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Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

Blood test shows promise to identify Alzheimer's changes in the brain before symptom onset

The University of Kentucky's Sanders-Brown Center on Aging has been around for nearly half a century. In that time, they have built an international reputation for best-in-class research into a disease that kills more people every year than breast and prostate cancer combined – Alzheimer's disease.

10 Mar 2022

Most cancer patients develop antibodies after receiving COVID-19 vaccine, study shows

Cancer patients who have compromised immune systems due to their disease or therapy remain at high risk for COVID-19 infection.

10 Mar 2022

Researchers identify motor neuron toxin associated with ALS

An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) contributes to the motor neuron death that is the signature of these diseases.

10 Mar 2022

Alzheimer’s disease protein helps skin cancer cells thrive when they metastasize to the brain

Amyloid beta, a protein known to build up in the brains of people with Alzheimer's disease, also helps skin cancer cells thrive when they spread to the brain, a new study finds.

10 Mar 2022

Long-lasting immune activity in the airways may be the cause of persistent post-COVID-19 breathlessness

Long-lasting immune activity in the airways might be the cause of persistent breathlessness following COVID-19.

10 Mar 2022

Tannic acid plays a role in inhibiting three key molecular pathways involved in SARS-CoV-2 infection

Professor Charles Ramassamy and his postdoctoral researcher Mohamed Haddad at Institut national de la recherche scientifique, in collaboration with scientists from Université de Montréal, McGill University, and Université du Québec à Montréal, believe that tannic acid plays a role in inhibiting three important molecular pathways involved in the SARS-CoV-2 infection.

10 Mar 2022

Using metal oxide nanoparticles as 'radiosensitizers' for gentler cancer treatment

Radiation therapy is one of the cornerstones of cancer therapy. However, some types of tumor respond little or hardly at all to radiation. If it were possible to make tumor cells more sensitive, treatment would be more effective and gentler.

10 Mar 2022

Natural SARS-CoV-2 infection-induced anti-spike antibody responses

Researchers demonstrated the anti-spike antibody response to SARS-CoV-2 infection and further estimated the acute SARS-CoV-2 infection-induced Ab activity against recently emerged variants like Omicron.

10 Mar 2022

Origins and evolutions of SARS-CoV-2 Alpha variant in the UK

In a new study, researchers presented the origins and evolution of the SARS-CoV-2 lineage B.1.1.7 in the United Kingdom.

10 Mar 2022

Cross-species infectivity of SARS-CoV-2 variants correlated with prevalence

New research discusses the role of mutations in the receptor-binding domain of the spike protein in the generation of antibody resistance and loss of vaccine efficacy.

10 Mar 2022

Individual-based model describing the transmission and spread of SARS-CoV-2 in the Belgian population

A recent study simulated the superspreading dynamics of COVID-19.

10 Mar 2022

Evaluating the Seven Components of Wisdom

In this interview, we speak to Professor Dilip Jeste about what 'wisdom' actually is, how it can be assessed, and what this can mean for our health.

10 Mar 2022

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Researchers explored strategies to develop an mRNA-based COVID-19 vaccine that could elicit safer and wider protection against SARS-CoV-2 variants of concern.

10 Mar 2022

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

New research describes a novel approach whereby SARS-2 antigens were analyzed for conserved sites that may be targeted by broadly neutralizing antibodies that will confer immunity to other Sarbecoviruses.

10 Mar 2022

Quantification of hydrophobic interactions encoded by FP1 sequences of SARS-CoV-2 and MERS-CoV by single-molecule force measurements

Researchers quantified hydrophobic interactions encoded by fusion peptide 1 sequences of SARS-CoV-2 and MERS-CoV using single-molecule force measurements.

10 Mar 2022

Medical Science News

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Blood test shows promise to identify Alzheimer's changes in the brain before symptom onset

Most cancer patients develop antibodies after receiving COVID-19 vaccine, study shows

Researchers identify motor neuron toxin associated with ALS

Alzheimer’s disease protein helps skin cancer cells thrive when they metastasize to the brain

Long-lasting immune activity in the airways may be the cause of persistent post-COVID-19 breathlessness

Tannic acid plays a role in inhibiting three key molecular pathways involved in SARS-CoV-2 infection

Using metal oxide nanoparticles as 'radiosensitizers' for gentler cancer treatment

Natural SARS-CoV-2 infection-induced anti-spike antibody responses

Origins and evolutions of SARS-CoV-2 Alpha variant in the UK

Cross-species infectivity of SARS-CoV-2 variants correlated with prevalence

Individual-based model describing the transmission and spread of SARS-CoV-2 in the Belgian population

Evaluating the Seven Components of Wisdom

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

Quantification of hydrophobic interactions encoded by FP1 sequences of SARS-CoV-2 and MERS-CoV by single-molecule force measurements

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Association of benzodiazepines with SARS-CoV-2 positivity and clinical outcomes in three patient groups

The trajectory of B-cell immunity six months after mRNA vaccination

Long COVID symptoms in families a year after SARS-CoV-2 infection or household exposure

Advancing Motor Neuron Disease Diagnosis with Non-Invasive Ultrasound and AI

How agentic AI is reshaping laboratory workflows

Fourier 80: bringing benchtop NMR systems to the laboratory

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