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People living with HIV/AIDS more likely to have suicidal thoughts and die from suicide

A new study by researchers at Penn State College of Medicine indicates that people living with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) - approximately 38 million worldwide - are more likely to have suicidal thoughts and die from suicide than members of the general population.

28 Jun 2021

Gene variant in African Americans contributes to unnecessary bone marrow biopsies

A gene variant that lowers white blood cell levels and is common in individuals with African ancestry contributes to unnecessary bone marrow biopsies, according to a study published June 28 in JAMA Internal Medicine.

28 Jun 2021

Researchers develop engineered yeast probiotic for treatment of inflammatory bowel disease

The world of microbes living in the human gut can have far-reaching effects on human health. Multiple diseases, including inflammatory bowel disease (IBD), are tied to the balance of these microbes, suggesting that restoring the right balance could help treat disease.

28 Jun 2021

UK study finds SARS-CoV-2 antibodies in domestic cats and dogs

Researchers analyzed sera from pet cats and dogs and found them to have developed antibodies against the virus later on during the COVID-19 pandemic. These findings suggest that viral prevalence among the human populations could have led to the pets becoming infected.

28 Jun 2021

Study associates higher antibody titers with naïve B cells post-mRNA vaccination

Researchers compared peripheral blood mononuclear cells in people with high and low antibody titers after two doses of the Pfizer/BioNTech (BNT162b2) mRNA vaccine. They found a positive correlation between naïve B cells present before vaccination and high antibody titers.

28 Jun 2021

Resting heart rate variability predicts emotional resilience during COVID-19 restrictions

An interesting new study available as a preprint on the medRxiv* server suggests that vagally-mediated heart rate variability (vmHRV) is a physiological marker of resilience to stress by indicating how well an individual handles the emotions when faced with changes in the surroundings.

28 Jun 2021

Could microalgae-derived antiviral compounds combat SARS-CoV-2 and other viruses?

A new review article published in the journal Antibiotics reports the presence of a large number of bioactive compounds in microalgae that target chemical structures present only in their structure.

28 Jun 2021

Vaccines and drugs must be adapted to combat emerging SARS-CoV-2 variants, says study

A new review of the emerging variants of concern (VOCs) of the SARS-CoV-2, which has caused the COVID-19 pandemic, shows that there is a major need to constantly re-evaluate the utility of existing therapeutics and vaccines against the virus and to develop new ones.

28 Jun 2021

COVID-19 patients with traumatic injuries have six times higher risk of complications, death

In addition to sickening and taking the lives of millions across the globe, COVID-19 complicated patient care in a range of less-direct ways, from increased incidence of heart attacks to decreased cancer screenings.

28 Jun 2021

Study examines effect of sorafenib in patients with advanced hepatocellular carcinoma

Oncotarget published "Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib" which reported that this study investigated the association of the IGF/CTP score with overall survival and progression-free survival of HCC patients treated with sorafenib.

28 Jun 2021

Promising immunotherapy uses cancer-killing cells to destroy malignant tumors

Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumors.

28 Jun 2021

Anti-cancer prodrug can benefit cancer patients

Unlike conventional cancer drugs that attack and kill cancer cells directly, anti-cancer immunotherapy, which kills cancer cells by strengthening the body's immunity, is a novel type of cancer treatment currently attracting increased attention. Unfortunately, a minority of cancer patients who have some degree of pre-existing immunity only benefit from anti-cancer immunotherapy.

28 Jun 2021

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Oncotarget published "Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells" which reported that to guide studies in cancer patients, relacorilant, an investigational selective GR modulator that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

28 Jun 2021

Study explores the potential role of gene polymorphisms in pathogenesis of prostate cancer

Oncotarget published "The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia" reported that polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time corresponding to unfavorable and favorable disease prognosis respectively.

28 Jun 2021

Mutation-signature–associated metrics predict cancer progression in patients

Oncotarget published "Predicting clinical outcomes using cancer progression associated signatures" which reported somatic mutation signatures are an informative facet of cancer etiology, however they are rarely useful for predicting patient outcome.

28 Jun 2021

Tocilizumab and sarilumab shown to be effective in critical COVID-19

A new study, released as a preprint on the medRxiv* server, describes how a team of researchers from the University Medical Center Utrecht in the Netherlands explored the efficacy of four monoclonal antibodies that antagonize powerful pro-inflammatory pathways. The team sought to determine which were useful in treating critically ill COVID-19 patients on organ support.

28 Jun 2021

An affordable, scalable and highly sensitive virus-genome-based testing approach

Aiming to reduce human suffering, economic costs, and restrictions on personal freedom caused by COVID-19 to a minimum, researchers from Germany and Austria proposed an alternative method - efficient population-based genome-based testing.

28 Jun 2021

Oxford-AstraZeneca COVID-19 vaccine induces robust T cell-based immunity

A recent study conducted by an international team of scientists has revealed that the Oxford-AstraZeneca coronavirus disease 2019 (COVID-19) vaccine, AZD1222, is capable of inducing strong spike-specific CD4+ T cell helper type 1 (Th1) and CD8+ T-cell responses in vaccinated individuals. A detailed description of AZD1222-induced cellular immunity is currently available on the medRxiv* preprint server.

28 Jun 2021

Heart failure can increase cancer risk

A study in more than 200,000 individuals has found that patients with heart failure are more likely to develop cancer compared to their peers without heart failure.

28 Jun 2021

Why SARS-CoV-2 delta variant is more infectious

German experts recently explained why the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant is more infectious and pathogenic than its ancestor. By conducting a series of in vitro experiments, they have revealed that increased ability to induce cell-to-cell fusion (syncytia) and reduced susceptibility to vaccine and infection-induced antibodies make the delta variant more infectious than previously circulating variants. The study is currently available on the bioRxiv* preprint server.

28 Jun 2021

Medical Research News

People living with HIV/AIDS more likely to have suicidal thoughts and die from suicide

Gene variant in African Americans contributes to unnecessary bone marrow biopsies

Researchers develop engineered yeast probiotic for treatment of inflammatory bowel disease

UK study finds SARS-CoV-2 antibodies in domestic cats and dogs

Study associates higher antibody titers with naïve B cells post-mRNA vaccination

Resting heart rate variability predicts emotional resilience during COVID-19 restrictions

Could microalgae-derived antiviral compounds combat SARS-CoV-2 and other viruses?

Vaccines and drugs must be adapted to combat emerging SARS-CoV-2 variants, says study

COVID-19 patients with traumatic injuries have six times higher risk of complications, death

Study examines effect of sorafenib in patients with advanced hepatocellular carcinoma

Promising immunotherapy uses cancer-killing cells to destroy malignant tumors

Anti-cancer prodrug can benefit cancer patients

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Study explores the potential role of gene polymorphisms in pathogenesis of prostate cancer

Mutation-signature–associated metrics predict cancer progression in patients

Tocilizumab and sarilumab shown to be effective in critical COVID-19

An affordable, scalable and highly sensitive virus-genome-based testing approach

Oxford-AstraZeneca COVID-19 vaccine induces robust T cell-based immunity

Heart failure can increase cancer risk

Why SARS-CoV-2 delta variant is more infectious

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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