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Research shows how remdesivir inhibits SARS-CoV-2 replication

In a recent bioRxiv preprint, a research team from Germany, Goran Kokic et al. study the molecular mechanism of remdesivir-induced stalling of RdRp - using synthetic RNA chemistry, biochemistry, and cryo-electron microscopy.

2 Nov 2020

Ethacridine blocks SARS-CoV-2 with a distinct mode of action

Now, researchers from the University of California, San Francisco, and Stanford University, California, USA, reported a safe and potent antiseptic for use in humans named ethacridine, which effectively inhibits SARS-CoV-2 even at very low concentrations of EC50 ~ 0.08 µM. Their work has is published on the preprint server bioRxiv*.

1 Nov 2020

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Researchers tested 5-amino levulinic acid in vitro in human-derived cells and found it prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because it is safe and ubiquitous in plants and animals, it could be a potential drug against SARS-CoV-2.

1 Nov 2020

Drug used to control blood pressure may improve cancer patients’ response to immunotherapy

The same biochemical triggers that spur a "fight or flight" response when we encounter threats may help tumor cells to thrive.

30 Oct 2020

SARS-CoV-2 virus may target red marrow and prevent the formation of new erythrocytes

Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.

30 Oct 2020

First-of-its-kind synthetic DNA vaccine designed against Powassan virus

Scientists at The Wistar Institute have designed and tested the first-of-its-kind synthetic DNA vaccine against Powassan virus (POWV), targeting portions of the virus envelope protein.

30 Oct 2020

Researchers seek to understand HIV-related attitudes of nursing faculty in six countries

Since the earliest study about nursing faculty and students attitudes and beliefs about caring for people living with HIV/AIDS (PLHIV) in the early 1990's, there have only been 17 additional studies. Knowledge in this area of study is still lacking to fill some gaps in understanding attitudes towards people living with the disease.

30 Oct 2020

Potential treatment might make tumors more responsive to immunotherapy

Cancer immunotherapies, which empower patients' immune systems to eliminate tumors, are revolutionizing cancer treatment. Many patients respond well to these treatments, sometimes experiencing long-lasting remissions.

30 Oct 2020

Glucose-lowering drugs have neutral effect on mortality, adverse outcomes in COVID-19 patients with type 2 diabetes

In a preprint paper, "Impact of Glucose-Lowering Drugs on Mortality and Other Adverse Outcomes in Patients with Type 2 Diabetes Admitted for COVID-19," researchers conclude a neutral effect on mortality and other adverse outcomes.

30 Oct 2020

Researchers report a novel approach to generate T-cells faster

Adoptively transferred T-cells can prolong survival and sometimes cure patients with advanced solid tumors. While promising, it can take months to generate the necessary T-cells to help these patients. Such slow speed makes this therapy impractical for most patients who need immediate treatment.

30 Oct 2020

COVID-19 spreads faster and more widely in U.S. households, finds study

COVID-19 spreads faster and more widely throughout U.S. households than previously reported, according to new preliminary research from a multicenter study led by Vanderbilt University Medical Center researchers and published in MMWR, a weekly report from the Centers for Disease Control and Prevention.

30 Oct 2020

Researchers identify new drug candidate with potential to treat COVID-19

Researchers from the University of Kent, the Goethe-University in Frankfurt am Main (Germany), and the Hannover Medical School (Germany) have identified a drug with the potential to provide a treatment for COVID-19.

30 Oct 2020

Study identifies new cause of inflammation in people living with HIV

While current antiretroviral treatments for HIV are highly effective, data has shown that people living with HIV appear to experience accelerated aging and have shorter lifespans - by up to five to 10 years - compared to people without HIV.

30 Oct 2020

E-health app supported care improves COPD outcomes compared to usual treatment

COPD is a common respiratory condition and one of the top causes of hospital admissions each year, particularly during winter months. In the UK it accounts for over 140,000 hospital admissions and one million bed days at a major cost to the NHS.

30 Oct 2020

Children with minor perinatal brain bleeds have normal cognitive development at two years of age

In 2007, UNC researchers published unexpected and surprising results from a study based on magnetic resonance imaging (MRI) of newborn brains.

30 Oct 2020

Cancer patients, clinicians benefit when symptoms are reported using a electronic real-time system

Both cancer patients and their medical teams found it beneficial when patients shared their symptoms in real time using a web- or telephone-based reporting system, according to a national multi-institutional study.

30 Oct 2020

Neuroscientists show how the brain manages to adapt in people born without a corpus callosum

One in 4,000 people is born without a corpus callosum, a brain structure consisting of neural fibers that are used to transfer information from one hemisphere to the other.

30 Oct 2020

New project to develop surgical technologies for COVID-19 receives €2.4 million funding

Irish medical tech firm Palliare leads EU H2020 research project with UCD using innovative optical technology for new safer surgery solution.

30 Oct 2020

Researchers develop new, improved human-skin equivalent

Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) have developed an improved human-skin equivalent that reproduces traction-force balance in the lateral direction, a property that controls the structure and physiological function of skin.

30 Oct 2020

People exposed to chemical warfare agents feel uncertain about family building

People who have been exposed to chemical warfare agents (CWAs) feel uncertain, decades after the exposure, about their survival and ability to build a family, a University of Gothenburg study shows. Women are more severely affected than men.

30 Oct 2020

Medical Research News

Research shows how remdesivir inhibits SARS-CoV-2 replication

Ethacridine blocks SARS-CoV-2 with a distinct mode of action

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Drug used to control blood pressure may improve cancer patients’ response to immunotherapy

SARS-CoV-2 virus may target red marrow and prevent the formation of new erythrocytes

First-of-its-kind synthetic DNA vaccine designed against Powassan virus

Researchers seek to understand HIV-related attitudes of nursing faculty in six countries

Potential treatment might make tumors more responsive to immunotherapy

Glucose-lowering drugs have neutral effect on mortality, adverse outcomes in COVID-19 patients with type 2 diabetes

Researchers report a novel approach to generate T-cells faster

COVID-19 spreads faster and more widely in U.S. households, finds study

Researchers identify new drug candidate with potential to treat COVID-19

Study identifies new cause of inflammation in people living with HIV

E-health app supported care improves COPD outcomes compared to usual treatment

Children with minor perinatal brain bleeds have normal cognitive development at two years of age

Cancer patients, clinicians benefit when symptoms are reported using a electronic real-time system

Neuroscientists show how the brain manages to adapt in people born without a corpus callosum

New project to develop surgical technologies for COVID-19 receives €2.4 million funding

Researchers develop new, improved human-skin equivalent

People exposed to chemical warfare agents feel uncertain about family building

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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