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Sunitinib versus everolimus trial highlights non-clear cell RCC patient response heterogeneity

Sunitinib offers significantly longer progression-free survival than everolimus for patients with metastatic non-clear cell renal cell carcinoma, phase II trial results indicate, but treatment effect appears to depend upon key patient characteristics.

22 Jan 2016

Physiotherapy ‘should be targeted’ in Parkinson’s disease

Physical and occupational therapy does not deliver quality of life benefits for patients with mild to moderate Parkinson’s disease, a randomised trial shows.

22 Jan 2016

Adjuvant Chemotherapy Colon Cancer Trials Should ‘Stratify By MSI, KRAS, BRAF’

A post hoc analysis of the PETACC-8 trial has revealed an interaction between microsatellite instability and BRAF and KRAS mutation status when determining the prognosis of patients with resected stage III colon adenocarcinoma.

22 Jan 2016

BCR–ABL transcript type linked to TKI response, outcomes

The type of BCR–ABL transcript could have an impact on tyrosine kinase inhibitor choice in patients with chronic myeloid leukaemia , according to research published in Blood.

22 Jan 2016

Audiologists investigating impact of remote care on cochlear implant users

Audiologists from the University of Southampton are investigating how a new patient-centred approach can help cochlear implant users manage their own care programme.

22 Jan 2016

UAB study shows IL-37 protein suppresses inflammatory response after spinal cord injury

Spinal cord injuries cause severe functional disabilities in those who sustain them, including paraplegia or tetraplegia, depending on the scale of the injury. This is due to the degeneration of the spinal pathways that carry nerve signals from the brain to the different parts of the body and vice versa, resulting in loss of mobility and sensitivity underneath the injured area.

22 Jan 2016

Oestrogen supplements could reduce dementia risk in women

Women who take oestrogen supplements from before or at the start of menopause and continue with them for a few years have better preserved brain structure, which may reduce the risk of dementia.

22 Jan 2016

Biomedical innovation in the UK: an interview with Zahid Latif

The biomedical research base is one of the UK's strengths; over 1500 companies in the Pharmaceuticals and biotechnology area are established in the UK employing over 70,000.

22 Jan 2016

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

The health of blood cells' energy-producing mitochondria may predict a person's risk of developing chronic kidney disease (CKD), according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

22 Jan 2016

PGD model could provide policy guideposts for human genome editing

Human genome editing for both research and therapy is progressing, raising ethical questions among scientists around the world.

22 Jan 2016

Sensitive computational method could help reveal effect of the immune system on cancer

A study by researchers at Norris Cotton Cancer Center has shown that a very sensitive computational method can be used to reveal the human immune system's effect on cancer. The Dartmouth study was the first to perform an in-depth computational examination of how immune activity translates to prognosis in breast cancer.

22 Jan 2016

Study throws light on why gout not well managed in many patients

A study published online this month in the Arthritis Care and Research journal is shedding light on why gout, a painful and common form of arthritis, is not well managed in many patients. The journal is published by the American College of Rheumatology.

22 Jan 2016

Beta- and gamma-HPVs associated with development of head and neck cancers, finds Einstein study

Researchers at Albert Einstein College of Medicine have found that when human papillomavirus (HPV)-16 is detected in peoples' mouths, they are 22 times more likely than those without HPV-16 to develop a type of head and neck cancer.

22 Jan 2016

Mortality risk higher in people with eating disorders

Results from a newly published study indicate that individuals with eating disorders are at increased risk of death compared to the general population. Investigators found that individuals with anorexia nervosa (AN) had a five times higher mortality rate than their same age peers.

22 Jan 2016

Researchers explore ways to use light to combat cancer

Immunotherapy is one of the hottest emerging areas of cancer research. After all, using the body's own cells to fight cancer can be more effective and less invasive than flooding the entire system with toxic chemicals.

22 Jan 2016

Colon cancer patients lacking CDX2 protein more likely to benefit from chemotherapy

Using a new computer science approach, researchers at University of California, San Diego School of Medicine, Columbia University and Stanford University discovered a distinctive molecular feature — a biomarker — that identified colon cancer patients who were most likely to remain disease-free up to five years after surgery.

22 Jan 2016

Higher-order thalamus enhances and temporarily stores sensory signals

Every day, we constantly absorb information through our sensory organs, which the brain then needs to process correctly. The information initially reaches the main relay center, the thalamus, and then travels to the cerebral cortex.

22 Jan 2016

CU Cancer Center study finds distinct genetic drivers of colorectal cancer in younger and older patients

A University of Colorado Cancer Center study being presented Saturday at the 2016 Genitourinary Cancers Symposium shows genetic differences between colorectal cancer (CRC) in young and old patients, possibly pointing toward different treatments and strategies in combating the young form of the disease.

22 Jan 2016

Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

A new study by a team of Rosalind Franklin University researchers headed by Carl White, PhD, assistant professor of physiology and biophysics, has discovered that the degree of chronic inflammation caused by obesity is highly dependent on levels of the signaling molecule, hydrogen sulfide, which alters the activity of a calcium channel, Orai3.

22 Jan 2016

Researchers use ASC secreted factors to create therapeutic factor concentrate for critical limb ischemia

"Critical limb ischemia" (CLI) describes an advanced stage of peripheral artery disease characterized by obstruction of the arteries and a markedly reduced blood flow to the extremities. CLI identifies patients at high-risk for major amputation. The estimated annual incidence of CLI ranges between 500 and 1000 new cases out of one million people per year, with the highest rates among the elderly, smokers, and those with diabetes. CLI is considered to be a critical public health issue. Attempts at revascularization are often unsuccessful.

22 Jan 2016

Medical Research News

Sunitinib versus everolimus trial highlights non-clear cell RCC patient response heterogeneity

Physiotherapy ‘should be targeted’ in Parkinson’s disease

Adjuvant Chemotherapy Colon Cancer Trials Should ‘Stratify By MSI, KRAS, BRAF’

BCR–ABL transcript type linked to TKI response, outcomes

Audiologists investigating impact of remote care on cochlear implant users

UAB study shows IL-37 protein suppresses inflammatory response after spinal cord injury

Oestrogen supplements could reduce dementia risk in women

Biomedical innovation in the UK: an interview with Zahid Latif

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

PGD model could provide policy guideposts for human genome editing

Sensitive computational method could help reveal effect of the immune system on cancer

Study throws light on why gout not well managed in many patients

Beta- and gamma-HPVs associated with development of head and neck cancers, finds Einstein study

Mortality risk higher in people with eating disorders

Researchers explore ways to use light to combat cancer

Colon cancer patients lacking CDX2 protein more likely to benefit from chemotherapy

Higher-order thalamus enhances and temporarily stores sensory signals

CU Cancer Center study finds distinct genetic drivers of colorectal cancer in younger and older patients

Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

Researchers use ASC secreted factors to create therapeutic factor concentrate for critical limb ischemia

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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