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Combination regimen shows promising results in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone.

10 Dec 2019

ERC promotes CRISPR research to better treat infections

Chase Beisel heads the "Synthetic Biology of RNA" research group at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, a branch of the Helmholtz Centre for Infection Research in Braunschweig and run in collaboration with the Julius-Maximilians-Universität in Würzburg.

10 Dec 2019

UA physician-scientist to study how common stressors affect the aging process

The human body gets stressed every single day. Whether we contract a minor infection or even argue with a loved one, these small stressors impact our immune system.

10 Dec 2019

Study finds irregular brain function in children with Type 1 diabetes

Children with Type 1 diabetes show subtle but important differences in brain function compared with those who don't have the disease, a study led by researchers at the Stanford University School of Medicine has shown.

10 Dec 2019

Mitochondrial dysfunction may underlie prolonged muscle weakness after sepsis

Damage to energy-producing mitochondria may underlie prolonged muscle weakness following a sepsis-like condition in mice, according to a new study published today in eLife.

10 Dec 2019

Researcher receives ERC grant to explore the mechanism of the brain

You don't usually notice it, but you are, in fact, continuously learning how to walk. It happens when you first step onto a slippery sidewalk in a pair of new shoes, or when you try to carry a tray full of drinks.

10 Dec 2019

Genetic alteration increases risk of Autism and Tourette's impacts on the brain

Lancaster University researchers have discovered, for the first time, how a genetic alteration that increases the risk of developing Autism and Tourette's impacts on the brain.

10 Dec 2019

Risk of specific genetic translocation is higher in patients of African ancestry, shows study

Multiple myeloma is a plasma cell cancer that is more common in patients of African American descent than of European American descent.

10 Dec 2019

Scientists highlight the benefits of Droplet Digital PCR technology at the 2019 ASH meeting

Scientists will present more than 40 abstracts highlighting research driven in part by Bio-Rad Laboratories' Droplet Digital PCR (ddPCR) technology at the 2019 American Society of Hematology (ASH) meeting in Orlando Florida, December 7-10.

10 Dec 2019

Rutgers researchers identify small mutations for AML and MDS through deep DNA sequencing

Deep DNA sequencing analysis conducted by Rutgers Cancer Institute of New Jersey investigators examining genomic differences within tumors for prediction of disease relapse in certain hematologic malignancies has identified small mutations.

9 Dec 2019

Mapping genetic links between diseases using data from electronic health records

Physicians use standard disease classifications based on symptoms or location in the body to help make diagnoses. These classifications, called nosologies, can help doctors understand which diseases are closely related, and thus may be caused by the same underlying issues or respond to the same treatments.

9 Dec 2019

'Achilles' heel' of deadly superbug identified

A deadly superbug that infects an estimated 54,500 Americans a year has a secret weapon, a protein, that allows it to defy antibiotic treatment and immune system attacks.

9 Dec 2019

Lactobacillus balances intestinal microbiome and ameliorates chronic alcohol-induced liver injury

Researchers demonstrated that Lactobacillus rhamnosus can dose-dependently reestablish a balanced intestinal microbiome and counter the liver-damaging effects of alcohol consumption in mice to reverse the results of chronic alcohol-induced liver injury.

9 Dec 2019

Dead probiotic reduces age-related leaky gut in older mice, study finds

Scientists at Wake Forest School of Medicine have identified a dead probiotic that reduces age-related leaky gut in older mice. The study is published in the journal GeroScience.

9 Dec 2019

New software tool uses AI to recognize cancer cells from digital pathology images

UT Southwestern researchers have developed a software tool that uses artificial intelligence to recognize cancer cells from digital pathology images - giving clinicians a powerful way of predicting patient outcomes.

9 Dec 2019

New nanoparticle innovation detects vascular calcification in atherosclerosis

Heart disease and stroke are the world's two most deadly diseases, causing over 15 million deaths in 2016 according to the World Health Organization.

9 Dec 2019

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

New findings published Dec. 9 in Nature Biomedical Engineering from scientists at Fred Hutchinson Cancer Research Center show for the first time that a piece of small, thin metal mesh loaded with cancer-fighting immune cells shrinks tumors in preclinical models of ovarian cancer.

9 Dec 2019

Innovative experimental therapy may stop growth of triple-negative breast cancer

Mount Sinai researchers have designed an innovative experimental therapy that may be able to stop the growth of triple-negative breast cancer, the deadliest type of breast cancer, which has few effective treatment options, according to a study published in Nature Chemical Biology in December.

9 Dec 2019

Some phages employ new strategy to avoid becoming the next casualty of DNA-dicing enzymes

Bacteria and the viruses that infect them are engaged in a molecular arms race as ancient as life itself. Evolution has equipped bacteria with an arsenal of immune enzymes, including CRISPR-Cas systems, that target and destroy viral DNA. But bacteria-killing viruses, also known as phages, have devised their own tools to help them outmaneuver even the most formidable of these bacterial defenses.

9 Dec 2019

Neuroscientists show two nerve cells responsible for decision-making process

A penalty shootout at the Soccer World Cup. All eyes are on the best striker of the team. He should take the decisive shot, preferably past the goalkeeper. The striker must decide whether to aim for the right or left corner of the goal. In his brain, he plans both options before making the decision. If the goalkeeper's posture indicates that he will jump to the right at the decisive moment, the striker will develop a temporary preference for planning a movement to the left corner.

9 Dec 2019

Medical Science News

Combination regimen shows promising results in preclinical models of triple negative breast cancer

ERC promotes CRISPR research to better treat infections

UA physician-scientist to study how common stressors affect the aging process

Study finds irregular brain function in children with Type 1 diabetes

Mitochondrial dysfunction may underlie prolonged muscle weakness after sepsis

Researcher receives ERC grant to explore the mechanism of the brain

Genetic alteration increases risk of Autism and Tourette's impacts on the brain

Risk of specific genetic translocation is higher in patients of African ancestry, shows study

Scientists highlight the benefits of Droplet Digital PCR technology at the 2019 ASH meeting

Rutgers researchers identify small mutations for AML and MDS through deep DNA sequencing

Mapping genetic links between diseases using data from electronic health records

'Achilles' heel' of deadly superbug identified

Lactobacillus balances intestinal microbiome and ameliorates chronic alcohol-induced liver injury

Dead probiotic reduces age-related leaky gut in older mice, study finds

New software tool uses AI to recognize cancer cells from digital pathology images

New nanoparticle innovation detects vascular calcification in atherosclerosis

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

Innovative experimental therapy may stop growth of triple-negative breast cancer

Some phages employ new strategy to avoid becoming the next casualty of DNA-dicing enzymes

Neuroscientists show two nerve cells responsible for decision-making process

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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