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Can limiting the priming dose of a SARS-CoV-2 vaccine improve immunity?

Researchers from Northwestern University and the University of Rochester in the U.S. addressed this question in their study. The researchers also explored whether the vaccines administered across the world could confer sterilizing immunity while preventing severe disease and death.

6 Apr 2021

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

To date, little evidence has been documented regarding the immune responses after the onset of the symptoms or virus detection. Further, no cross-sectional studies have been conducted that define the time of infection. Thereby, no report is available that explains the relationship between the earliest immune responses to COVID-19 and temporal kinetics. New research deals with this research gap using blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing methods.

6 Apr 2021

Study suggests T-cells don't determine survival in severe COVID-19

In the study, which appeared on the pre-print server medRxiv, the team found that when the monkeys were reinfected, the T cell-depleted animals showed anamnestic immune responses, the enhanced reaction of the body's immune system to an antigen that is related to an antigen previously encountered.

6 Apr 2021

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options.

6 Apr 2021

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks

In a methodologically ‘state-of-the-art’ approach, US researchers have developed a protein-based nanoparticle vaccine against coronavirus disease (COVID-19), with a swift generation of antibodies and the potential to protect individuals who cannot receive other COVID-19 vaccines for medical reasons. The research is posted to the bioRxiv* preprint server.

5 Apr 2021

Devastating liver disease itching turns out to have a surprising cause

A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer layer of the skin is so much more than insulation.

5 Apr 2021

Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure

Like a bad water pump that fails to circulate coolant in a car engine, a failing heart struggles to pump blood through the body, causing symptoms of fatigue, shortness of breath, and swelling in the legs and feet.

5 Apr 2021

Different neural circuitries linked to distinct Parkinsonian behavioral deficits

Parkinson's disease (PD) is well known as a debilitating disease that gradually worsens over time. Although the disease's progression has been largely tied to the loss of motor functions, non-motor symptoms, including the loss of cognitive abilities, often emerge early in the disease.

5 Apr 2021

Can universal vaccines and treatments against future SARS-CoV-2 variants be developed?

A team of researchers from Saudi Arabia and Spain recently quantified the rapid evolution of SARS-CoV-2 by tracking the mutations of the virus globally, focusing on the receptor-binding domain (RBD) of the virus’s spike protein, which determines its infectivity.

5 Apr 2021

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

A team of scientists from the USA and Sweden has recently screened 8 million small molecule inhibitors against SARS-CoV-2.

5 Apr 2021

SARS-CoV-2 cryptic transmission modeling shows emergence of first wave in US and Europe

To analyze this cryptic transmission phase and the first wave of the pandemic that ensued, researchers from Italy, UK, and the US used a data-driven, spatial, stochastic, and age-structured epidemic model. They developed a mechanistic understanding of the evolution of the epidemic and estimated the time required for local transmission in various states and countries. The model developed by the team offers a statistical idea of SARS-CoV-2 introductions across European countries and many states in the US.

5 Apr 2021

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the SARS-CoV-2.

5 Apr 2021

RNA-binding cylinders inhibit SARS-CoV-2 replication in vitro

Research led by Michael J. Hannon from the University of Birmingham, UK, finds metallo-supramolecular helicates (cylinders) binding to untranslated regions of SARS-CoV-2 suppresses viral replication. The untranslated regions (UTR) of the viral genome could serve as drug targets for antiviral treatment.

5 Apr 2021

Study paves way for effective monitoring of chemotherapeutic drug level in cancer patients

Cancer is the world's second deadliest disease which contributes towards the fatality of over 10 million people per year.

3 Apr 2021

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule.

3 Apr 2021

Treatment resistance in triple-negative breast cancers linked to softer tissue environment

Researchers at the University of California, San Francisco, have discovered that aggressive, triple-negative breast cancers (TNBCs) can evade treatment by reorganizing and softening the collagen matrix that surrounds the cancer cells.

3 Apr 2021

Study uncovers novel mechanism in rare mutation associated with Alzheimer's

A novel mechanism has been identified that might explain why a rare mutation is associated with familial Alzheimer's disease in a new study by investigators at the University of Chicago.

3 Apr 2021

Combination of tumor cell vaccine and checkpoint therapy creates effective immune response

A personalized tumor cell vaccine strategy targeting Myc oncogenes combined with checkpoint therapy creates an effective immune response that bypasses antigen selection and immune privilege, according to a pre-clinical study for neuroblastoma and melanoma.

3 Apr 2021

Research provides insights on why redheads exhibit altered sensitivity to pain

New research led by investigators at Massachusetts General Hospital provides insights on why people with red hair exhibit altered sensitivity to certain kinds of pain. The findings are published in Science Advances.

2 Apr 2021

Higher B.1.1.7 transmission in households than other SARS-CoV-2 variants

Contact tracing data from a new preprint study on the medRxiv* preprint server provides further evidence that the B.1.1.7 variant — first reported in the United Kingdom — has a high transmission rate. The research, led by Birgitte Freiseleben de Blasio from the Norwegian Institute of Public Health and the University of Oslo in Norway, estimates B.1.1.7 has a 60% greater transmission within households than other severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.

2 Apr 2021

Medical Science News

Can limiting the priming dose of a SARS-CoV-2 vaccine improve immunity?

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

Study suggests T-cells don't determine survival in severe COVID-19

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks

Devastating liver disease itching turns out to have a surprising cause

Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure

Different neural circuitries linked to distinct Parkinsonian behavioral deficits

Can universal vaccines and treatments against future SARS-CoV-2 variants be developed?

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

SARS-CoV-2 cryptic transmission modeling shows emergence of first wave in US and Europe

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

RNA-binding cylinders inhibit SARS-CoV-2 replication in vitro

Study paves way for effective monitoring of chemotherapeutic drug level in cancer patients

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

Treatment resistance in triple-negative breast cancers linked to softer tissue environment

Study uncovers novel mechanism in rare mutation associated with Alzheimer's

Combination of tumor cell vaccine and checkpoint therapy creates effective immune response

Research provides insights on why redheads exhibit altered sensitivity to pain

Higher B.1.1.7 transmission in households than other SARS-CoV-2 variants

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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