, because brain tumors aren't recorded in the same way everywhere in Europe. A new study led by the Princess Máxima Center is helping to change that. For the first time, the research provides a clear and clinically relevant overview of survival outcomes for children with brain tumors.

29 Jul 2025

Greener cities reduce dementia risks linked to air pollution

Boosting greenery may protect against air pollution's impact on dementia, revealing a potential strategy to reduce Alzheimer's disease burden globally.

29 Jul 2025

Scientists uncover new brain mechanism driving PTSD and potential counter-drug

Did you know that patients with post traumatic stress disorder (PTSD) often struggle to forget traumatic memories, even long after the danger has passed? This failure to extinguish fear memories has long puzzled scientists and posed a major hurdle for treatment, especially since current medications targeting serotonin receptors offer limited relief for only a subset of patients.

29 Jul 2025

Researchers map key mechanism for bladder function

Urinary incontinence is a devastating condition affecting over 33 million Americans, according to the National Association for Continence, leading to significant adverse impacts on patients' mental health and quality of life. Disorders of urination are also a key feature of all neurological disorders.

29 Jul 2025

New research links age-related gene changes to symptom decline

UCSF researchers have found that certain antiviral genes become less active over time in lupus, revealing why some patients see their symptoms fade as they age.

29 Jul 2025

What’s better for your gut: lean beef or chicken? Science weighs in

A crossover trial in healthy young adults found that both lean chicken and beef diets reduced gut microbial richness, but only chicken caused significant diversity loss. The study highlights that lean local beef may have a milder impact on the gut microbiome than chicken.

29 Jul 2025