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Early targeted muscle reinnervation cuts chronic pain after amputation

Performed early – at the time of amputation – a procedure called targeted muscle reinnervation (TMR) can reduce pain scores and prevent complications related to abnormal nerve regrowth, suggests a study in the January issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.

4 Jan 2024

Anti-CTLA-4 nanobodies offer promising strategy to prevent colitis in cancer immunotherapy

Microbiota-reactive T cells trigger colitis in mice harboring the microbiota of wild-caught mice following CTLA-4 blockade, according to a new study that reveals a major mechanism by which anti-CTLA-4 antibodies induce inflammatory toxicities during antitumor immune checkpoint inhibitor therapies.

4 Jan 2024

Is screen time really to blame for poor drawing skills in kids?

Study found that the link between screen viewing and drawing ability in young French children is influenced by socioeconomic factors, rather than a direct causal relationship between screen time and cognitive development.

4 Jan 2024

Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

An international collaborative study led by postdoctoral scientist, Dr. Maimuna Paul, and child neurologist, Dr. Hsiao-Tuan Chao, an assistant professor at Baylor College, a faculty member with the Cain Pediatric Neurology Research Foundation Laboratories at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, and an investigator at the McNair Medical Institute with The Robert and Janice McNair Foundation, recently discovered that variants in the PPFIA3 gene cause a previously unknown syndromic neurodevelopmental disorder.

4 Jan 2024

USC scientists develop first all-human brain organoids model of the cerebellum with functional neurons

In a first for USC Stem Cell scientists, the laboratory of Giorgia Quadrato, an assistant professor of stem cell biology and regenerative medicine, has pioneered a novel human brain organoid model that generates all the major cell types of the cerebellum, a hindbrain region predominantly made up of two cell types necessary for movement, cognition, and emotion: granule cells and Purkinje neurons.

4 Jan 2024

40-year timeline of HIV: Testing assays, global burden, prevalence, treatment, and challenges

Announcing a new article publication for Zoonoses journal. More than 77 million individuals have been infected with the human immunodeficiency virus (HIV) and approximately 37.6 million people are living with HIV infection.

4 Jan 2024

Sample type and time of collection play a role in the diagnosis of scrub typhus

Announcing a new article publication for Zoonoses journal. Scrub typhus (ST) is an acute febrile illness caused by Orientia tsutsugamushi. Laboratory tests are needed to confirm the diagnosis when the characteristic eschar is absent.

4 Jan 2024

Early pandemic sees drop in child UTI diagnoses, severity unchanged

A cohort study in JAMA Network Open found a decrease in urinary tract infection (UTI) diagnoses among children during the early COVID-19 pandemic without an increase in disease severity, suggesting a potential reduction in over- or misdiagnosis.

4 Jan 2024

Scientists unearth dual-action weapons against deadly tuberculosis

A research team has detected various substances that have a dual effect against tuberculosis: They make the bacteria causing the disease less pathogenic for human immune cells and boost the activity of conventional antibiotics / publication in ‘Cell Chemical Biology’.

4 Jan 2024

New study highlights the work of biobank at the Colorado Center for Personalized Medicine

A new peer-reviewed study in the American Journal of Human Genetics highlights the work of the biobank at the Colorado Center for Personalized Medicine (CCPM), a world-class site for precision medicine in research and clinical care created in partnership with the University of Colorado Anschutz Medical Campus and UCHealth.

4 Jan 2024

Novel population health tool for predicting ICU survivorship and mortality in older adults

A significant obstacle to improving care and outcomes for intensive care unit (ICU) patients is the unexpected nature of becoming seriously ill.

4 Jan 2024

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

A detailed 'atlas' of neuroblastoma tumors points to a new target for immunotherapy. Scientists from the Princess Máxima Center for Pediatric Oncology in the Netherlands mapped this childhood tumor at the level of individual cancer and immune cells.

4 Jan 2024

Gonorrhea cases surge 64% post-COVID lockdown in England, highlighting unintended STI suppression

A study analyzing data from the Genitourinary Medicine Clinic Activity Dataset in England shows a 64% increase in gonorrhea diagnoses following the relaxation of COVID-19 restrictions, despite only a 5.6% increase in STI testing, suggesting that social distancing may have suppressed STI transmission.

4 Jan 2024

Metabolically armored CAR-T cells demonstrate lasting efficacy against solid tumors

At EPFL's School of Engineering, Professor Li Tang's Laboratory of Biomaterials for Immunoengineering has made significant strides in cancer treatment research.

4 Jan 2024

Pre-pregnancy stress raises blood sugar during pregnancy, study finds

A new Journal of the Endocrine Society study among women attending a fertility center found that those with more stress before pregnancy had higher blood sugar levels during pregnancy, which is a sign of weaker cardiovascular health.

4 Jan 2024

HPV infection linked to doubled risk of thyroid cancer

A study in Taiwan involving 3,062 thyroid cancer patients and 9,186 controls finds that HPV infection more than doubles the risk of developing thyroid cancer, providing the first evidence of a carcinogen for this common endocrine cancer.

4 Jan 2024

Study unveils novel method for visualizing muscle coordination and assessing fatigue

Surface electromyography (sEMG) is a traditional method used to measure the electrical activity of muscles during physical activity.

4 Jan 2024

Prevention of post-menopausal osteoporosis in rats by sesame oil

Study demonstrates that daily supplementation with sesame oil in a rat model effectively prevents post-menopausal osteoporosis by maintaining serum estrogen and aromatase levels, suggesting its potential as a safer alternative to hormone replacement therapy.

4 Jan 2024

Computerized cognitive training shows promise in enhancing memory for dementia patients

Study systematically reviews and meta-analyzes the impact of computerized cognitive training (CCT) on memory functions in patients with mild cognitive impairment or dementia, highlighting the benefits of both supervised and unsupervised CCT.

4 Jan 2024

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications.

4 Jan 2024

Medical Research News

Early targeted muscle reinnervation cuts chronic pain after amputation

Anti-CTLA-4 nanobodies offer promising strategy to prevent colitis in cancer immunotherapy

Is screen time really to blame for poor drawing skills in kids?

Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

USC scientists develop first all-human brain organoids model of the cerebellum with functional neurons

40-year timeline of HIV: Testing assays, global burden, prevalence, treatment, and challenges

Sample type and time of collection play a role in the diagnosis of scrub typhus

Early pandemic sees drop in child UTI diagnoses, severity unchanged

Scientists unearth dual-action weapons against deadly tuberculosis

New study highlights the work of biobank at the Colorado Center for Personalized Medicine

Novel population health tool for predicting ICU survivorship and mortality in older adults

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

Gonorrhea cases surge 64% post-COVID lockdown in England, highlighting unintended STI suppression

Metabolically armored CAR-T cells demonstrate lasting efficacy against solid tumors

Pre-pregnancy stress raises blood sugar during pregnancy, study finds

HPV infection linked to doubled risk of thyroid cancer

Study unveils novel method for visualizing muscle coordination and assessing fatigue

Prevention of post-menopausal osteoporosis in rats by sesame oil

Computerized cognitive training shows promise in enhancing memory for dementia patients

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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