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Renal risk factors for NA-treated HBV patients identified

A South Korean research team has identified several clinical and medical factors associated with renal function decline in patients with chronic hepatitis B virus infection treated with oral nucleos(t)ide analogues.

10 Mar 2016

Real-world data confirm TDF efficacy for HBV

Treatment with tenofovir disoproxil fumarate elicits sustained virological responses and exhibits a favourable safety profile in a diverse population of patients with chronic hepatitis B virus infection, shows a French routine clinical practice study.

10 Mar 2016

Resistance to prior antiviral agents impacts TDF response

Taiwanese researchers find that virological response to tenofovir disoproxil fumarate in treatment-experienced patients with chronic hepatitis B virus infection can vary depending on the nucleos(t)ide analogue the patient is resistant to.

10 Mar 2016

Tricuspid regurgitation tied to outcomes in PAH patients

Tricuspid regurgitation progresses in line with right ventricular remodelling and increasing pulmonary artery systolic pressure in patients with pulmonary arterial hypertension, research shows.

10 Mar 2016

Hemispheric and thalamic volumes point to electrical epilepticus during sleep

Early assessment of hemispheric and thalamic volumes in children with polymicrogyria and epilepsy can reliably predict the risk of continuous spike-and-wave complexes during sleep, a study indicates.

10 Mar 2016

Regulatory immune cells compromised in PAH

Research suggests that regulatory T cells may play a part in all subtypes of pulmonary arterial hypertension.

10 Mar 2016

PAH role proposed for left heart failure biomarker

Levels of galectin-3 are elevated in patients with pulmonary arterial hypertension and correlate with disease severity, research shows.

10 Mar 2016

Integrative approach critical in addressing teen health issues

As rural communities struggle to obtain access to health services, a Kansas State University student is researching how medical, dental, social work and mental health providers can collaborate to meet the needs of teens.

10 Mar 2016

MGH researchers identify how Shigella injects proteins into target host cells

Researchers from the Massachusetts General Hospital Division of Infectious Diseases are investigating the mechanism by which several important pathogenic species of bacteria deliver proteins into the cells of the organisms they are infecting.

10 Mar 2016

Nearly half of African-American adults at risk of developing hypertension

The stats are too familiar: Nearly half of African-American adults are at risk of developing hypertension, a rate significantly higher than that of any other group in the United States. Hypertension-related ailments, such as strokes and end-stage renal disease, account for 20 percent of all deaths among African-Americans.

10 Mar 2016

Early childhood sleep problems predict later school adjustment

A child who soothes themselves back to sleep from an early age adjusts to school more easily than those who don't, new QUT research has found.

10 Mar 2016

High coronary artery calcium score puts people at greater risk for cancer, kidney disease and COPD

A 10-year follow-up study of more than 6,000 people who underwent heart CT scans suggests that a high coronary artery calcium score puts people at greater risk not only for heart and vascular disease but also for cancer, chronic kidney disease and chronic obstructive pulmonary disease (COPD).

10 Mar 2016

HIV-positive individuals in Africa with certain genetic variant have lower chance of developing TB

In the first known discovery of its kind, a Case Western Reserve University School of Medicine-led team has found that HIV patients in Africa with a certain genetic variant have a 63-percent lower chance of developing tuberculosis than HIV patients without the genetic variant.

10 Mar 2016

New imaging approach could aid earlier diagnosis of diseases

Scientists have devised a technique for visualising tissues that could aid diagnosis and treatment of diseases including cancer.

10 Mar 2016

Short intervention program can lead to significant reduction in relational bullying among preschoolers

Physical and relational bullying can happen among children as young as 3- to 5-years-old, but the results of a new study suggest that a relatively short intervention program recently developed by researchers at the University at Buffalo can lead to significant reductions in some of these behaviors.

10 Mar 2016

New vaccine delays effects of nicotine within first 10 minutes after injection

Many people who smoke want to quit, but the urge to light up is often irresistible. An effective vaccine to help people kick the habit once and for all has been elusive. But now, scientists report in ACS' Journal of Medicinal Chemistry a new vaccine design that could help achieve this goal.

10 Mar 2016

Research could pave way for new generation of anti-cancer drugs

New research has identified a first step in the design of a new generation of anti-cancer drugs that include an agent to inhibit resistance to their effectiveness.

9 Mar 2016

Oversized tonsils and tongue indentations increase risk for OSA

According to a new study led by University at Buffalo orthodontic researcher Thikriat Al-Jewair, dentists are in the unique position as health care professionals to pinpoint signs of obstructive sleep apnea, a disorder in which breathing repeatedly stops and starts during sleep due to blocked upper airways

9 Mar 2016

Surgeon's learning curve linked to fatality rates of oesophageal cancer patients

According to a major Swedish cohort study from researchers at Karolinska Institutet in Sweden and Imperial College London, a surgeon who operates on oesophageal cancer must have performed 60 operations to prevent any lack of experience adversely affecting the long-term survival of the patients. The finding, which is published in the Journal of Clinical Oncology, has potential significance for clinical practice.

9 Mar 2016

Scientists discover brain mechanisms that separate food consumption from cravings

Researchers investigating eating disorders often study chemical and neurological functions in the brain to discover clues to overeating. Understanding non-homeostatic eating -- or eating that is driven more by palatability, habit and food cues -- and how it works in the brain may help neuroscientists determine how to control cravings, maintain healthier weights and promote healthier lifestyles. Scientists at the University of Missouri recently discovered the chemical circuits and mechanisms in the brain that separate food consumption from cravings. Knowing more about these mechanisms could help researchers develop drugs that reduce overeating.

9 Mar 2016