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Sweetener saccharin revives old antibiotics by breaking bacterial defences

Saccharin destabilizes bacterial membranes and interferes with DNA replication, causing lysis and impairing virulence traits. The sweetener also re-sensitizes multidrug-resistant pathogens to antibiotics and disrupts stubborn biofilms.

3 Apr 2025

Short on time? Weekend workouts still boost longevity, researchers say

A large UK Biobank study found that concentrating weekly physical activity into one or two days provides similar mortality benefits as spreading it across the week. Regular and “weekend warrior” exercise patterns both significantly reduced all-cause, cancer, and cardiovascular mortality.

3 Apr 2025

Shingles vaccine cuts dementia risk by 20%, new study shows

A large natural experiment shows that the herpes zoster vaccine reduces dementia diagnoses by 20% over seven years. The findings suggest both viral suppression and immune training may play roles in brain health.

3 Apr 2025

Study sheds light on how major cancer gene influences the success of PARP inhibitors

A study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP inhibitors.

3 Apr 2025

Laughing gas can potentially transform treatment for tough-to-beat depression

Nitrous oxide-better known as "laughing gas"-can potentially transform treatment for tough-to-beat depression.

3 Apr 2025

Study reveals how female hormones trigger opioid production for pain suppression

Scientists have discovered a new mechanism that acts via an immune cell and points toward a different way of treating chronic pain.

3 Apr 2025

Healthy lifestyle linked to lower mortality in cancer survivors

In 2022, the American Cancer Society (ACS) updated its nutrition and activity guidelines for cancer survivors, recommending they avoid obesity, stay physically active, eat a healthy diet, and limit alcohol intake.

3 Apr 2025

OICR funds five innovative cancer drug discovery projects

The Ontario Institute for Cancer Research (OICR) has announced its support for five Ontario research teams working to develop the next generation of medicines that kill tumours more effectively, cause fewer side effects and reduce the risk that cancer will come back.

3 Apr 2025

Study links neurotensin deficiency to ovulatory dysfunction in PCOS

Polycystic ovary syndrome (PCOS) represents a significant health concern for women of reproductive age, manifesting as a complex endocrine disorder with diverse clinical presentations.

3 Apr 2025

Bach2 protein identified as key regulator in atopic dermatitis

Atopic dermatitis is an allergy affecting approximately 10% of the Japanese population, with symptoms closely related to social stress.

3 Apr 2025

New CT-based score helps predict need for repeat sinus surgery

A new CT-scan based risk score facilitates the identification of patients at risk of revision endoscopic sinus surgery due to chronic rhinosinusitis.

3 Apr 2025

Targeting a key protein outside of the brain could help manage Parkinson's-related heart issues

Parkinson's doesn't just affect movement and the brain - it may also impact the heart, according to new research from the University of Surrey. Scientists from Surrey's School of Veterinary Medicine suggest that targeting a key protein outside of the brain could help manage Parkinson's-related heart issues.

3 Apr 2025

Breakthrough research identifies small peptide for psoriasis treatment

Birmingham scientists have shown that a sequence of just three amino acids may reduce the severity of psoriasis, when applied topically in an emollient cream.

3 Apr 2025

Rutgers geneticists uncover fresh insights into progression of polycystic kidney disease

For patients with polycystic kidney disease (PKD), a common genetic disorder that ravages the waste-removing organ with cysts, dialysis and transplantation are among the only treatments.

3 Apr 2025

Gut bacteria may reduce the effectiveness of common medications

A new study, published today in Nature Chemistry by researchers from the University of Pittsburgh and Yale University, shows how common gut bacteria can metabolize certain oral medications that target cellular receptors called GPCRs, potentially rendering these important drugs less effective.

3 Apr 2025