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Researchers create a physical wiring diagram of the human immune system

In a new study, researchers systematically mapped the surface proteins on human leukocytes to examine interactions between their cell-surface proteomes and develop a physical wiring diagram encapsulating the diversity of surface protein architectures found across all major subsets of leukocytes.

8 Aug 2022

How can we map the human genetic architecture of COVID-19 across all ancestry groups?

In a new study, researchers formed the COVID-19 host genetics initiative to compile a genome-wide association meta-analysis of 60 studies from 25 countries.

8 Aug 2022

Boosting vitamin D in individuals with deficiencies likely to reduce chronic inflammation

Inflammation is an essential part of the body's healing process. But when it persists, it can contribute to a wide range of complex diseases including type 2 diabetes, heart disease, and autoimmune diseases.

8 Aug 2022

Implantable mechanotherapeutic drug delivery platform helps overcome host immune response

Implantable devices that release insulin into the body hold promise as an alternative way to treat diabetes without insulin injections or cannula insertions. However, one obstacle that has prevented their use so far is that the immune system attacks them after implantation, forming a thick layer of scar tissue that blocks insulin release.

8 Aug 2022

Terminally exhausted T cells may remain competent for transcription, researchers say

During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this state was irreversible. However, new insights from University of Pittsburgh and UPMC researchers suggest that even the most fatigued T cells can be revived.

8 Aug 2022

Wrist-wearable devices more cost-effective than electrocardiograms and pulse palpation for atrial fibrillation screening

Screening individuals for atrial fibrillation (AF) using wearable devices is more cost-effective than screening using conventional methods such as 12-lead electrocardiogram (ECG) and pulse palpation, or than no screening at all, researchers from Massachusetts General Hospital (MGH) have found.

8 Aug 2022

Nivolumab approved for combination with fluoropyrimidine- and platinum-based combination chemotherapy

Nivolumab has recently been approved both in combination with fluoropyrimidine- and platinum-based combination chemotherapy and in combination with ipilimumab for the first-line treatment of adults with unresectable advanced, recurrent or metastatic esophageal squamous cell carcinoma with PD-L1 expression of at least one percent. The German Institute for Quality and Efficiency in Health Care (IQWiG) now examined in two early benefit assessments whether these two combinations have an added benefit for patients in comparison with chemotherapy alone.

8 Aug 2022

Optically controlled local heat-pulse method manipulates temperature in cells

A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and leads to malignant hyperthermia

8 Aug 2022

How do female sex hormones affect sleep, and memory?

Scientists describe the relationship between biological sex, memory, sleep, and hormones in relation to the risk of Alzheimer's disease and related dimentias.

7 Aug 2022

Study finds COVID associated with abnormal placental pathologies in nearly 50% of cohort

Researchers describe the impact of placental morphological changes in COVID-19 on pregnancy outcomes.

7 Aug 2022

French study on cardiovascular disease incidence during COVID pandemic and vaccination campaign

Researchers describe failures of the French healthcare system as reflected by increased hospitalizations due to certain acute cardiovascular diseases in 2021.

7 Aug 2022

UC San Diego and Rady Children’s Hospital join new study to better understand long-term impact of COVID-19

Researchers at University of California San Diego School of Medicine and Rady Children's Hospital-San Diego have joined a nationwide study to better understand the long-term impact of COVID-19 on patients in the United States across all demographic groups.

5 Aug 2022

Study reports the effects of gender and age on both 'state' and 'trait' fatigue

To study the relationship between age and fatigue, Kessler Foundation researchers conducted a novel study using neuroimaging and self-report data.

5 Aug 2022

Five-year, $2.7 million grant could help determine the best treatment for lung cancer patients

The goal: Improve survival rates for lung cancer patients. The question researchers want to answer: Are there new ways to determine the best treatment for these patients?

5 Aug 2022

Research suggests a new nanomedicine strategy for treatment of IBD patients

Inflammatory bowel disease (IBD), also known as "green cancer", is a chronic, non-specific disease of the intestine. IBD includes ulcerative colitis and Crohn's disease, both of which tend to be debilitating, lifelong conditions that can prove fatal in severe cases. Currently, there is no cure for IBD. The main clinical treatments are drugs such as aminosalicylic acid preparations and corticosteroids, but they are often accompanied by gastrointestinal problems, anemia, and various intestinal complications. Finding alternative, more effective options is a priority for researchers.

5 Aug 2022

Researchers delve deeper into the structure of protein receptor crucial for cardiovascular health

5 Aug 2022

Study reveals the ill effects of common air pollutants on pregnant women and their unborn children

Mild exposure to common smog pollutants such as inhalable airborne particles and carbon monoxide during pregnancy results in adverse maternal and fetal health outcomes, a new study of women in China finds.

5 Aug 2022

Vitamin B12, folic acid supplements could potentially halt or reverse advanced form of fatty liver disease

Scientists at Duke-NUS Medical School in Singapore have uncovered a mechanism that leads to an advanced form of fatty liver disease - and it turns out that vitamin B12 and folic acid supplements could reverse this process.

5 Aug 2022

Elevated stress during the pandemic impacted the quality of life for kids with headache disorders

Since the beginning of the COVID-19 pandemic, many pediatric patients who suffer from headaches have experienced more frequent headaches and worsening anxiety and mood, and a new study finds links to stress, decreased physical activity and increased screen time.

5 Aug 2022

Study sheds light on the pathogenic brain mechanisms associated with evolution of anxiety

Monoamine neurotransmitters such as serotonin and dopamine play important roles in our cognitive and emotional functions.

5 Aug 2022

Medical Research News

Researchers create a physical wiring diagram of the human immune system

How can we map the human genetic architecture of COVID-19 across all ancestry groups?

Boosting vitamin D in individuals with deficiencies likely to reduce chronic inflammation

Implantable mechanotherapeutic drug delivery platform helps overcome host immune response

Terminally exhausted T cells may remain competent for transcription, researchers say

Wrist-wearable devices more cost-effective than electrocardiograms and pulse palpation for atrial fibrillation screening

Nivolumab approved for combination with fluoropyrimidine- and platinum-based combination chemotherapy

Optically controlled local heat-pulse method manipulates temperature in cells

How do female sex hormones affect sleep, and memory?

Study finds COVID associated with abnormal placental pathologies in nearly 50% of cohort

French study on cardiovascular disease incidence during COVID pandemic and vaccination campaign

UC San Diego and Rady Children’s Hospital join new study to better understand long-term impact of COVID-19

Study reports the effects of gender and age on both 'state' and 'trait' fatigue

Five-year, $2.7 million grant could help determine the best treatment for lung cancer patients

Research suggests a new nanomedicine strategy for treatment of IBD patients

Researchers delve deeper into the structure of protein receptor crucial for cardiovascular health

Study reveals the ill effects of common air pollutants on pregnant women and their unborn children

Vitamin B12, folic acid supplements could potentially halt or reverse advanced form of fatty liver disease

Elevated stress during the pandemic impacted the quality of life for kids with headache disorders

Study sheds light on the pathogenic brain mechanisms associated with evolution of anxiety

Membrane proteins in focus: Turning high-risk targets into routine workflows

How metabolic phenotyping can detect viral infections in minutes

Directed enzyme evolution and the Nobel Prize: Making enzymes evolve in the lab

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