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Diabetes with coronary disease: A moving target amid evolving therapies

In an editorial in the current issue of the New England Journal of Medicine (NEJM), William E. Boden, M.D., professor of medicine and preventive medicine at the University at Buffalo, recommends that the results of the BARI-2D Trial published in that edition must be interpreted with "considerable caution."

8 Jun 2009

Research shows how cells tell time

In a new study appearing online this week in the Proceedings of the National Academy of Sciences, Dr. Liu and his co-workers have found that this mold, which uses a protein called FRQ as the main gear of its clock, marks time by a sequence of changes in the protein's chemical structure.

8 Jun 2009

Discovery 'significant step' in understanding leukaemia drug resistance

Scientists have pinpointed an enzyme responsible for breaking down and inactivating a key childhood leukaemia drug, which could help to explain why around 20 per cent of patients do not respond to therapy. Their findings are published in the Journal of Clinical Investigation.

8 Jun 2009

Johnson & Johnson's research reflecting new Washington policies

Health care supplier Johnson & Johnson will focus on new treatments and improved tests for cancer and other diseases for which company perceives unmet needs, like diabetes, hepatitis C, and HIV, as well as using new, Washington-supported research techniques to gauge their effectiveness, researchers and executives said at a briefing with analysts, BusinessWeek reports.

5 Jun 2009

Fatigue common after heart attack

Half of all patients who undergo myocardial infarction (heart attack) are experiencing onerous fatigue four months after the infarction. The patients who are most fatigued are those who perceive the infarction as a sign of chronic illness, those who experience the illness as difficult to control, and those who believe that the illness has a large impact on their life. These are the conclusions of a thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden.

5 Jun 2009

Alcohol and smoking the culprits in bowel cancer

Each year, worldwide around one million new cases of bowel (colorectal) cancer are diagnosed and more than half a million people die from the disease.

4 Jun 2009

Keep Grandad away from the pokies!

According to Australian researchers easier access to gambling venues has influenced the rise in the number of older adults with gambling problems but there is more to the issue.

4 Jun 2009

Drug derived from the hydrangea root shows promise for autoimmune disorders

A drug derived from the hydrangea root, used for centuries in traditional Chinese medicine, shows promise in treating autoimmune disorders, report researchers from the Program in Cellular and Molecular Medicine and the Immune Disease Institute at Children's Hospital Boston (PCMM/IDI), along with the Harvard School of Dental Medicine.

4 Jun 2009

Cigarette smoking does not affect everyone in same way

Cigarette smoking induced COPD, or chronic obstructive pulmonary disease, is a disease that results in severe breathing difficulty. According to World Health Organization (WHO) it is the fourth leading killer worldwide. However the mechanisms responsible for some smokers developing COPD and others evading the disease have not been well understood.

4 Jun 2009

Cancer vaccine efficacy enhanced using anti-diabetic drug Metformin

After a vaccination or an infection, the human immune system remembers to keep protecting against invaders it has already encountered, with the aid of specialized B-cells and T-cells. Immunological memory has long been the subject of intense study, but the underlying cellular mechanisms regulating the generation and persistence of long-lived memory T cells remain largely undefined. Now, University of Pennsylvania School of Medicine researchers have found that a common anti-diabetic drug might enhance the effectiveness of vaccines. The findings are described this week in an advanced online publication of Nature.

4 Jun 2009

Australian researchers advance bowel cancer detection

Australian researchers have developed gene expression biomarkers which can accurately discriminate pre-cancerous and cancerous colorectal growths from non-cancerous controls.

4 Jun 2009

Study gives clues to how ultra-rare adrenocortical cancer forms

At the ends of chromosome are special pieces of DNA called telomeres. Think of it as the little tip that caps off a shoelace. The telomeres send signals to the cells to let them know it's the end point, not a break that should be repaired.

4 Jun 2009

Discovery of critical marker of response to gemcitabine in pancreatic cancer

A protein related to aggressive cancers can actually improve the efficacy of gemcitabine at treating pancreatic cancer, according to a Priority Report in Cancer Research, published by researchers at Thomas Jefferson University.

4 Jun 2009

Discovery of two proteins may lead to more effective treatment of endocarditis and infections associated with implants

A research team at the Faculty of Odontology at Malmö University in Sweden has discovered two new proteins that are of importance to the survival of bacteria and their colonization of the human body. Besides enhancing our knowledge of the ability of bacteria to spread, the findings may also lead to more effective treatment of endocarditis and infections associated with implants.

4 Jun 2009

Report says 650,000 cancer deaths avoided between 1990 and 2005

The American Cancer Society's annual cancer statistics report finds that 15 years of steady declines in overall cancer death rates translate to about 650,000 deaths from cancer avoided or delayed during that time period. The estimate comes from 'Cancer Statistics 2009,' published early online and appearing in the July/August print issue of CA: A Cancer Journal for Clinicians.

4 Jun 2009

Stopping fatty change in heart cells

Heart failure is one of the world's most frequent causes of death - caused by conditions such as diabetes and obesity. With people who are overweight, the heart has to do more work in order to pump the blood through the circulatory system and this causes an increase in blood pressure.

4 Jun 2009

Importance of preventing vascular congestion in heart failure

Preventing vascular congestion is an important mediator in heart failure, reports a study in the June issue of the Journal of Cardiac Failure, published by Elsevier.

4 Jun 2009

Comprehensive review on sulfonylureas in the latest issue of Diabetic Hypoglycemia

The latest issue of the online journal Diabetic Hypoglycemia features an authoritative review on sulfonylureas by Professor Ian Campbell, a leading expert in oral hypoglycemia therapy.

4 Jun 2009

Research investigates the treatment of traumatic brain and head injury

The National Institute for Health Research Health Technology Assessment (NIHR HTA) programme is expanding the evidence base surrounding the treatment of traumatic brain and head injury (TBI) by commissioning four new research projects. If left untreated many patients with head injury will rapidly develop complications which may lead to death or permanent disability. More than 100,000 people in the UK have long-term effects caused by such injuries. Prompt medical treatment may prevent the worsening of symptoms and lead to a better outcome.

4 Jun 2009

Discovery of protein that helps determine progression of idiopathic pulmonary fibrosis

Researchers say the protein - Serum surfactant protein A - is superior to other IPF predictors and could lead to better decisions about treatment and timing of lung transplantation.

4 Jun 2009