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Mapping genetic links between diseases using data from electronic health records

Physicians use standard disease classifications based on symptoms or location in the body to help make diagnoses. These classifications, called nosologies, can help doctors understand which diseases are closely related, and thus may be caused by the same underlying issues or respond to the same treatments.

9 Dec 2019

New strategies needed to manage ibrutinib-related toxicities in CLL patients, study suggests

New findings by Yale Cancer Center and Smilow Cancer Hospital researchers show that as the use of the drug ibrutinib climbs in patients with chronic lymphocytic leukemia, so do the rates of patients who stop taking the drug.

9 Dec 2019

'Achilles' heel' of deadly superbug identified

A deadly superbug that infects an estimated 54,500 Americans a year has a secret weapon, a protein, that allows it to defy antibiotic treatment and immune system attacks.

9 Dec 2019

Researchers receive federal grant to study educational outcomes of children with special needs

A team of New Jersey researchers received a major federal grant to study the educational outcomes of children with special health care needs.

9 Dec 2019

Lactobacillus balances intestinal microbiome and ameliorates chronic alcohol-induced liver injury

Researchers demonstrated that Lactobacillus rhamnosus can dose-dependently reestablish a balanced intestinal microbiome and counter the liver-damaging effects of alcohol consumption in mice to reverse the results of chronic alcohol-induced liver injury.

9 Dec 2019

Study uses machine learning and health data to identify suicide risk factors

First-of-its-kind study used machine learning and health data from the entire Danish population to create sex-specific suicide risk profiles, illuminating the complex mix of factors that may predict suicide.

9 Dec 2019

Relapsed mantle cell lymphoma patients may benefit from CAR T-cell therapy

A one-year follow-up study led by The University of Texas MD Anderson Cancer Center revealed a majority of patients with mantle cell lymphoma resistant to prior therapies may benefit from treatment with CD19-targeting chimeric antigen receptor (CAR) T-cell therapy.

9 Dec 2019

Stem cell transplant following treatment with PD-1 inhibitor is safe, effective for patients with Hodgkin lymphoma

A new analysis shows that a donor stem cell transplant following treatment with an immune checkpoint inhibitor is generally safe and produces good outcomes for patients with Hodgkin lymphoma, easing concerns that these patients are at heightened risk for severe immune-related complications.

9 Dec 2019

Aspirin may no longer provide benefit as primary prevention for cardiovascular disease

A new paper in Family Practice, published by Oxford University Press, found that the widespread use of statins and cancer screening technology may have altered the benefits of aspirin use.

9 Dec 2019

Dead probiotic reduces age-related leaky gut in older mice, study finds

Scientists at Wake Forest School of Medicine have identified a dead probiotic that reduces age-related leaky gut in older mice. The study is published in the journal GeroScience.

9 Dec 2019

Penn researchers receive nearly $5 million to reduce opioid cravings

Opioid overdoses take the lives of tens of thousands of Americans annually. Two researchers from Penn State College of Medicine have received nearly $5 million from the National Institutes of Health to study whether an already-approved drug can be used to reduce cravings and prevent relapse in those struggling with opioid addiction.

9 Dec 2019

New nanoparticle innovation detects vascular calcification in atherosclerosis

Heart disease and stroke are the world's two most deadly diseases, causing over 15 million deaths in 2016 according to the World Health Organization.

9 Dec 2019

Metformin shows benefits on aging and different diseases

Researchers at McMaster University have unlocked one of the secrets behind the many benefits of metformin.

9 Dec 2019

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

New findings published Dec. 9 in Nature Biomedical Engineering from scientists at Fred Hutchinson Cancer Research Center show for the first time that a piece of small, thin metal mesh loaded with cancer-fighting immune cells shrinks tumors in preclinical models of ovarian cancer.

9 Dec 2019

Study explores Instagram users' experiences of miscarriage

About 10-20 % of all known pregnancies unfortunately end in miscarriage or the loss of a fetus. Despite its common occurrence, there is still a lot of stigma surrounding miscarriage and many women find that their emotional and psychological needs are unmet as they go through a devastating grieving process.

9 Dec 2019

Innovative experimental therapy may stop growth of triple-negative breast cancer

Mount Sinai researchers have designed an innovative experimental therapy that may be able to stop the growth of triple-negative breast cancer, the deadliest type of breast cancer, which has few effective treatment options, according to a study published in Nature Chemical Biology in December.

9 Dec 2019

Some phages employ new strategy to avoid becoming the next casualty of DNA-dicing enzymes

Bacteria and the viruses that infect them are engaged in a molecular arms race as ancient as life itself. Evolution has equipped bacteria with an arsenal of immune enzymes, including CRISPR-Cas systems, that target and destroy viral DNA. But bacteria-killing viruses, also known as phages, have devised their own tools to help them outmaneuver even the most formidable of these bacterial defenses.

9 Dec 2019

Yale study highlights the need to develop effective, less toxic approaches to treat AML patients

A new study by Yale Cancer Center researchers shows understanding treatment patterns for patients with acute myeloid leukemia is vital to develop strategies to improve outcomes.

9 Dec 2019

Neuroscientists show two nerve cells responsible for decision-making process

A penalty shootout at the Soccer World Cup. All eyes are on the best striker of the team. He should take the decisive shot, preferably past the goalkeeper. The striker must decide whether to aim for the right or left corner of the goal. In his brain, he plans both options before making the decision. If the goalkeeper's posture indicates that he will jump to the right at the decisive moment, the striker will develop a temporary preference for planning a movement to the left corner.

9 Dec 2019

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Cancer immunology drugs, which harness the body's immune system to better attack cancer cells, have significantly changed the face of cancer treatment. People with aggressive cancers are now living longer, healthier lives. Unfortunately, cancer immunology therapy only works in a subset of patients.

9 Dec 2019

Medical Research News

Mapping genetic links between diseases using data from electronic health records

New strategies needed to manage ibrutinib-related toxicities in CLL patients, study suggests

'Achilles' heel' of deadly superbug identified

Researchers receive federal grant to study educational outcomes of children with special needs

Lactobacillus balances intestinal microbiome and ameliorates chronic alcohol-induced liver injury

Study uses machine learning and health data to identify suicide risk factors

Relapsed mantle cell lymphoma patients may benefit from CAR T-cell therapy

Stem cell transplant following treatment with PD-1 inhibitor is safe, effective for patients with Hodgkin lymphoma

Aspirin may no longer provide benefit as primary prevention for cardiovascular disease

Dead probiotic reduces age-related leaky gut in older mice, study finds

Penn researchers receive nearly $5 million to reduce opioid cravings

New nanoparticle innovation detects vascular calcification in atherosclerosis

Metformin shows benefits on aging and different diseases

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

Study explores Instagram users' experiences of miscarriage

Innovative experimental therapy may stop growth of triple-negative breast cancer

Some phages employ new strategy to avoid becoming the next casualty of DNA-dicing enzymes

Yale study highlights the need to develop effective, less toxic approaches to treat AML patients

Neuroscientists show two nerve cells responsible for decision-making process

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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