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Refining the diagnosis of large granular lymphocytic leukemias and their mimics

Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders characterized by the clonal proliferation of cytotoxic lymphocytes. Among them, T-cell LGLL (T-LGLL) and NK-cell LGLL (NK-LGLL) are the most prominent.

10 Apr 2025

Coaxial silicone drains reduce pain after VATS lobectomy without compromising efficacy

Chest drains are routinely used after video-assisted thoracoscopic surgery (VATS) lung resections to evacuate fluid and air from the pleural space.

10 Apr 2025

Researchers uncover why fat gain happens fast during life changes

Perspective article proposes that major fat gains arise from short-term lifestyle disruptions rather than gradual daily surpluses. The authors call for public health strategies to focus on preventing episodic weight spikes during high-risk life events.

10 Apr 2025

Survey reveals diverse practices in thoracic sympathetic surgery across Europe

Thoracic autonomic nervous system surgery is mainly used for hyperhidrosis/facial flushing, whereas cardiac and vascular indications are limited.

10 Apr 2025

Researchers explore drug repurposing strategy for Parkinson's disease

Despite significant advances in Parkinson's disease (PD) treatment, it remains incurable, with limited therapeutic options.

10 Apr 2025

Study reveals how the brain balances hormones and metabolism during lactation

Nursing poses major metabolic demands on mothers, to which they respond by eating more and saving energy to sustain milk production.

10 Apr 2025

Exploring the complex association between anemia and retinopathy of prematurity

Anemia is a common condition in premature infants, particularly those at risk for retinopathy of prematurity (ROP).

10 Apr 2025

England faces persistent rise in alcohol deaths

The persistent higher rate of alcohol deaths in England since the pandemic in 2020 is an "acute crisis" requiring urgent action from government, according to a new study led by researchers at UCL and the University of Sheffield.

10 Apr 2025

Alcohol reshapes reward learning differently in male and female rats

Chronic alcohol exposure causes lasting impairments in decision-making in male rats, altering how the brain processes reward-based learning. A new study reveals sex-specific neural changes in the striatum, with female rats showing resilience despite altered brain activity.

10 Apr 2025

Understanding key risk factors behind shoulder injuries in athletes and aging adults

Shoulders are, in many ways, a marvel. One shoulder has four separate joints, packed with muscles, that allow us to move our arm in eight different major ways, giving us the most degrees of freedom of any joint in the body.

10 Apr 2025

Study reveals brain circuit behind apathy in advanced cancer

The fatigue and lack of motivation that many cancer patients experience near the end of life have been seen as the unavoidable consequences of their declining physical health and extreme weight loss.

10 Apr 2025

Unlocking the power of MDA5 protein modifications in antiviral defense

Cleveland Clinic virology researchers have found that a specific protein modification to the immune protein MDA5 is key to how human bodies detect and respond to viruses and viral replication.

10 Apr 2025

Genetic test outperforms PSA and MRI in spotting deadly prostate cancer early

A UK study found that using a polygenic risk score to identify men at highest genetic risk of prostate cancer significantly improved detection of clinically important disease. This approach caught aggressive cancers that standard PSA and MRI screening would have missed.

10 Apr 2025

Can psychedelics break compulsive eating habits in obesity?

A review by Oxford researchers explores how psychedelics like psilocybin and LSD may help disrupt compulsive eating behaviors in subsets of obese individuals. The paper outlines proposed neurobiological, epigenetic, and gut-brain mechanisms while emphasizing the need for human trials.

10 Apr 2025

Combined use of alcohol and cannabis could fuel addiction risks

Many young adults drink alcohol and use cannabis together, at the same time, as a coping mechanism or to relieve stress.

10 Apr 2025

Six early life factors found to influence obesity risk in South Asian children

Researchers at McMaster University have identified six key factors in the first three years of life that influence the trajectory of obesity in South Asian children.

10 Apr 2025

Epigenetic discovery offers hope for reducing addiction relapse

New research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and thereby the formation of strong drug-related memories, which can trigger relapse in individuals with substance use disorders (SUDs).

10 Apr 2025