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Simple, inexpensive method to predict the risk of functional disability in older people

Researchers at the Federal University of São Carlos in the state of São Paulo, Brazil, in partnership with colleagues at University College London in the UK have discovered an efficient, simple and inexpensive method of predicting the risk of functional disability in older people.

21 Dec 2021

How the SARS-CoV-2 Omicron variant spike protein is changing

The study assesses the degree to which the D614G mutation in the SARS-CoV-2 RBD allows access of spike protein trimers to LA-binding-like conformations.

21 Dec 2021

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

A new study demonstrates significantly altered structure and cellularity of Peyer’s patches in deceased COVID-19 patients.

21 Dec 2021

Diagnostic assays that use the 2019-nCoV-N1 primer-probe are unlikely to be impacted by Omicron variant

A new study aimed to detect the genomic material of SARS-CoV-2 and its variants, such as the recently emerged variant of concern (VOC) Omicron.

21 Dec 2021

Effect of T cell reactivity in COVID-19 infection and vaccination

Researchers recently developed an immunodiagnostic T cell assay to classify T cell immune responses of the subjects based on their coronavirus disease 2019 infection and vaccination history.

21 Dec 2021

Do reactive oxygen species play a role in fighting COVID-19?

Serum-free thiols are known to reflect the activity of reactive oxygen species in the body, and researchers have been examining the difference in these thiols in COVID-19 patients.

21 Dec 2021

Crude infection fatality rate is a key indicator in understanding COVID-19 mortality

Researchers leveraged recent data sources and broadly applicable modeling strategies to calculate the COVID-19 crude infection fatality rate (cIFR) in 77 countries from 28 March 2020 to 31 March 2021

21 Dec 2021

Stabilizing the long-term endemic behavior of COVID-19

Researchers used a classic age and contact structured model to explore the several reopening and vaccination coverage scenarios regarding the COVID-19 pandemic.

21 Dec 2021

Younger cancer patients at particularly increased risk of mortality from COVID-19

Systematic reviews and meta-analysis were conducted to identify the impact of SARS-CoV-2 in cancer patients based on tumor type, age, and treatment, and any novel risk factors for COVID-19 in cancer patients

21 Dec 2021

Understanding SARS-CoV-2-induced systemic amyloidosis

A new study proposed that inflammation combined with aggregates of amyloidogenic peptides of SARS-CoV-2 S proteins might induce systemic amyloidosis.

21 Dec 2021

Insight into COVID-19 brain complications

In this interview, we speak to Professor Scott H. Faro about his latest research that looked into COVID-19 and its complications within the central nervous system.

21 Dec 2021

Study reveals how gut bacteria can impact the course of neurological diseases

A New York-based, multi-institutional research team has found high levels of three toxic metabolites produced by gut bacteria in the cerebrospinal fluid and plasma samples of multiple sclerosis (MS) patients.

21 Dec 2021

Researchers study how brain deficits associated with HIV and cocaine addiction might add up

Researchers with the Del Monte Institute for Neuroscience at the University of Rochester are studying how the brain puts the 'brakes' on behavior. That may be different in individuals recovering from cocaine addiction and who are also HIV-positive.

21 Dec 2021

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Interesting research decrypts a recurring sequence in antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) and identifies it to be a board neutralizing antibody that targets a conserved epitope on the SARS-CoV-2 receptor-binding domain (RBD) of the spike protein.

21 Dec 2021

Risk of hospitalization for infants and children with COVID-19 below 1%

Children are a low-risk group for COVID-19 following infection with SARS-CoV-2, with less than 2% of European hospitalizations with the disease being in children below the age of 19.

21 Dec 2021

Children with isolated symptoms as likely as those with multiple symptoms to test COVID-19 positive

A new study compares rates of coronavirus disease 2019 infection in children who reported no symptoms, one isolated symptom, or two or more symptoms during the circulation of the Delta variant.

21 Dec 2021

Vulnerable children in UK faced a healthcare shortage during the pandemic period

A new preprint describes the pattern seen among children who needed healthcare during the pandemic, demonstrating how the vulnerable had a higher rate of care deficits.

21 Dec 2021

Estimating vaccine efficacy against COVID-like illness from omicron and other COVID-19 variants

A new study combines real-time syndromic surveillance data from daily cross-sectional surveys with a COVID-like illness (CLI) prevalence-based vaccine efficacy estimator to better explain the early onset of the omicron variant.

21 Dec 2021

Booster shots improve CD8+ T cell response to SARS-CoV-2 in animal model

In a new study, published on the bioRxiv* preprint server, scientists showed in a mice model that three doses of the same synthetic peptide vaccine, eliciting an exclusive CD8+ T cell response against one SARS-CoV-2 Spike epitope, protected against lethal SARS-CoV-2 infection, in the absence of neutralizing antibodies. Researchers also showed that the third dose resulted in superior generation of effector-memory T cells in the circulation and tissue-resident memory T (TRM) cells.

20 Dec 2021

Researchers find a digital silver lining in failed COVID-19 drug trial

A clinical trial in which two test drugs failed to help patients with mild COVID-19 nevertheless had a silver lining: It proved the viability of a study model in which a medication's potential arrhythmic side effects are safely, effectively monitored without the participants ever setting foot in a hospital or clinic.

20 Dec 2021

Medical Science News

Simple, inexpensive method to predict the risk of functional disability in older people

How the SARS-CoV-2 Omicron variant spike protein is changing

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

Diagnostic assays that use the 2019-nCoV-N1 primer-probe are unlikely to be impacted by Omicron variant

Effect of T cell reactivity in COVID-19 infection and vaccination

Do reactive oxygen species play a role in fighting COVID-19?

Crude infection fatality rate is a key indicator in understanding COVID-19 mortality

Stabilizing the long-term endemic behavior of COVID-19

Younger cancer patients at particularly increased risk of mortality from COVID-19

Understanding SARS-CoV-2-induced systemic amyloidosis

Insight into COVID-19 brain complications

Study reveals how gut bacteria can impact the course of neurological diseases

Researchers study how brain deficits associated with HIV and cocaine addiction might add up

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Risk of hospitalization for infants and children with COVID-19 below 1%

Children with isolated symptoms as likely as those with multiple symptoms to test COVID-19 positive

Vulnerable children in UK faced a healthcare shortage during the pandemic period

Estimating vaccine efficacy against COVID-like illness from omicron and other COVID-19 variants

Booster shots improve CD8+ T cell response to SARS-CoV-2 in animal model

Researchers find a digital silver lining in failed COVID-19 drug trial

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

Data management challenges in scientific research

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