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Forkhead box O's potential therapeutic use in the treatment of COVID-19

In a recent study, Indian researchers from the Department of Biochemistry, University of Delhi, reviewed a possible vital coalition of FoxOs - the Forkhead Box O subfamily of protein transcription factors, with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological agent of COVID-19 (coronavirus disease).

13 Jun 2021

What makes the elderly more susceptible to SARS-CoV-2 infection?

Why is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 (coronavirus disease 2019), biased towards infecting the aged population? A recently published study by Italian scientists linked aging, DNA damage, telomere shortening, and increased levels of angiotensin-converting enzyme 2 (ACE2) to this relationship.

13 Jun 2021

Teachers and school staff should be prioritised for COVID vaccines

In a communication paper recently published in the Journal of Paediatrics and Child Health by Koirala et al. (June 8th, 2021), it is argued that Australian schools should remain open, with proper testing, tracing, and quarantine protocols in place.

13 Jun 2021

Philippines poorly prepared to deal with COVID-19, report says

In a recent study published in the WHO WPSAR journal, researchers described the challenges and early response of the Philippines to COVID-19.

13 Jun 2021

Role of traditional medicine against SARS-CoV-2

A group of researchers at Kannur University reviewed selected papers and in silico work on potential drug leads that could be used to manage COVID-19.

13 Jun 2021

Humoral innate pattern recognition molecules against SARS-CoV-2

In a paper recently uploaded to the preprint server medRxiv by Garlanda et al. (June 8th, 2021), humoral pattern recognition molecules are explored for affinity towards SARS-CoV-2, contributing to unraveling the role of these molecules in COVID-19 disease progression.

13 Jun 2021

Long-range airborne transmission of SARS-CoV-2

In an early release copy of a short commentary paper recently published in the Canadian Medical Association Journal by Addleman et al. (June 8th, 2021), the impact of, and possible solutions to, the short- and long-range airborne transmission of SARS-CoV-2 are explored.

13 Jun 2021

An analysis links COVID-19 to brain microvascular injury and inflammation

The ongoing COVID-19 pandemic is caused by the severe acute respiratory syndrome-2 (SARS-CoV-2), an RNA virus that belongs to the family Coronaviridae. According to research, coronavirus disease 2019 (COVID-19) patients often suffer from neurological disorders like strokes, lost taste or smell, memory loss, confusion, and delirium.

13 Jun 2021

Study reveals maternal and neonatal benefits of Pfizer COVID-19 mRNA vaccine

A new commentary, published as an ‘In-Press Preview’ in the Journal of Clinical Investigation, addresses the salient issue of vaccination against the coronavirus disease (COVID-19) in pregnancy and potential antibody transfer to the fetus – and provides the evidence in support of messenger RNA (mRNA) vaccine safety and efficacy for both maternal and child health.

13 Jun 2021

Study shows poor antibody response in naive elderly of nursing homes after mRNA vaccination

A new study describes inadequate antibody responses to the Pfizer/BioNTech vaccine against coronavirus disease 2019 (COVID-19) in elderly residents of a care home with no prior history of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), compared to those with such a history. This adds to the current understanding of vaccine efficacy against infection.

13 Jun 2021

New radiopharmaceutical shows therapeutic efficacy in preclinical model of ovarian cancer

Preclinical trials of a new radiopharmaceutical to treat ovarian cancer have produced successful results, dramatically limiting tumor growth and decreasing tumor mass.

11 Jun 2021

Study shows feasibility of using Olfactory Virtual Reality to address anxiety, pain and stress

Findings from a study on the feasibility of addressing anxiety, pain and stress with Olfactory Virtual Reality (OVR) - a new form of VR that incorporates the sense of smell into its augmented reality - paint a clearer picture for clinical psychiatrists about how it could be used to safely and effectively help mental health and mood disorders.

11 Jun 2021

AI identifies gene signatures to reveal patients’ immune responses to viral infection

Researchers at University of California San Diego School of Medicine used an artificial intelligence (AI) algorithm to sift through terabytes of gene expression data -- which genes are "on" or "off" during infection -- to look for shared patterns in patients with past pandemic viral infections, including SARS, MERS and swine flu.

11 Jun 2021

Children of well-educated parents survive more often than others

Every day, around 15000 children under the age of five die from causes that could have been prevented.

11 Jun 2021

High single-dose efficacy of Pfizer vaccine against SARS-CoV-2 in older adults

In British Columbia (BC), Canada, vaccination against coronavirus disease 2019 (COVID-19) began with the Pfizer/Moderna mRNA (messenger ribonucleic acid) vaccines began with nursing home residents and frontline healthcare workers. These are known to have a high protective efficacy of 92-93% after a single dose, but this data comes from younger and healthy adults, for the most part.

11 Jun 2021

New Astra-Zeneca B.1.351 vaccine AZD2816 strongly immunogenic against multiple SARS-CoV-2 variants of concern

A new study, released on the bioRxiv* preprint server, supports the efficacy of the wildtype ChAdOx1 nCoV-19 (AZD1222) vaccine against B.1.351, B.1.617.1 and B.1.617.2, while showing that a booster dose of vaccine based on the B.1.351 spike induces further increase in antibody titers.

11 Jun 2021

Has COVID-19 vaccine confidence dropped following the pause of Johnson & Johnson/Janssen?

A new study, which was conducted by Vishala Mishra and Joseph P. Dexter at Madras Medical College, Chennai, India, suggests that the infamous pause in the administration of the Johnson & Johnson (J&J)/Janssen COVID-19 vaccine, advised by the FDA, has left doubt about the veracity of vaccine safety claims. This is a development that may have engendered vaccine hesitancy in a segment of the population.

11 Jun 2021

Scientists detect delayed and reduced antibody responses after BioNTech/Pfizer COVID-19 vaccination in older adults

Researchers at the U.S. Centers for Disease Control and Prevention (CDC) detected delayed and reduced antibody and T cell responses after immunization with BNT162b2 or the Pfizer-BioNTech COVID-19 vaccine in older adults compared with healthcare workers in Germany.

11 Jun 2021

SARS-CoV-2 infection detected in a poodle living with a COVID-19 positive family

Researchers in Italy identified a case of reverse zoonosis wherein animals contract the virus from humans. The team detected SARS-CoV-2 in a healthy poodle living with four family members who had COVID-19.

11 Jun 2021

Naked mole rats may hold the key to new treatments for cancer, dementia

Scientists say naked mole rats - a rodent native to West Africa - may hold the key to new treatments for degenerative diseases such as cancer and dementia. The reclusive animals have a lifespan far in excess of other rodents - for example, mice and rats live about two years, whereas naked mole rats can live for 40 or 50 years.

11 Jun 2021

Medical Research News

Forkhead box O's potential therapeutic use in the treatment of COVID-19

What makes the elderly more susceptible to SARS-CoV-2 infection?

Teachers and school staff should be prioritised for COVID vaccines

Philippines poorly prepared to deal with COVID-19, report says

Role of traditional medicine against SARS-CoV-2

Humoral innate pattern recognition molecules against SARS-CoV-2

Long-range airborne transmission of SARS-CoV-2

An analysis links COVID-19 to brain microvascular injury and inflammation

Study reveals maternal and neonatal benefits of Pfizer COVID-19 mRNA vaccine

Study shows poor antibody response in naive elderly of nursing homes after mRNA vaccination

New radiopharmaceutical shows therapeutic efficacy in preclinical model of ovarian cancer

Study shows feasibility of using Olfactory Virtual Reality to address anxiety, pain and stress

AI identifies gene signatures to reveal patients’ immune responses to viral infection

Children of well-educated parents survive more often than others

High single-dose efficacy of Pfizer vaccine against SARS-CoV-2 in older adults

New Astra-Zeneca B.1.351 vaccine AZD2816 strongly immunogenic against multiple SARS-CoV-2 variants of concern

Has COVID-19 vaccine confidence dropped following the pause of Johnson & Johnson/Janssen?

Scientists detect delayed and reduced antibody responses after BioNTech/Pfizer COVID-19 vaccination in older adults

SARS-CoV-2 infection detected in a poodle living with a COVID-19 positive family

Naked mole rats may hold the key to new treatments for cancer, dementia

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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