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Previous SARS-CoV-2 infection associated with more adverse events following mRNA vaccination

The phase 3 trials of the Pfizer and Moderna COVID-19 vaccines did not include those with a known previous SARS-CoV-2 infection. Recent evidence indicates that mRNA vaccines may induce more adverse events in these individuals. In a recent study, 947 individuals, 265 of which have previously reported SARS-CoV-2 infection, were monitored post-vaccination for adverse events, finding that there could be a link between previous infection and greater incidence of these events.

26 Apr 2021

Cleavage site recognition by SARS-CoV-2 main protease as new antiviral drug target

Many research groups have and are investigating main protease inhibitors as antiviral drugs, and in a paper recently uploaded to the bioRxiv* preprint server, a team of researchers examine the crystal structure of the protein while bound to various viral substrate peptides (P1-4). In doing so, they reveal the way in which the bound peptide sequence can direct and modulate enzyme activity, providing new templates towards antiviral drug design.

26 Apr 2021

Researchers examine potential SARS-CoV-2 antivirals using a drug repurposing library

A new study deals with the screening of the Drug Repurposing Hub (DRH) library for identifying small compounds which are capable of inhibiting SARS-CoV-2 using both in vitro and in vivo experimental studies. These molecules could be used for designing a novel therapeutic system against SARS-CoV-2 infection.

26 Apr 2021

Fighting malaria in 2021: Where are we now and where are we going?

In support of World Malaria Day, News-Medical spoke to Dr. Laurence Slutsker, an internationally recognized expert in malaria, about fighting this disease in 2021.

26 Apr 2021

Using estrogen to target drug-resistant breast cancer in mice

Researchers at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center (NCCC) hope to make estrogen therapy a more accessible treatment option for breast cancer patients who could benefit from it.

26 Apr 2021

Researchers harness the body's own ability to block pain

Fentanyl, oxycodone, morphine--these substances are familiar to many as a source of both pain relief and the cause of a painful epidemic of addiction and death.

26 Apr 2021

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Can a high dose of vitamin D administered on admission to hospital improve the condition of patients with moderate or severe COVID-19? The answer is no, according to a Brazilian study published in the Journal of the American Medical Association.

23 Apr 2021

Study sheds light on the ability of CBD to reduce pain

It's been hailed as a wonder drug and it's certainly creating wonder profits. By some estimates, the Cannabidiol (or CBD) market could be worth $20 billion dollars by 2024.

23 Apr 2021

Research could inform therapeutic approaches to ameliorate the effects of fetal immobility

Researchers from Trinity College Dublin have discovered that some skeletal defects associated with a lack of movement in the womb during early development may still be ameliorated after such periods of immobility if movement resumes.

23 Apr 2021

Researchers investigate how philosophical approaches can change the understanding of pain

Dr. Sabrina Coninx from Ruhr-Universität Bochum and Dr. Peter Stilwell from McGill University, Canada, have investigated how philosophical approaches can be used to think in new ways about pain and its management.

23 Apr 2021

Regulatory protein in skeletal muscle fiber may play a key role in the body's fight or flight response

Researchers at the University of Cincinnati say a regulatory protein found in skeletal muscle fiber may play an important role in the body's fight or flight response when encountering stressful situations.

23 Apr 2021

People with a higher Omega-3 Index lived longer than others, study shows

A new research paper examining the relationship between the Omega-3 Index and risk for death from any and all causes has been published in Nature Communications.

23 Apr 2021

Heart brain interactions provide a new diagnostic avenue for patients with disorders of consciousness

A new study conducted jointly by the University of Liege (Belgium) and the Ecole normale superieure - PSL (France) shows that heart brain interactions, measured using electroencephalography (EEG), provide a novel diagnostic avenue for patients with disorders of consciousness.

23 Apr 2021

Macrophages play a vital role in re-establishing and controlling blood flow after tissue damage

Cardiovascular disease, the most common cause of death, is the result of oxygen deprivation as blood perfusion to affected tissue is prevented.

23 Apr 2021

Study reports on safety of COVID-19 mRNA vaccines in pregnancy

Researchers used different surveillance systems in the United States to track adverse outcomes after coronavirus disease 2019 (COVID-19) vaccination in pregnant people and found no major safety flags.

23 Apr 2021

NIH to conduct large trial for COVID-19 polyclonal antibody therapies

The National Institutes of Health (NIH) in the USA are to conduct a large-scale clinical trial to evaluate a new fully-human polyclonal antibody therapy targeted at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19).

23 Apr 2021

Researchers identify cognitive computations underlying the complex predictive behavior

Fast reactions to future events are crucial. A boxer, for example, needs to respond to her opponent in fractions of a second in order to anticipate and block the next attack. Such rapid responses are based on estimates of whether and when events will occur.

23 Apr 2021

Medical Science News

Previous SARS-CoV-2 infection associated with more adverse events following mRNA vaccination

Cleavage site recognition by SARS-CoV-2 main protease as new antiviral drug target

Researchers examine potential SARS-CoV-2 antivirals using a drug repurposing library

Fighting malaria in 2021: Where are we now and where are we going?

Using estrogen to target drug-resistant breast cancer in mice

Researchers harness the body's own ability to block pain

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Study sheds light on the ability of CBD to reduce pain

Research could inform therapeutic approaches to ameliorate the effects of fetal immobility

Researchers investigate how philosophical approaches can change the understanding of pain

Regulatory protein in skeletal muscle fiber may play a key role in the body's fight or flight response

People with a higher Omega-3 Index lived longer than others, study shows

Heart brain interactions provide a new diagnostic avenue for patients with disorders of consciousness

Macrophages play a vital role in re-establishing and controlling blood flow after tissue damage

Study reports on safety of COVID-19 mRNA vaccines in pregnancy

NIH to conduct large trial for COVID-19 polyclonal antibody therapies

Researchers identify cognitive computations underlying the complex predictive behavior

C-Path opens access to D-RSC database to accelerate therapy development for DMD

Clinical trial examines metabolic effects of natural compound NMN in people

Increased use of tourniquets has improved patient survival in Los Angeles County

Advancing Motor Neuron Disease Diagnosis with Non-Invasive Ultrasound and AI

How agentic AI is reshaping laboratory workflows

Fourier 80: bringing benchtop NMR systems to the laboratory

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