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RCSI review highlights development in drug discovery field

A research review carried out by the Royal College of Surgeons in Ireland (RCSI) and published in 'Nature Reviews and Drug Discovery' (October 2010) has highlighted the lessons, opportunities and recent developments in the area of drug development for cardiovascular disease, auto-immune disorders and multiple sclerosis.

25 Nov 2010

Tension-dependent stabilization helps chromosome separation machinery

Scientists have discovered an amazingly simple way that cells stabilize their machinery for forcing apart chromosomes. Their findings are reported Nov. 25 in Nature.

25 Nov 2010

Response to PLX4032 drug short lived in BRAF-mutated metastatic melanoma patients

Researchers with UCLA's Jonsson Comprehensive Cancer Center have found that melanoma patients whose cancers are caused by mutation of the BRAF gene become resistant to a promising targeted treatment through another genetic mutation or the overexpression of a cell surface protein, both driving survival of the cancer and accounting for relapse.

25 Nov 2010

New NIVI tissue-imaging technique can accurately detect cancer cells

The long, anxious wait for biopsy results could soon be over, thanks to a tissue-imaging technique developed at the University of Illinois.

25 Nov 2010

Researchers find IGF1 topical gel can treat sudden sensorineural hearing loss

A new treatment has been developed for sudden sensorineural hearing loss (SSHL), a condition that causes deafness in 40,000 Americans each year, usually in early middle-age.

24 Nov 2010

Chronic high fat cholesterol diet may lead to Alzheimer's disease

Research from the Laboratory of Psychiatry and Experimental Alzheimers Research at the Medical University Innsbruck (Austria) demonstrated that chronic high fat cholesterol diet in rats exhibited pathologies similar to Alzheimer's disease. The results were published in Molecular Cellular Neuroscience with lead author Dr. Christian Humpel. The study was co-authored by PhD students, Celine Ullrich and Michael Pirchl, from the same Laboratory.

24 Nov 2010

Discovery may lead to new generation of drugs to minimize heart attack risk

An international team led by researchers from the Universities of Leicester and Cambridge has announced a breakthrough in identifying people at risk of developing potentially fatal blood clots that can lead to heart attack.

24 Nov 2010

Diabetes drug may counteract against Alzheimer's disease: Research

Metformin, a drug used in type 2-diabetes might have the potential to also act against Alzheimer's disease. This has been shown in a study from scientists of the German Center for Neurodegenerative Diseases (DZNE), the University of Dundee and the Max-Planck-Institute for Molecular Genetics.

24 Nov 2010

Advaxis initiates ADXS11-001 clinical trial for cervix cancer

Advaxis, Inc., the live, attenuated Listeria monocytogenes (Listeria) immunotherapy company, has begun dosing patients in its 110 patient clinical trial of ADXS11-001 for the treatment of cervix cancer in women for whom cytotoxic treatment has failed.

24 Nov 2010

USFDA grants Sun Pharma tentative marketing approval for generic Cymbalta

Sun Pharmaceutical Industries Ltd. announced that USFDA has granted its subsidiary a tentative approval for an Abbreviated New Drug Application (ANDA) to market a generic version of Cymbalta®, duloxetine hydrochloride delayed-release capsules.

24 Nov 2010

Cancers detected late leading to unnecessary deaths: Report

A new report released Wednesday by the U.S. Centers for Disease Control and Prevention (CDC) says that in spite of the widely available screening tests many cancers are not diagnosed until the disease is well-advanced and, therefore, less treatable and more fatal. The report says that half of colorectal cancers and cervical cancers and one-third of breast cancers in the United States are detected at a late stage.

24 Nov 2010

Association for Psychological Science journal presents new research

Adults with insecure attachment styles may have difficulties regulating emotions and this may put them at an increased risk for mental health problems. Volunteers underwent fMRI scans while performing an emotion-word Stroop task. Participants with tendencies towards insecure attachment demonstrated more activity in the right orbitofrontal cortex and superior frontal gyrus for unpleasant words, suggesting that insecure attachment may involve intense reactions to negative words.

24 Nov 2010

Los Angeles philanthropist foundation model to commercialize research at Ben-Gurion University

A Los Angeles philanthropist has created an innovative foundation model that will provide up to $1.2 million to help fund and commercialize research at Ben-Gurion University of the Negev in Beer-Sheva, Israel.

24 Nov 2010

On Thanksgiving Day never mind conflict with the in-laws; it's cake vs. cranberry, pie vs. wine

If you're lucky, it will all be kisses and hugs around the Thanksgiving dinner table, with friends and family near and dear gathered about, and puppies gathered around your feet waiting for table scraps.

24 Nov 2010

New Colorectal Cancer Screening program in Quebec

On behalf of the Colorectal Cancer Association of Canada, I would like to thank Minister Bolduc and the Ministère de la Santé et des Services Sociaux for taking the first steps to implement the Colorectal Cancer Screening program in Quebec.

24 Nov 2010

Eating Disorder Hope partners with MyPyramid to help eating disorder sufferers

Eating Disorder Hope, a respected independent resource for sufferers of anorexia, bulimia and overeating disorders, has partnered with MyPyramid to help eating disorder sufferers find nutritional and healthy lifestyle support.

24 Nov 2010

Study finds solution for debate about mutation testing to prevent children with cystic fibrosis

Testing for genetic mutations beyond those medically recommended is unlikely to prevent the birth of children with classic cystic fibrosis and may detect mutations causing only mild disease, according to a study published online in Genetics in Medicine, the official publication of the American College of Medical Genetics (ACMG).

From Quest Diagnostics 24 Nov 2010

Testing less frequently not a good way to economize for people living with diabetes

The American economy is struggling— and people living with diabetes are feeling the brunt of the rising prices of medical supplies and doctor visit co-pays. In a recent poll by dLife.com, more than 400 people living with diabetes revealed they struggle when it comes to paying for diabetic supplies.

24 Nov 2010

Provectus reports progress in PV-10 program for metastatic melanoma

Provectus Pharmaceuticals, Inc., a development-stage oncology and dermatology biopharmaceutical company, reports continued progress in its compassionate use program for PV-10. The program currently has enrolled more than 40 patients, ten of whom are expanded access patients from the company's Phase 2 trial of PV-10 for metastatic melanoma, as well as more than 30 new patients.

24 Nov 2010

Hepcidin hormone may be potential therapeutic tool for anemic blood disorders

A hormone made by the body may be a potential therapeutic tool for the treatment of two anemic blood disorders beta-thalassemia and hemochromatosis. The new research was led by scientists at Weill Cornell Medical College and published in the Journal of Clinical Investigation and the journal Blood.

24 Nov 2010