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Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.

18 Aug 2023

New study untied taste from smell in people with COVID-19

Smell loss became the cardinal symptom of COVID-19 early in the pandemic and has ignited research on how smell and taste function. An international study led by the Global Consortium for Chemosensory Research (GCCR) and the Monell Chemical Senses Center has untied taste from smell in people with COVID-19, demonstrating in a large and diverse group of more than 10,000 people that taste, independent of smell, is also greatly impacted by COVID. The team recently published their findings in Chemical Senses.

18 Aug 2023

Immune cells present in people months before influenza infection, finds study

St. Jude Children's Research Hospital scientists, in collaboration with the Institute of Environmental Science and Research (ESR) Limited, found that immune cells present in people months before influenza (flu) infection could more accurately predict if an individual would develop symptoms than current methods which primarily rely on antibody levels.

18 Aug 2023

New findings could develop effective vaccines or treatments for chikungunya fever

Researchers at Albert Einstein College of Medicine have found that the virus responsible for chikungunya fever can spread directly from cell to cell - perhaps solving the longstanding mystery of how the virus, now emerging as a major health threat, can manage to escape antibodies circulating in the bloodstream.

18 Aug 2023

Study evaluates two multiplex real-time PCR assays for simultaneous detection of MPVX

This study proposes and evaluates two multiplex real-time PCR assays for simultaneous detection and differentiation of monkeypox virus (MPXV) with high specificity and sensitivity.

18 Aug 2023

Platelets quell the inflammation of an aging brain and body: Study finds

Platelets are behind the cognitive benefits of young blood, exercise and the longevity hormone klotho

18 Aug 2023

Male diabetics more likely to have lower limb amputation

New research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg, Germany (2-6 October) shows that among people with type 1 and type 2 diabetes, being divorced is associated with a two-thirds higher risk of lower limb amputation (LLA) (amputations below the knee level) compared with being married, and being male is associated with a 57% higher risk of LLA compared with being female. The study is by Dr Stefan Jansson, Örebro University, Örebro, Sweden, and colleagues.

18 Aug 2023

Understanding how the body regulates circadian rhythms using mathematical models

Researchers are using mathematical models to better understand the effects of disruptions like daylight savings time, working night shifts, jet lag or even late-night phone scrolling on the body's circadian rhythms.

18 Aug 2023

Medications for chronic diseases can impair thermoregulation, especially in hot weather

Medications to treat various chronic diseases may hinder the body’s ability to lose heat and regulate its core temperature to optimal levels.

17 Aug 2023

Study opens the door to new treatments for bone regeneration and osteoporosis

A new study of the PhyloBone project of the University of Turku, Finland, identifies hundreds of non-collagenous proteins in the bone matrix that may play regulatory roles in bone formation and regeneration.

17 Aug 2023

Databases, techniques for variant forecasting and early warning of emerging infectious diseases

The coronavirus disease 2019 (COVID-19) pandemic has dramatically increased the awareness of emerging infectious diseases.

17 Aug 2023

Study reveals the roles of a nucleic acid sensor for COVID-19 in pan-cancer

Toll-like receptor 7 (TLR7), a severe acute respiratory syndrome 2 (SARS-CoV-2) virus's nucleic acid sensor, was discovered to be aberrantly expressed in many types of cancers.

17 Aug 2023

Lorazepam linked to shorter progression-free survival in pancreatic cancer patients

Patients with pancreatic cancer who took the benzodiazepine lorazepam (Ativan), commonly prescribed to treat anxiety during cancer treatment, had a shorter progression-free survival than patients who did not, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR).

17 Aug 2023

Astrocytes play major role in controlling sleep need

New animal research suggests that little-studied brain cells known as astrocytes are major players in controlling sleep need and may someday help humans go without sleep for longer without negative consequences such as mental fatigue and impaired physical health.

17 Aug 2023

Anxious people use different part of brain for social behavior

When choosing their behavior in socially difficult situations, anxious people use a less suitable section of the forebrain than people who are not anxious.

17 Aug 2023

Moffitt receives NCI grant to investigate virus-associated tumors among HIV patients in sub-Saharan Africa

The Center for Immunization and Infection Research in Cancer at Moffitt Cancer Center is expanding its viral infection research in Africa. The cancer center has received a $5.5 million, five-year specialized research center grant (U54CA277834) from the National Cancer Institute to investigate virus-associated tumors that disproportionately impact men and women living with HIV in sub-Saharan Africa.

17 Aug 2023

Obesity impairs brain's ability to learn associations

To control our behavior, the brain must be able to form associations. This involves, for example, associating a neutral external stimulus with a consequence following the stimulus (e.g., the hotplate glows red - you can burn your hand).

17 Aug 2023

Marijuana and hallucinogen use, binge drinking reach highest level among adults 35 to 50

Past-year use of marijuana and hallucinogens by adults 35 to 50 years old continued a long-term upward trajectory to reach all-time highs in 2022, according to the Monitoring the Future (MTF) panel study, an annual survey of substance use behaviors and attitudes of adults 19 to 60 years old.

17 Aug 2023

Immunotherapy combination extends progression-free survival in patients with melanoma

A research team co-led by UCLA investigators has shown that an immunotherapy drug combination can be an effective second-line therapy for patients with an aggressive and deadly type of melanoma that is resistant to the widely used immunotherapy drugs known as PD-1 inhibitors.

17 Aug 2023

Exposure to interpersonal violence throughout childhood or adulthood increases risk of diabetes

According to the results of a new study in the American Journal of Preventive Medicine, published by Elsevier, exposure to interpersonal violence throughout childhood or adulthood increases an individual's chance of developing adult-onset diabetes by more than 20%.

17 Aug 2023

Medical Research News

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

New study untied taste from smell in people with COVID-19

Immune cells present in people months before influenza infection, finds study

New findings could develop effective vaccines or treatments for chikungunya fever

Study evaluates two multiplex real-time PCR assays for simultaneous detection of MPVX

Platelets quell the inflammation of an aging brain and body: Study finds

Male diabetics more likely to have lower limb amputation

Understanding how the body regulates circadian rhythms using mathematical models

Medications for chronic diseases can impair thermoregulation, especially in hot weather

Study opens the door to new treatments for bone regeneration and osteoporosis

Databases, techniques for variant forecasting and early warning of emerging infectious diseases

Study reveals the roles of a nucleic acid sensor for COVID-19 in pan-cancer

Lorazepam linked to shorter progression-free survival in pancreatic cancer patients

Astrocytes play major role in controlling sleep need

Anxious people use different part of brain for social behavior

Moffitt receives NCI grant to investigate virus-associated tumors among HIV patients in sub-Saharan Africa

Obesity impairs brain's ability to learn associations

Marijuana and hallucinogen use, binge drinking reach highest level among adults 35 to 50

Immunotherapy combination extends progression-free survival in patients with melanoma

Exposure to interpersonal violence throughout childhood or adulthood increases risk of diabetes

A new method to measure intracellular water in biological systems

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

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