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Study examines link between use of diabetes drug pioglitazone and increased risk of bladder cancer

Although some previous studies have suggested an increased risk of bladder cancer with use of the diabetes drug pioglitazone, analyses that included nearly 200,000 patients found no statistically significant increased risk, however a small increased risk could not be excluded, according to a study in the July 21 issue of JAMA.

22 Jul 2015

Use of dicloxacillin linked to INR decrease in patients taking vitamin K antagonists

Researchers have found an association between treatment with the antibiotic dicloxacillin and a decrease in international normalized ratio (INR; a measure of blood coagulation) levels among patients taking the vitamin K antagonists warfarin or phenprocoumon, according to a study in the July 21 issue of JAMA.

22 Jul 2015

AS03 and MF59 adjuvants increase immune responses to two doses of H7N9 influenza vaccine

In a phase 2 trial that included nearly 1,000 adults, the AS03 and MF59 adjuvants (a component that improves immune response of inactivated influenza vaccines) increased the immune responses to two doses of an inactivated H7N9 influenza vaccine, with AS03-adjuvanted formulations inducing the highest amount of antibody response, according to a study in the July 21 issue of JAMA.

22 Jul 2015

Study identifies new culprit in Alzheimer's disease development

A recent study conducted at Nathan S. Kline Institute for Psychiatric Research and NYU Langone Medical Center implicates a new culprit in Alzheimer's disease development. The research reveals that ßCTF -- the precursor of the amyloid beta (Aß) peptide -- acts at the earliest stage of Alzheimer's to initiate a range of abnormalities leading to the loss of groups of neurons critical for memory formation.

22 Jul 2015

New TripAdvisor-style website launched to help researchers choose better tools for biomedical research

An international panel of leading scientists is launching a new TripAdvisor-style website aimed at helping researchers choose better-quality research tools - and avoiding potentially serious errors in biomedical research.

22 Jul 2015

Study: Cash to stay in school did not reduce HIV risk among young women in South Africa

A Phase III, individually randomized trial has found conditional cash transfers for school attendance did not reduce the risk of HIV among high-school aged women in South Africa, investigators from the HIV Prevention Trials Network (HPTN) reported today at the 8th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention in Vancouver, Canada.

22 Jul 2015

New model helps to answer longstanding question in cancer science

A paper published today in the Proceedings of the National Academy of Sciences argues against the commonly held "accumulation of mutations" model of oncogenesis in favor of a model that depends on evolutionary pressures acting on populations of cells.

22 Jul 2015

Researchers design virtual IPE curriculum for students in medical and nursing schools

The Institute of Medicine has identified interprofessional education (IPE) as a key innovation for achieving the triple aim of better care, better outcomes and reduced health care costs. Yet, a shortage of qualified faculty and difficulty with aligning learners' schedules often prevent sustainable and scalable IPE.

22 Jul 2015

Dartmouth researchers perform first total syntheses of compounds involved in rapid cell death in leukemia

Dartmouth researchers and their colleagues have carried out the first total syntheses of certain compounds involved in excessive cell death in leukemia.

22 Jul 2015

Dietary phosphate appears to cause spikes in blood phosphorus levels

Phosphates artificially added to dairy and cereal products appear to cause bigger spikes in blood phosphorus levels than naturally occurring phosphates, potentially putting harmful stress on kidneys. Too much dietary phosphate stiffens blood vessels, enlarges the heart and is bad for bones, but a new study by Houston Methodist researchers suggests it matters where the phosphates come from.

22 Jul 2015

Common environmental chemicals may act separately or together to increase risk of cancer

Common environmental chemicals assumed to be safe at low doses may act separately or together to disrupt human tissues in ways that eventually lead to cancer, according to a task force of nearly 200 scientists from 28 countries, including one from Oregon State University.

22 Jul 2015

New CHLA study uncovers baseline characteristics of transyouth seeking care for gender dysphoria

Johanna Olson, MD, and her colleagues at Children's Hospital Los Angeles, provide care for the largest number of transyouth in the U.S. and have enrolled 101 patients in a study to determine the safety and efficacy of treatment that helps patients bring their bodies into closer alignment with their gender of identity.

22 Jul 2015

HOPE VI community revitalization project motivates exercise in Birmingham, Ala., neighborhood

When the HOPE VI community revitalization project in the disadvantaged Birmingham, Ala., neighborhood of Ensley reached the phase of building walking and biking paths, green spaces, and improved lighting in 2010, two things happened, according to a new study: First, residents developed specific expectations that leisure exercise would become more plausible, and then they followed through and got out there.

22 Jul 2015

Elderberry supplement can provide protection from cold, flu-like symptoms following long-haul flights

The negative health effects of international air travel are well documented but now it seems that the common elderberry can provide some relief.

22 Jul 2015

Researchers devise way to induce protective immunity in mice against influenza viruses

A vaccine that protects against a wide variety of influenza viruses (a so-called universal flu vaccine) is a critical public health goal given the significant rates of illness and death caused by seasonal influenza and the potentially devastating effects of a pandemic influenza strain.

22 Jul 2015

Aging may trigger adaptive response to offset effects of oxidative stress on blood vessels

Although the causes of many age-related diseases remain unknown, oxidative stress is thought to be the main culprit. Oxidative stress has been linked to cardiovascular and neurodegenerative diseases including diabetes, hypertension and age-related cancers. However, researchers at the University of Missouri recently found that aging actually offered significant protection against oxidative stress.

22 Jul 2015

Men gain weight after they become dads, new Northwestern Medicine study finds

All those leftover pizza crusts you snatch from your kids' plates add up. Men gain weight after they become fathers for the first time whether or not they live with their children, reports a large, new Northwestern Medicine study that tracked the weight of more than 10,000 men from adolescence to young adulthood.

22 Jul 2015

Study reveals potential new therapeutic target for depression treatment

Increasing the levels of a signaling molecule found in the brain can positively alter response to stress, revealing a potential new therapeutic target for treatment of depression, UT Southwestern Medical Center researchers said.

22 Jul 2015

New study suggests novel ways to treat serous retinal detachment

Wet age-related macular degeneration (AMD) is the leading cause of severe vision loss in older individuals. AMD and other serious chronic eye problems that affect younger individuals result when fluid accumulates abnormally under or within the retina. A new study published in The American Journal of Pathology shows for the first time that the release of substances from mast cells may be a causal factor in this type of eye pathology, and inhibitors of this release may offer new ways to treat serous retinal detachment.

22 Jul 2015

Alzheimer's Association recognizes Li Gan with Inge Grundke-Iqbal Award for Alzheimer's Research

The Alzheimer's Association is recognizing Li Gan, Ph.D., for publishing influential research on the biology of Alzheimer's disease with the Inge Grundke-Iqbal Award for Alzheimer's Research. The Award was presented today during a plenary session at the Alzheimer's Association International Conference 2015 in Washington, D.C.

22 Jul 2015

Medical Research News

Study examines link between use of diabetes drug pioglitazone and increased risk of bladder cancer

Use of dicloxacillin linked to INR decrease in patients taking vitamin K antagonists

AS03 and MF59 adjuvants increase immune responses to two doses of H7N9 influenza vaccine

Study identifies new culprit in Alzheimer's disease development

New TripAdvisor-style website launched to help researchers choose better tools for biomedical research

Study: Cash to stay in school did not reduce HIV risk among young women in South Africa

New model helps to answer longstanding question in cancer science

Researchers design virtual IPE curriculum for students in medical and nursing schools

Dartmouth researchers perform first total syntheses of compounds involved in rapid cell death in leukemia

Dietary phosphate appears to cause spikes in blood phosphorus levels

Common environmental chemicals may act separately or together to increase risk of cancer

New CHLA study uncovers baseline characteristics of transyouth seeking care for gender dysphoria

HOPE VI community revitalization project motivates exercise in Birmingham, Ala., neighborhood

Elderberry supplement can provide protection from cold, flu-like symptoms following long-haul flights

Researchers devise way to induce protective immunity in mice against influenza viruses

Aging may trigger adaptive response to offset effects of oxidative stress on blood vessels

Men gain weight after they become dads, new Northwestern Medicine study finds

Study reveals potential new therapeutic target for depression treatment

New study suggests novel ways to treat serous retinal detachment

Alzheimer's Association recognizes Li Gan with Inge Grundke-Iqbal Award for Alzheimer's Research

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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