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Fatty acid-binding protein 4 plays an important role in kidney stone formation

Kidney stone disease has a high prevalence worldwide, ranging up to 13% in North America, 9% in Europe, and 5% in Asia. They are painful for patients, often lead to surgery, and impart a significant economic impact.

23 Mar 2020

Study provides better understanding of how dangerous cancer metastases arise

In order to colonize other organs and grow into metastases, tumor cells that detach from the parent tumor need to manipulate their new microenvironment and create a 'metastatic niche'.

23 Mar 2020

Using cannabinoids for management of acute pain

A new systematic review and meta-analysis showed a small but significant reduction in subjective pain scores for cannabinoid treatment compared to placebo in patients experiencing acute pain.

23 Mar 2020

CAR macrophages can be used to effectively fight solid tumors

Chimeric antigen receptor (CAR) T cell therapy has been a game-changer for blood cancers but has faced challenges in targeting solid tumors.

23 Mar 2020

Graphite nanoplatelets on medical devices can prevent infections

Graphite nanoplatelets integrated into plastic medical surfaces can prevent infections, killing 99.99 per cent of bacteria which try to attach - a cheap and viable potential solution to a problem which affects millions, costs huge amounts of time and money, and accelerates antibiotic resistance.

23 Mar 2020

Wasan lab develops novel oral formulation to treat systemic fungal infections

The Wasan Laboratory in the Faculty of Pharmaceutical Sciences at the University of British Columbia in partnership with iCo Therapeutics Inc. (Vancouver BC, Canada) have developed a novel oral formulation of Amphotericin B to treat systemic fungal and parasitic infections.

23 Mar 2020

Melinjo seed extract may improve obesity and diabetes

In Southeast Asia, the fruit, flowers, and leaves of Indonesia's "Melinjo" tree are traditional foods.

23 Mar 2020

Tiny device can rapidly detect harmful bacteria in blood

Engineers have created a tiny device that can rapidly detect harmful bacteria in blood, allowing health care professionals to pinpoint the cause of potentially deadly infections and fight them with drugs.

23 Mar 2020

Research may help older adults maintain skeletal muscle mass and physical function for longer

Drug therapies that help older adults maintain their skeletal muscle mass and physical function for longer could be a step closer after researchers at the University of Birmingham identify a key mechanism that drives the clearance of damaged mitochondria.

22 Mar 2020

Using 'young NK cells' could improve the effectiveness of immunotherapy for cancer patients

Immunotherapy that involves treating cancer with the body's own immune cells, or those of a matched donor, shows promise in clinical trials for some patients, but not all.

22 Mar 2020

Newly discovered molecule in the lymphatic system could play a role in autoimmune diseases

A study by investigators at Hospital for Special Surgery has discovered a molecule in the lymphatic system that has the potential to play a role in autoimmune disease.

22 Mar 2020

A review of the literature on acute promyelocytic leukemia

Oncotarget Volume 11, Issue 11 reported that relapsed APL, particularly in the high-risk subset of patients, remains an important clinical problem.

22 Mar 2020

Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly monitored during the first month of therapy.

22 Mar 2020

Discovery shows a novel opportunity for DOT1L inhibitors in cancer treatment

Oncotarget Volume 11, Issue 11 reported that in order to understand the molecular mechanism of the dependency in MM, the research team examined gene expression changes upon DOT1L inhibition in sensitive and insensitive cell lines and discovered that genes belonging to the endoplasmic reticulum stress pathway and protein synthesis machinery were specifically suppressed in sensitive cells.

22 Mar 2020

Researcher working to measure gene expression in blood of patients treated for opioid use disorder

MingKuan Lin, Research Assistant Professor, INOVA Neuroscience, School of Systems Biology, is working to measure gene expression levels in blood from patients undergoing treatment with buprenorphine for opioid use disorder.

22 Mar 2020

New drug can alleviate the side effects of tricyclic antidepressants

About one in five Danes are affected by depression at some point in their lives. The severe depressions may be treated with the so-called 'tricyclic antidepressants', an antidepressant drug that is more effective than the drugs used for mild and moderate depressions.

22 Mar 2020

Lance Liotta receives $72,000 for collaborative project

Lance Liotta, Co-Director, Applied Proteomics and Molecular Medicine, received $72,000 from Queensland University of Technology for the project: "The Systems Biochemistry of Adaptation in Cellular Protein Networks." Australian Research Council Future Fellowship (total $784,680).

22 Mar 2020

DFG underlines the need for long-term, knowledge-driven basic research

In view of the coronavirus pandemic, the Deutsche Forschungsgemeinschaft has underlined the need for long-term, knowledge-driven basic research.

21 Mar 2020

Lab-on-chip device to monitor how extracellular matrix responds to disease

Similarly to how a picked lock gives away that someone has broken into a building, the stiffening of a structure surrounding cells in the human body can indicate that cancer is invading other tissue.

21 Mar 2020

Preclinical study characterizes the binding affinity and selectivity of a selective FLT3 inhibitor

Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with those of other FLT3 inhibitors.

21 Mar 2020