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Researchers reveal massive genome havoc in breast cancer

In cancer cells, genetic errors wreak havoc. Misspelled genes, as well as structural variations -- larger-scale rearrangements of DNA that can encompass large chunks of chromosomes -- disturb carefully balanced mechanisms that have evolved to regulate cell growth.

13 Jul 2018

Whole genome sequencing shows tight clustering between bacterial isolates in returning travelers

Thirteen patients with OXA-48-producing Klebsiella pneumoniae ST392 have been reported by Sweden and Norway between January and April 2018 - all returning travellers with prior hospital admission in Gran Canaria, Spain.

13 Jul 2018

Managing multiple ipsilateral breast cancer with potential new surgical options

A new multi-institutional clinical trial compared outcomes of women with multiple ipsilateral breast cancer, or more than one site of disease in the same breast, who underwent breast-conserving surgery, with outcomes of those who converted to mastectomy.

13 Jul 2018

Neurogenesis underlies the brain's capacity for new memories

The ability to obtain new memories in adulthood may depend on neurogenesis -- the generation of new neurons in the hippocampus -- to clear out old memories that have been safely stored in the cortex, according to research in male rats published in JNeurosci.

13 Jul 2018

New study finds ticks that can carry Lyme and other tick-borne diseases

The results of a nationwide citizen scientist study, sponsored by the Bay Area Lyme Foundation and conducted by Northern Arizona University and Colorado State University, found ticks capable of carrying Lyme and other tick-borne diseases in 83 counties throughout the country where they had not previously been recorded

13 Jul 2018

Scientists identify structural and functional differences in human immune-surveillance protein

The human body is built for survival. Each one of its cells is closely guarded by a set of immune proteins armed with nearly foolproof radars that detect foreign or damaged DNA.

13 Jul 2018

Researchers develop simple method to predict premature infants at risk for retinopathy

A multi-hospital collaboration led by researchers at Children's Hospital of Philadelphia has found a simple method of determining which premature infants should be screened for retinopathy of prematurity.

13 Jul 2018

Calcium electrotransfer could be used to target cancer cells, study finds

Several different treatment methods are used against cancer and multiple promising approaches are currently under examination by various institutions around the world.

13 Jul 2018

Virtual reality could offer psychotherapy for fear of heights, study shows

A virtual reality (VR) coach can effectively deliver psychotherapy to help overcome a fear of heights in people with this phobia.

13 Jul 2018

High opioid doses, concurrent sedative use are key factors for overdose risk in Medicaid recipients

Among Medicaid recipients taking prescription opioids, high opioid doses and concurrent treatment with benzodiazepine sedatives are among the key, potentially modifiable risk factors for fatal overdose, reports a study in the August issue of Medical Care.

13 Jul 2018

New web-based game motivates people to exercise more

A majority of American workers spend most of their day sitting and don't get enough exercise, putting them at risk for a variety of chronic diseases ranging from diabetes to cancer.

13 Jul 2018

Immunotherapies may increase overall survival in patients with melanoma brain metastases

Among patients with cutaneous melanoma who had brain metastases (MBM), first-line treatment with a checkpoint inhibitor was associated with a 1.4-fold increase in median overall survival, according to results from a national cohort.

13 Jul 2018

Imaging techniques may help assess immune system recovery in HIV patients

Findings from an animal study suggest that a non-invasive imaging technique could, with further development, become a useful tool to assess immune system recovery in people receiving treatment for HIV infection.

13 Jul 2018

Engineer patents cost-effective method to remove endotoxins from fluids

By some estimates, 18 million people die each year from sepsis triggered by endotoxins – fragments of the outer membranes of bacteria.

13 Jul 2018

Researchers solve protein puzzle that paves way for new cancer therapies

Researchers at Oregon State University have solved a longstanding puzzle concerning the design of molecular motors, paving the way toward new cancer therapies.

13 Jul 2018

New study suggests testing urine and blood serum as better way to diagnose myeloma

When it comes to diagnosing a condition in which the plasma cells that normally make antibodies to protect us instead become cancerous, it may be better to look at the urine as well as the serum of our blood for answers, pathologists say.

13 Jul 2018

Researchers find new way for producing medical therapeutic proteins

Bacterial systems are some of the simplest and most effective platforms for the expression of recombinant proteins.

13 Jul 2018

Systematic review: Role of walnut consumption on cardiovascular risk factors

An updated systematic review from Harvard University examines 25 years of evidence for the role of walnut consumption on cardiovascular risk factors, including cholesterol, triglycerides, blood pressure, and weight.

13 Jul 2018

Certain blood thinners may increase risk of bleeding in CKD patients

Certain blood thinners approved to treat atrial fibrillation may put patients with chronic kidney disease at a higher risk of bleeding, according to the results of a study in an upcoming issue of the Clinical Journal of the American Society of Nephrology.

13 Jul 2018

Preventability of hospital readmissions changes over time, study reveals

A major goal of hospitals is to prevent unplanned readmissions of patients after they are discharged. A new study reveals that the preventability of readmissions changes over time: readmissions within the first week after discharge are often preventable by the hospital, whereas readmissions later are often related to patients' difficultly accessing outpatient clinics.

13 Jul 2018