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Singapore researchers find common therapeutic vulnerability for a deadly blood cancer

CML is a blood cancer that can be controlled by continuously taking an expensive type of medicine called a tyrosine kinase inhibitor (TKI). In almost all patients, stopping TKI treatment results in recurrence of CML.

18 Mar 2020

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.

18 Mar 2020

Viewpoint: Could infectious pathogens play a role in Alzheimer's disease?

For researchers investigating Alzheimer's Disease (AD), a devastating neurodegenerative illness afflicting close to 6 million Americans, it is the best and worst of times.

18 Mar 2020

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

A research team led by Children's National Hospital faculty was able to "rescue" a pre-clinical model of fetal alcohol spectrum disorder in juvenile models, reversing motor skill deficits with the help of a novel drug derived from scorpion venom.

18 Mar 2020

C-Path and Lundbeck join hands to improve scientific community's insight in Alzheimer's

The Critical Path Institute and H. Lundbeck A/S are proud to announce that they will work together to significantly improve the scientific community's insight in Alzheimer's disease through Lundbeck's contribution of a unique set of clinical trial data from more than 2,500 AD patients to the Critical Path for Alzheimer's Disease consortium's integrated database for qualified researchers across the globe to access.

18 Mar 2020

Researchers study how changing seasons will affect coronavirus spread

One of the biggest unknowns about the coronavirus is how changing seasons will affect its spread. Physicists from the University of Utah have received the university's first COVID-19-related grant to tackle the question.

18 Mar 2020

Using 'organs-on-a-chip' to study chronic inflammatory diseases

MIT biological engineers have created a multitissue model that lets them study the relationships between different organs and the immune system, on a specialized microfluidic platform seeded with human cells.

18 Mar 2020

Bacterial extracellular vesicles could combat antibiotic resistance

Children's National Hospital researchers for the first time have isolated bacterial extracellular vesicles from the blood of healthy donors, a critical step to better understanding the way gut bacteria communicate with the rest of the body via the bloodstream.

18 Mar 2020

Immune mechanism in the brain appears to play key role in the development of Alzheimer's

An immune reaction in the brain seems to play a major role in the development of Alzheimer's disease. In a way, it "adds fuel to the fire" and apparently causes an inflammation that, in a sense, keeps kindling itself. The study has now been published in the journal Cell Reports.

18 Mar 2020

Novel Alzheimer's risk genes affect microglial response to amyloid-beta

Our DNA determines a large part of our risk for Alzheimer's disease, but it remained unclear how many genetic risk factors contribute to disease.

18 Mar 2020

UCLA researcher awarded NIH grant to study pain-relieving effects of cannabis chemicals

Ziva Cooper, research director of the UCLA Cannabis Research Initiative, has been awarded a $3.9 million grant from the National Center for Complementary and Integrative Health at the NIH to study whether cannabis chemicals called terpenes can reduce the amount of opioid medication a person needs to reduce pain.

18 Mar 2020

MCL1 protein essential in protecting the intestine against cancer development

An international team of researchers from the University of Zurich, the University Hospital Zurich, Heidelberg and Glasgow has identified a novel function for the cell death regulating protein MCL1: It is essential in protecting the intestine against cancer development – independent of bacterial-driven inflammation.

18 Mar 2020

COVID-19 epidemic is the product of natural evolution, study finds

The novel SARS-CoV-2 coronavirus that emerged in the city of Wuhan, China, last year and has since caused a large scale COVID-19 epidemic and spread to more than 70 other countries is the product of natural evolution, according to findings published today in the journal Nature Medicine.

17 Mar 2020

Researchers identify genetic signature linked to higher risk of preeclampsia

Researchers at Baylor College of Medicine have identified a genetic signature combining certain maternal and fetal gene variants that are associated with a higher risk of preeclampsia.

17 Mar 2020

New understanding of signaling molecule interleukin-2 can guide drug discovery efforts

The signaling molecule interleukin-2 (IL-2) has long been known to have powerful effects on the immune system, but efforts to harness it for therapeutic purposes have been hampered by serious side effects.

17 Mar 2020

Vaxxas' novel high-density microarray patch can deliver vaccines safely and effectively

Vaxxas, a clinical-stage biotechnology company commercializing a novel vaccination platform, today announced the publication in the journal PLoS Medicine of groundbreaking clinical research indicating the broad immunological and commercial potential of Vaxxas' novel high-density microarray patch.

17 Mar 2020

Odor alters how memories are processed in the brain, research reveals

In a new paper published in Learning and Memory, researchers from Boston University's Center for Systems Neuroscience reveal just how much power scents have in triggering the memory of past experiences--and the potential for odor to be used as a tool to treat memory-related mood disorders.

17 Mar 2020

Damaging the tumor blood vessels could be new strategy to treat oral cancer

Researchers at Okayama University have recently published a study in Cells in which they reduced the size of oral cancer tumors by damaging the blood vessels surrounding the tumor cells.

17 Mar 2020

TTP plc establishes new partnership to enable better clinical management of patients with atrial fibrillation

TTP plc, a leading independent technology and product development company, today announced it has established a partnership with NHS Highland and The University of the Highlands and Islands, to use clinical data interpretation and machine learning algorithms to predict which patients with atrial fibrillation are able to be successfully treated using electrical cardioversion.

17 Mar 2020

Melbourne researchers show the body's ability to fight novel coronavirus

Melbourne researchers have mapped immune responses from one of Australia's first novel coronavirus (COVID-19) patients, showing the body's ability to fight the virus and recover from the infection.

17 Mar 2020

Medical Science News

Singapore researchers find common therapeutic vulnerability for a deadly blood cancer

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

Viewpoint: Could infectious pathogens play a role in Alzheimer's disease?

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

C-Path and Lundbeck join hands to improve scientific community's insight in Alzheimer's

Researchers study how changing seasons will affect coronavirus spread

Using 'organs-on-a-chip' to study chronic inflammatory diseases

Bacterial extracellular vesicles could combat antibiotic resistance

Immune mechanism in the brain appears to play key role in the development of Alzheimer's

Novel Alzheimer's risk genes affect microglial response to amyloid-beta

UCLA researcher awarded NIH grant to study pain-relieving effects of cannabis chemicals

MCL1 protein essential in protecting the intestine against cancer development

COVID-19 epidemic is the product of natural evolution, study finds

Researchers identify genetic signature linked to higher risk of preeclampsia

New understanding of signaling molecule interleukin-2 can guide drug discovery efforts

Vaxxas' novel high-density microarray patch can deliver vaccines safely and effectively

Odor alters how memories are processed in the brain, research reveals

Damaging the tumor blood vessels could be new strategy to treat oral cancer

TTP plc establishes new partnership to enable better clinical management of patients with atrial fibrillation

Melbourne researchers show the body's ability to fight novel coronavirus

A new method to measure intracellular water in biological systems

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

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