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Researchers join forces to 'map' specific variations in more than 25 key cardiac disease genes

One in 100 people have genetic variations that can cause potentially life-threatening heart conditions, including high cholesterol (lipid disorders), heart muscle disease (cardiomyopathies), and abnormal heart rhythms (arrhythmias).

13 Sep 2022

Immunotherapy before surgery improves outcomes in many patients with stage II–IV cutaneous squamous cell carcinoma

In an international, multicenter Phase II clinical trial led by The University of Texas MD Anderson Cancer Center, 63.3% of patients with stage II–IV cutaneous squamous cell carcinoma (CSCC) saw their tumors nearly or completely disappear when treated with immunotherapy before surgery.

13 Sep 2022

Study investigates the prevalence of adrenal tumors in an unselected screening population

A cross-sectional study of more than 25,000 adults has found that with increased screening, the prevalence of adrenal tumors in an unselected community population was 1.4%. The prevalence increased with age, from 0.2% in adults aged 18 to 25 up to 3.2% in adults older than 65 years of age. However, approximately 70% of identified tumors were nonfunctioning, meaning they did not make extra hormones, regardless of the participant's age. The findings are published in Annals of Internal Medicine.

13 Sep 2022

$Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer$

Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that the targeted therapy fruquintinib significantly improved overall survival (OS) and progression-free survival (PFS) in patients with refractory metastatic colorectal cancer.

13 Sep 2022

Molecular explanation for the contribution of autophagy to BAT energy metabolism

Obesity is a growing global health problem and its prevalence has tripled since 1975. More than 650 million people are affected by this condition worldwide, and 28% of people in Spain over 18 years of age have this complex pathology. Obesity is linked to conditions such as type II diabetes, cardiovascular disease, osteoarthritis, and certain forms of cancer.

13 Sep 2022

MSK researchers reveal a promising treatment option for bladder cancer patients

Researchers from Memorial Sloan Kettering Cancer Center (MSK) shared a promising treatment option for bladder cancer patients today at The European Society for Medical Oncology (ESMO) Congress 2022.

13 Sep 2022

Study explores work experiences and quality of life for Hispanic survivors

As a cancer nurse in the U.S. Army for more than 29 years, Elizabeth Anderson saw firsthand how chemotherapy, radiation and surgeries impact the body's lymphatic system, putting breast cancer survivors at greater risk for developing lymphedema, a chronic condition of swelling that may occur after surgical removal, chemotherapy treatment, or irradiation of lymph nodes.

13 Sep 2022

HSD3B1 gene holds clues for predicting and treating endometrial cancer

The HSD3B1 gene could hold clues for predicting and treating endometrial cancer, according to a novel finding from the Cleveland Clinic's Lerner Research Institute.

13 Sep 2022

New long-term opioid use associated with a heightened risk of death, study finds

New long term use of opioids to quell pain after lung cancer surgery is linked to a 40% heightened risk of death from any cause within the next 2 years, finds research published online in the journal Regional Anesthesia & Pain Medicine.

13 Sep 2022

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center.

13 Sep 2022

Study investigates BMI, race, and lung cancer diagnosis relationships

Lung cancer is the leading cause of cancer death in the US, making up 25% of cancer deaths. With obesity rates simultaneously rising, researchers have investigated the connections between cancer risk and body mass index (BMI). Unlike most other cancer types, where higher BMI is associated with increased risk of cancer, research has established that paradoxically people with higher BMI have lower rates of lung cancer diagnosis.

13 Sep 2022

Age-related changes in microbiome composition affects brain macrophages

Scientists review the impact of age-related gut microbiome composition on age-associated diseases caused by dysfunctional macrophages within the brain.

13 Sep 2022

Is there a right time for eating?

In a recent study published in the journal Cell Metabolism, researchers assessed how calorie or energy intake (EI) time influences calorie distribution and all energy expenditure (EE) components, which, in turn, impact energy balance and weight loss in healthy obese people.

12 Sep 2022

$Worldwide hip fracture counts likely to double by 2050, study finds$

Worldwide hip fracture counts likely to double by 2050, study finds

Osteoporotic hip fracture, already a dangerous and debilitating problem for older men and women worldwide, is poised to become a far more severe global public-health issue as the population grows older and frailer, according to a new study led by researchers at the University of Hong Kong.

12 Sep 2022

Antibiotics accelerate metastatic bone growth in mice with melanoma by depleting intestinal flora

The use of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive form of skin cancer, accelerated their metastatic bone growth, likely because the drugs depleted the mice's intestinal flora and weakened their immune response, according to a new study by researchers at Emory University in Atlanta.

12 Sep 2022

Blocking FNDC5 prevents cancer-induced cachexia in mice

The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found.

12 Sep 2022

Vaccines that induce mucosal immunity against SARS-CoV-2 are needed

In a recent study posted to the medRxiv* preprint server, researchers in the United Kingdom studied assessed plasma and nasal antibody (Ab) responses induced after a year of coronavirus disease 2019 (COVID-19)-associated hospitalization and the potential boost by subsequent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations in the United Kingdom (UK).

12 Sep 2022

Study reveals recommended levels of long-term blood sugar to avoid diabetes-related damage

The levels of long-term blood sugar, HbA1c, can be used to accurately determine the risk of a person with type 1 diabetes developing eye- and kidney complications.

12 Sep 2022

Oral anticoagulant drug may be safe, effective in preventing blood clots after urologic cancer surgery

The oral anticoagulant drug apixaban may offer a safer, more effective alternative to standard home heparin injections for patients taking extended prophylaxis (EP) to prevent blood-clot-related complications after surgery, reports a study in The Journal of Urology, an Official Journal of the American Urological Association.

12 Sep 2022

Are pesticides affecting childhood growth in low-income countries?

Researchers assess the risk posed by these chemicals to the developing fetus and child.

12 Sep 2022

Medical Condition News

Researchers join forces to 'map' specific variations in more than 25 key cardiac disease genes

Immunotherapy before surgery improves outcomes in many patients with stage II–IV cutaneous squamous cell carcinoma

Study investigates the prevalence of adrenal tumors in an unselected screening population

Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer

Molecular explanation for the contribution of autophagy to BAT energy metabolism

MSK researchers reveal a promising treatment option for bladder cancer patients

Study explores work experiences and quality of life for Hispanic survivors

HSD3B1 gene holds clues for predicting and treating endometrial cancer

New long-term opioid use associated with a heightened risk of death, study finds

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

Study investigates BMI, race, and lung cancer diagnosis relationships

Age-related changes in microbiome composition affects brain macrophages

Is there a right time for eating?

Worldwide hip fracture counts likely to double by 2050, study finds

Antibiotics accelerate metastatic bone growth in mice with melanoma by depleting intestinal flora

Blocking FNDC5 prevents cancer-induced cachexia in mice

Vaccines that induce mucosal immunity against SARS-CoV-2 are needed

Study reveals recommended levels of long-term blood sugar to avoid diabetes-related damage

Oral anticoagulant drug may be safe, effective in preventing blood clots after urologic cancer surgery

Are pesticides affecting childhood growth in low-income countries?

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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