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Study: Mavacamten improves heart function in patients with hypertrophic cardiomyopathy

Mavacamten improves heart function and symptoms in patients with obstructive hypertrophic cardiomyopathy, according to results of the EXPLORER-HCM trial presented in a Hot Line session today at ESC Congress 2020.

31 Aug 2020

DAPA-CKD trial shows dapagliflozin reduces risk of chronic kidney disease

Dapagliflozin reduces the risk of kidney failure, death from cardiovascular causes or heart failure hospitalization and all-cause mortality in chronic kidney disease patients with or without type 2 diabetes.

31 Aug 2020

Premenopausal women have favorable long-term outcomes after heart attack, shows study

Premenopausal women have good long-term outcomes after a heart attack, according to late breaking research presented today at ESC Congress 2020.

31 Aug 2020

IL-6 signaling blockade can alleviate severe COVID-19

A team of researchers led by Osaka University find an overlap in the pathogenesis of cytokine release syndrome and COVID-19, and show that the symptoms of both can be alleviated by IL-6 signaling blockade

31 Aug 2020

Trimetazidine does not improve outcomes in patients with chronic or acute coronary syndromes

Trimetazidine administered after successful percutaneous coronary intervention (PCI) does not improve outcomes in patients with chronic or acute coronary syndromes, according to results of the ATPCI trial presented in a Hot Line session today at ESC Congress 2020.

31 Aug 2020

Study: Preventive medications reduce risk of heart attacks in diabetic patients

Dramatic reductions in the risk of heart attacks in patients with diabetes coincides with major increases in the use of preventive medications. That's the finding of late breaking research presented today at ESC Congress 2020.

31 Aug 2020

Cat antiviral that inhibits SARS-CoV-2 fast-tracked for human clinical trials

Now, a team of researchers at the University of Alberta in Canada has identified viral inhibitors that they claim are potential candidates as a treatment for COVID-19. The team is set to launch clinical trials of the drug that is used as a treatment for a type of coronavirus in cats.

31 Aug 2020

Researchers identify roles of matrix stiffness and mechanotransduction in cardiac reprogramming

Cardiovascular disease is the leading cause of death in humans. Worldwide, as the population ages, the burden of treating heart failure is increasing; opportunities for heart transplantation cannot keep pace.

31 Aug 2020

Serum protein shows therapeutic value against severe COVID-19-like features in mouse model

A new study published on the preprint server bioRxiv* in August 2020 reports the disease-mitigating effects of a serum protein called serum amyloid P (SAP) in mice exposed to a peptide that mimics the clinical signs of severe COVID-19 in humans.

30 Aug 2020

New lipid derivatives of Remdesivir have higher anti-coronavirus activity

In a fascinating new preprint paper published on bioRxiv* in August 2020, the researchers report “the synthesis and antiviral evaluation of three novel lipophilic prodrugs of RVn-monophosphate that are substantially more active than Remdesivir in cells infected with SARS-CoV-2.” These could be of immense use in treating COVID-19 patients early and helping to end transmission.

30 Aug 2020

Rabbits susceptible to SARS-CoV-2: Red flag for potential virus reservoir

A new study by scientists in the Netherlands and published on the preprint server bioRxiv* in August 2020 shows that the severe acute respiratory coronavirus-2 (SARS-CoV-2) can infect rabbits, which opens the door for possible circulation in rabbit farms and another potential source of animal to human SARS-CoV-2 infection. This finding calls for urgent research on the prevalence of the virus in farmed rabbits.

30 Aug 2020

Using SARS-CoV-2 epitope to construct a vaccine

A new study published on the preprint server bioRxiv* in August 2020 reports the use of prediction and advanced simulation techniques to identify a novel T cell epitope on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could serve as the basis for a customized vaccine with broad-based efficacy.

30 Aug 2020

SARS-CoV-2 Neucleocapside (N) protein is heavily glycosylated

However, the nucleocapsid (N) protein is also extremely abundant and, therefore, a useful target for both vaccine and diagnostic test development. A new study published on the preprint server bioRxiv in August 2020 reveals the structure of this protein, a valuable step in using it for these purposes.

30 Aug 2020

Severe and fatal COVID-19 is rare in children

Now, a new study by researchers at the Universities of Edinburgh and Liverpool, Imperial College London, and the Royal Hospital for Children, Glasgow in the United Kingdom has shown that children and teenagers are less likely than adults to develop severe COVID-19 or die from the disease.

30 Aug 2020

Evidence of SARS-CoV-2 spreading in an airplane toilet

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease (COVID-19), is still actively spreading like wildfire, with nearly 300,000 new infections reported daily across the globe. Early on in the outbreak in China, scientists said that the virus could spread through respiratory droplets, when a person coughs, sneezes, or speaks.

30 Aug 2020

Medical Research News

Study: Mavacamten improves heart function in patients with hypertrophic cardiomyopathy

DAPA-CKD trial shows dapagliflozin reduces risk of chronic kidney disease

Premenopausal women have favorable long-term outcomes after heart attack, shows study

IL-6 signaling blockade can alleviate severe COVID-19

Trimetazidine does not improve outcomes in patients with chronic or acute coronary syndromes

Study: Preventive medications reduce risk of heart attacks in diabetic patients

Cat antiviral that inhibits SARS-CoV-2 fast-tracked for human clinical trials

Researchers identify roles of matrix stiffness and mechanotransduction in cardiac reprogramming

Serum protein shows therapeutic value against severe COVID-19-like features in mouse model

New lipid derivatives of Remdesivir have higher anti-coronavirus activity

Rabbits susceptible to SARS-CoV-2: Red flag for potential virus reservoir

Using SARS-CoV-2 epitope to construct a vaccine

SARS-CoV-2 Neucleocapside (N) protein is heavily glycosylated

Severe and fatal COVID-19 is rare in children

Evidence of SARS-CoV-2 spreading in an airplane toilet

Atheists and agnostics more likely to be better sleepers than Catholics, Baptists

Sleep loss unleashes anger, shows study

Clinicians may have to look beyond opioids to tackle nation’s substance use epidemic

Host tissue T cells play a previously unappreciated role in acute graft-versus-host disease

International research network aims to understand how animals use odors to guide behavior

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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