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Study finds common risk factors linked with painkiller addiction

A new Geisinger study begins to unlock the puzzle of painkiller (opioid) addiction - why some people are more likely to become addicted than others. Geisinger investigators have found that patients with four common risk factors have a significantly higher risk of addiction. In addition, a history of severe drug dependence and drug abuse compounds the risk.

30 Aug 2010

Cigarettes as mood enhancers increase risk of depression

While some teenagers may puff on cigarettes to 'self-medicate' against the blues, scientists at the University of Toronto and the University of Montreal have found that smoking may actually increase depressive symptoms in some adolescents. Published in the journal Addictive Behaviors, the findings are part of the long-term Nicotine Dependence in Teens (NDIT) study based at the University of Montreal Hospital Research Centre.

27 Aug 2010

Merck's initiation of IMO-2055 Phase 1b clinical trial in SCCHN triggers €3.0M milestone payment to Idera

Idera Pharmaceuticals, Inc., today announced that it has achieved a milestone under its worldwide licensing and collaboration agreement with Merck KGaA, Darmstadt, Germany. The milestone was achieved upon Merck KGaA's initiation of a Phase 1b clinical trial of IMO-2055 (EMD 1201081), an agonist of Toll-like Receptor 9 (TLR9), in combination with cisplatin, fluorouracil and cetuximab (Erbitux®) in first-line treatment of patients with squamous cell carcinoma of the head and neck (SCCHN).

27 Aug 2010

Traumatic brain injury causes $6.8 billion worth of economic trauma in Texas

Each year in Texas, traumatic brain injury (TBI) causes an estimated $6.8 billion worth of economic trauma in terms of deaths, emergency room visits, hospitalizations and disability, according to a study commissioned by the CORE Health Foundation. To put that dollar amount in perspective, it equals Coca-Cola's corporate profit for fiscal 2009.

27 Aug 2010

Transcatheter heart valve replacement recipient celebrates 102nd birthday

When Doris Snyder celebrated her 102nd birthday on August 10, she was that much closer to the expected birth of her first great-granddaughter who's due to arrive early September. She is very excited about the milestone, which might not have been possible were it not for a cutting-edge, experimental procedure that replaced one of Doris' heart valves weeks earlier when she was 101. The valve had been rendered useless by aortic valve stenosis—hardening from calcium deposits that restrict the flow of blood from the heart.

27 Aug 2010

FDA approves Novartis' Tekamlo for treatment of high blood pressure

The US Food and Drug Administration (FDA) approved Tekamlo™ (aliskiren and amlodipine) tablets, a single-pill for the treatment of high blood pressure combining the only approved direct renin inhibitor, Tekturna® (aliskiren), with the widely used calcium channel blocker amlodipine. Tekamlo is approved as initial therapy for patients who are likely to need multiple drugs to achieve their blood pressure goals, and as replacement therapy for patients whose blood pressure is not adequately controlled with either aliskiren or amlodipine alone.

27 Aug 2010

KemPharm broadens protection for LAT prodrug technology platform for ADHD with second patent

KemPharm, Inc. announced today that it has received a Notice of Issuance from the United States Patent and Trademark Office (USPTO) for its patent application entitled "Non-Standard Amino Acid Conjugates of Amphetamine and Processes for Making and Using the Same", U.S. Patent No. 7,776,917 B2. This patent, combined with KemPharm's recently issued U.S. Patent No. 7,772,222, provides broad protection of the Company's Ligand Activated Therapy (LAT) prodrug technology platform and its application to the treatment of Attention Deficit – Hyperactivity Disorder.

27 Aug 2010

Most home care clients rely on informal care from spouse or child

One in six people providing informal care to seniors experiences distress, according to a new study released today by the Canadian Institute for Health Information (CIHI), and those caring for seniors with moderate to severe cognitive impairment, such as those with Alzheimer's or other dementia, are most at risk.

27 Aug 2010

Research: Impact of seafood components on human health

Seafood has an enormous potential to promote health. At the same time the opportunities for innovation and value creation are huge. Knowledge and documentation are the keys to success.

27 Aug 2010

APF offers actionable solutions to improve access to pain care

The American Pain Foundation (APF), the nation's largest consumer advocacy organization for people in pain, released today a position statement imploring the medical community, regulators and concerned stakeholders to reaffirm their ethical commitment to the 76.5 million Americans—or one in four people—who struggle with pain, work collaboratively to improve access to pain care and dismantle the barriers preventing timely, appropriate and effective pain care for millions.

27 Aug 2010

Mixed pathologies in brains of elderly account for memory loss and confusion

Most recent studies show that elderly people over the age of 80 often have mixed pathologies in their brains that account for their memory loss and confusion. Very few senior citizens have "pure Alzheimer disease"; therefore, this terminology should be used with caution. It now appears that vascular problems such as high blood pressure and diabetes can shrink the parts of the brain that control memory and can significantly affect at what age elderly people become demented.

27 Aug 2010

World's tallest man undergoes Gamma Knife surgery

Much of Sultan Kosen's eight feet, two-inch stature rose up in an 17-year period starting at age 10, when the benign tumor in his brain's pituitary gland highjacked the organ, causing it to secrete massive amounts of growth hormone, making Mr. Kosen's body grow fast and grow without ceasing. He will need to wait several months to find out if his Gamma Knife® surgery last Thursday at the University of Virginia (UVA, Charlottesville, Va.) has inactivated the tumor and he has reached his final height, but his physicians are optimistic.

27 Aug 2010

Expansion of rapid response systems throughout the Veterans Affairs network can reduce morbidity

Implementing a rapid response team to aid in managing "potentially unstable" patients has led to a sharp reduction in the rate of cardiac arrests at a U.S. Veterans Affairs (VA) hospital, reports a study in the September issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

27 Aug 2010

Athera Biotechnologies, Electra-Box Diagnostica sign distribution agreement for 'CVDefine' kit

Athera Biotechnologies and Electra-Box Diagnostica, announced today that they have signed an agreement for distribution of "CVDefine" kit. CVDefine measures a new biomarker in blood, a specific anti-body, that has been linked to increased risk for cardiovascular disease. Athera Biotechnologies is part of the Karolinska Development portfolio.

27 Aug 2010

'Molecular Diagnostics Europe' conference debuts at BIOTECHNICA 2010

BIOTECHNICA, Europe's Leading Exhibition for Biotechnology and Life Sciences, is broadening its portfolio to include a new conference and special display on molecular diagnostics. Produced by the Cambridge Healthtech Institute, a leading organizer of biomedical conferences in the United States, the "Molecular Diagnostics Europe" (MDxEU) conference is making its debut this year. The main focus will be on new methods for molecular diagnostics, particularly with regard to cancer and infectious diseases.

27 Aug 2010

'Neural inertia' may explain brain's resistance to changes in consciousness

Despite the fact that an estimated 25 million patients per year in the U.S. undergo surgeries using general anesthesia, scientists have only been able to hypothesize exactly how anesthetics interact with the central nervous system. They previously thought that the processes of "going under" and waking up from anesthesia affected the brain in the same way.

27 Aug 2010

Second-hand smoke triggers complex inflammatory response

Second-hand smoke is associated with a number of diseases and conditions, including cancer, heart disease, and emphysema. It is an irritant to lung tissue and blood vessels, but the processes through which the body reacts to second-hand smoke comprise a mystery scientists are only beginning to unravel. Researchers at the University of Colorado-Denver are currently studying how second-hand smoke affects the lungs of rats, and so far it appears that second-hand smoke triggers a complex inflammatory response.

27 Aug 2010

Shire receives European marketing approval for VPRIV therapy to treat type 1 Gaucher disease

Shire, the global specialty biopharmaceutical company, announced today that the European Commission has granted marketing authorisation for VPRIV(R) (velaglucerase alfa), a human cell line derived enzyme replacement therapy (ERT) for the long-term treatment of type 1 Gaucher disease.

27 Aug 2010

Luminex launches FDA-cleared xTAG Cystic Fibrosis 60 Kit v2 diagnostic test

Luminex Corporation, the worldwide leader in multiplexed solutions, today announced the full commercial launch of its xTAG Cystic Fibrosis 60 Kit v2, a new diagnostic test that can simultaneously screen a single blood sample for up to 60 cystic fibrosis-causing genetic mutations in a matter of hours.

From Thermo Fisher Scientific Inc. 27 Aug 2010

MCNA announces $2 million to launch HEAL program for childhood asthma management

The mold that spread like a rash across post-Katrina New Orleans did more than destroy homes - it made children with asthma sick. On the fifth anniversary of Hurricane Katrina, experts point to increased sensitivities to environmental asthma triggers as a risk for more severe asthma symptoms and attacks in hundreds of New Orleans children.

27 Aug 2010