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Researchers reveal secondary structure of Lewy bodies in the brain of Parkinson's disease patients

Lewy bodies had been considered to be a key element of pathogenesis for Parkinson's disease. Although structural analysis for Lewy bodies with an electron microscope had been performed, it had no secondary structural information of proteins, which is important for the development of drugs.

13 Jan 2016

Middle-aged patients undergoing AVR may fare better with tissue-based valves rather than metal-based valves

Patients between the ages of 40 and 70 who undergo aortic valve replacement (AVR) may fare better with tissue-based valves rather than metal-based valves, according to a review article posted online today by The Annals of Thoracic Surgery.

13 Jan 2016

Inflammation associated with elevated glutamate in the brain could guide depression treatments

Psychiatrists investigating depression have been energized in recent years by reports of rapid, successful treatment with drugs that interfere with the brain chemical glutamate, such as the anesthetic ketamine.

13 Jan 2016

CGP3466B compound may effectively treat depression

The compound CGP3466B, already proven nontoxic for people, may effectively and rapidly treat depression, according to results of a study in mice.

13 Jan 2016

Treatment for oesophageal cancer, Barrett’s oesophagus varies significantly across England

New figures released today show that the treatment received by patients for oesophageal cancer, and its precursor condition Barrett’s oesophagus, varies significantly across England.

13 Jan 2016

Racial disparity in 'previable' preterm births linked to infant mortality problem

Black women are nearly four times more likely than white women to have a baby born between 16 and 22 weeks gestation, a time period in which the life of a baby outside the womb is not viable.

13 Jan 2016

Switching to smaller plates could help curb obesity

There are small easy steps that we can take to tackle the burgeoning problem of obesity. One of those solutions is surprisingly simple: use smaller plates.

13 Jan 2016

Cornell researchers identify potent cancer-killing proteins that can kill tumors in bloodstream

Cornell researchers have discovered potent cancer-killing proteins that can travel by white blood cells to kill tumors in the bloodstream of mice with metastatic prostate cancer. The breakthrough study will be published Feb. 10 as the cover article in the Journal of Controlled Release.

13 Jan 2016

CPMC study discovers six genes that affect sleep duration

The Coriell Personalized Medicine Collaborative, a research initiative exploring the utility of genetic information in the clinical setting, has published a study and identified six noteworthy genes that affect human sleep duration.

13 Jan 2016

Sedentary behavior associated with poor cardiovascular health, diabetes in people with severe obesity

Sedentary behavior is associated with poor cardiovascular health and diabetes in adults with severe obesity, independent of how much exercise they perform, a University of Pittsburgh Graduate School of Public Health-led study showed for the first time.

13 Jan 2016

New gene-filtering tool aims to predict disease-causing mutations

Despite their bad reputations, the vast majority of mutations are not harmful. Even in very rare genetic disorders, only one or two genetic variations — out of tens of thousands — is actually the cause of disease. Distinguishing between harmful and harmless mutations has long been a challenge.

13 Jan 2016

High doses of vitamin D may increase risk of falls

According to new research summarized by California Pacific Medical Center Research Institute senior scientist Steven Cummings, MD, and colleagues at the University of California, San Francisco and Harvard Medical School, contrary to common beliefs, relatively high doses of vitamin D may increase the risk of falls.

13 Jan 2016

New mechanism of differentiation may offer novel therapeutic approaches to blood malignancies, solid tumors

In humans the differentiation of stem cells into hundreds of specialized cell types is vital. Differentiation drives development from fertilized egg to a newborn, and it underlies the continuous replacement of the 5 billion cells that die every hour in an adult. On the downside, mutations in differentiation pathways of different cell types can be drivers of cancers.

13 Jan 2016

Minority and ethnic groups diagnosed with colorectal cancer at younger ages

Colorectal cancer is the third most common form of cancer and the second most common cause of cancer deaths in the United States. The chance of developing colorectal cancer increases with age. Now, a study by University of Missouri School of Medicine researchers shows that minority and ethnic groups are being diagnosed with colorectal cancer at younger ages and more advanced stages than non-Hispanic whites.

12 Jan 2016

Young children in deep poverty fare worse on health and development indicators

Young children in deep poverty, whose family income is below 50 percent of the federal poverty line, fare even worse on health and development indicators than children in poverty, according to a study released by the National Center for Children in Poverty at Columbia University's Mailman School of Public Health.

12 Jan 2016

Pre-existing nutritional deficits, immune dysfunction may increase hepatitis E risk during pregnancy

Researchers from the Johns Hopkins Bloomberg School of Public Health have found a link between pre-existing nutritional deficits and immune dysfunction and the risk of hepatitis E infection during pregnancy.

12 Jan 2016

Researchers discover molecular target for DNA repair defects behind Fanconi anemia

Researchers have identified a molecular target and experimental treatment strategy for DNA repair defects behind Fanconi anemia – a complex genetic disorder responsible for birth anomalies, organ damage, anemia and cancer.

12 Jan 2016

Study examines impact of sit-stand workstations in reducing chronic low back pain in office workers

Low back pain is one of the most common causes of job-related disabilities, influencing employee productivity and ultimately significantly impacting the economic well-being of a business. A pilot study by researchers at the Stanford University School of Medicine examined whether access to the sit-stand workstations could help reduce or relieve chronic low back pain in office workers.

12 Jan 2016

IMB scientists identify two proteins vital for demethylation of DNA

Scientists at the Institute of Molecular Biology in Mainz have identified a missing piece of the puzzle in understanding how epigenetic marks are removed from DNA. The research on DNA demethylation sheds new light on a fundamental process that is important in development and diseases such as cancer.

12 Jan 2016

Scientists identify unusual regulator of body weight, metabolic syndrome

Scientists at the Gladstone Institutes have discovered an unusual regulator of body weight and the metabolic syndrome: a molecular mechanism more commonly associated with brain cells. Lowering levels of P75 neurotrophin receptor (NTR)--a receptor involved in neuron growth and survival--protected mice fed a high-fat diet from developing obesity, diabetes, and fatty liver disease.

12 Jan 2016

Medical Research News

Researchers reveal secondary structure of Lewy bodies in the brain of Parkinson's disease patients

Middle-aged patients undergoing AVR may fare better with tissue-based valves rather than metal-based valves

Inflammation associated with elevated glutamate in the brain could guide depression treatments

CGP3466B compound may effectively treat depression

Treatment for oesophageal cancer, Barrett’s oesophagus varies significantly across England

Racial disparity in 'previable' preterm births linked to infant mortality problem

Switching to smaller plates could help curb obesity

Cornell researchers identify potent cancer-killing proteins that can kill tumors in bloodstream

CPMC study discovers six genes that affect sleep duration

Sedentary behavior associated with poor cardiovascular health, diabetes in people with severe obesity

New gene-filtering tool aims to predict disease-causing mutations

High doses of vitamin D may increase risk of falls

New mechanism of differentiation may offer novel therapeutic approaches to blood malignancies, solid tumors

Minority and ethnic groups diagnosed with colorectal cancer at younger ages

Young children in deep poverty fare worse on health and development indicators

Pre-existing nutritional deficits, immune dysfunction may increase hepatitis E risk during pregnancy

Researchers discover molecular target for DNA repair defects behind Fanconi anemia

Study examines impact of sit-stand workstations in reducing chronic low back pain in office workers

IMB scientists identify two proteins vital for demethylation of DNA

Scientists identify unusual regulator of body weight, metabolic syndrome

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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