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Scientists develop tool to predict bowel cancer drug resistance

Scientists have developed a tool that can predict how bowel cancer adapts to treatment – helping researchers to design new personalized drugs that will keep patients living well for longer.

20 Jun 2025

Immune changes predict heart risks in cancer patients on checkpoint inhibitors

New research has uncovered immune changes in cancer patients that could help identify which patients are most at risk of dangerous heart complications from cancer drugs, known as immune checkpoint inhibitors.

20 Jun 2025

Targeting ST6Gal-I shows promise in reducing Alzheimer’s disease pathology

A recent study published in Engineering has provided novel insights into the involvement of α2,6-sialylation in Alzheimer's disease (AD), revealing that the ablation of α2,6-sialyltransferase-I (ST6Gal-I), an enzyme responsible for α2,6-sialylation, can downregulate BACE1 expression and suppress the production of amyloid-β42 (Aβ42) plaques, which are hallmarks of AD.

20 Jun 2025

Multiple brain profiles underlie the same symptoms in depression

A novel study aimed at disentangling the neurological underpinnings of depression shows that multiple brain profiles may manifest as the same clinical symptoms, providing evidence to support the presence of both one-to-one and many-to-one heterogeneity in depression.

20 Jun 2025

Exploring the intricate epigenetic regulatory network of lncRNAs in hepatocellular carcinoma

A new review published in Genes & Diseases explores the intricate epigenetic regulatory network of long noncoding RNAs (lncRNAs) in hepatocellular carcinoma (HCC), shedding light on the profound impact of DNA methylation, histone modifications, RNA methylation, and microRNAs on lncRNA transcription.

20 Jun 2025

Placenta and prenatal hormones may drive human brain evolution

The placenta and the hormones it produces may have played a crucial role in the evolution of the human brain, while also leading to the behavioral traits that have made human societies able to thrive and expand, according to a new hypothesis proposed by researchers from the Universities of Cambridge and Oxford.

20 Jun 2025

New technique boosts production of canine stem cells for veterinary use

Mesenchymal stem cells (MSCs), which can be harvested from fat and bone marrow, have immune-modulating and anti-inflammatory effects that are beneficial for both human and veterinary medicine.

20 Jun 2025

AI reveals how H5N1 virus is evolving to evade human immunity

The H5N1 avian influenza virus has infected birds and mammals around the world. As of June 2025, 70 people have been infected, and 1 person has died in the United States.

20 Jun 2025

Monitoring airborne fungal spores predicts flu and COVID-19 surges

Monitoring fungal spores in the outdoor air can predict surges in flu and COVID-19 infections, especially during the fall, according to a new study.

20 Jun 2025

Iodine fortification urged as plant-based milk rise in popularity

Iodine content in plant-based milks is often insufficient, risking deficiencies that affect metabolism and public health, especially in reproductive-age women.

20 Jun 2025

Inflammation and immune dysregulation drive breast cancer in aging women

Age-related and postmenopausal breast cancer progression remains a significant challenge, with growing evidence pointing to the role of pro-inflammatory cytokines and CXC chemokines in tumor development and immune system modulation.

20 Jun 2025

Targeting IGF2BP1 offers a new approach to cancer therapy

The RNA-binding protein IGF2BP1 has emerged as a key regulator of cancer hallmarks, influencing tumor proliferation, metastasis, immune evasion, and resistance to cell death.

20 Jun 2025

Fibroblast Growth Factor 8 drives key processes in embryonic development

The role of Fibroblast Growth Factor 8 (FGF8) in embryonic development and organ formation is gaining increased recognition as scientists uncover its wide-ranging influence.

20 Jun 2025

Circular RNAs emerge as key players in hepatitis B-related liver cancer

Hepatitis B virus-induced hepatocellular carcinoma (HCC) remains a major global health burden, and new therapeutic and diagnostic approaches are urgently needed.

20 Jun 2025

Body composition associated with pelvic floor disorder symptoms in middle-aged women

According to a recent study conducted at the University of Jyväskylä, Finland, body composition is associated with symptoms of pelvic floor disorders in middle-aged women.

19 Jun 2025

Study finds no evidence to suggest mild COVID-19 may cause long-term kidney damage

A new study of over 13 million people in England has found no evidence to suggest mild COVID-19 infection may cause long-term kidney damage.

19 Jun 2025

New Swedish research initiative targets obesity and metabolic diseases

Metabolism and obesity are the focus of a major research initiative by the University of Gothenburg and AstraZeneca, with the support of Knut and Alice Wallenberg Foundation and Region Västra Götaland.

19 Jun 2025

Exploring the dual role of microRNA-223 in hepatic fibrosis

Announcing a new article publication for BIO Integration journal. Liver fibrosis is caused by excessive extracellular matrix accumulation, which in turn is driven by activation of hepatic stellate cells.

19 Jun 2025

Autoantibodies against vinculin linked to childhood kidney disease

Idiopathic nephrotic syndrome (INS) is a serious kidney disease in children with no clear cause. In a recent study, researchers have identified a novel autoantibody targeting vinculin—a protein crucial for kidney cell structure—as a significant factor in INS.

19 Jun 2025

Pandorabactins help pathogenic bacteria compete for iron in the lungs

An interdisciplinary research team led by the Leibniz-HKI in Jena has discovered a new group of bioactive natural compounds in pathogenic bacteria of the genus Pandoraea: pandorabactins.

19 Jun 2025