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Scientists gain new insight into aggressive breast cancers

Scientists from Cardiff University have uncovered a protein which drives aggressive breast cancer and could be targeted for developing new and improved therapies.

27 Dec 2018

Researchers develop vaccine effective against emerging tick-borne virus in mice

A group of researchers led by Michael Diamond of Washington University in St. Louis have developed a vaccine that is effective in mice against Powassan virus, an emerging tick-borne virus that can cause life-threatening encephalitis in humans.

27 Dec 2018

New review focuses on the structure-activity relationships of flavonoids

ABCB1 in the ABC transporter family also termed as P-glycoprotein, grants the simultaneous resistance of metastatic cancer cells towards various anti-cancer drugs with different targets and diverse chemical structures.

27 Dec 2018

Targeting thymidylate biosynthesis in kinetoplastid and apicomplexan protozoans

Kinetoplastid and apicomplexan parasites include protozoans which are responsible for human diseases, and cause a serious impact on human health and the socioeconomic growth of developing countries. Chemotherapy is the main option to control these pathogenic organisms.

27 Dec 2018

Study uncovers how skin ages, loses fat and immunity

Dermal fibroblasts are specialized cells deep in the skin that generate connective tissue and help the skin recover from injury. Some fibroblasts have the ability to convert into fat cells that reside under the dermis, giving the skin a plump, youthful look and producing a peptide that plays a critical role in fighting infections.

27 Dec 2018

Research findings expand understanding of how memory works

Two Veterans Affairs researchers have explored how memory is tied to the hippocampus, with findings that will expand scientists' understanding of how memory works.

27 Dec 2018

Scientists suggest need for new approach to confront side effects of common anti-cancer therapy

Results of a new study by neuroscientists at the University of Massachusetts Amherst and the University of Toronto suggest that a new treatment approach is needed - and how this may be possible - to address adverse effects of aromatase inhibitors, drugs commonly prescribed to both men and women to prevent recurrence of estrogen-positive breast cancer.

27 Dec 2018

Neuronal cell death in Alzheimer's disease may actually not be a bad thing, shows study

For the first time, scientists at the Champalimaud Centre for the Unknown, in Lisbon, Portugal, have shown that neuronal cell death in Alzheimer's disease may actually not be a bad thing - on the contrary, it may be the result of a cell quality control mechanism trying to protect the brain from the accumulation of malfunctioning neurons.

27 Dec 2018

New study reveals twist in how intoxication happens

As New Year's Eve approaches, many people will experience the familiar buzz that comes from imbibing a favorite cocktail or glass of wine.

27 Dec 2018

Study: Reactivation of HIV-infected cells depends on its size and cell cycle

Thanks to the development of antiretroviral drugs, human immunodeficiency virus is considered a manageable chronic disease today.

27 Dec 2018

NIPER researcher presents a review on autophagy in neuronal cells

Autophagy is a cellular degradation process that can cause the death of a cell in certain conditions. Autophagy is necessary to maintain cellular homeostasis by clearing out damaged cellular organelles and proteins through certain pathways.

27 Dec 2018

Using untargeted metabolomics to find biomarkers and therapeutic targets for CVD

Cardiovascular diseases are proven to be the leading cause of deaths throughout the world. If statistics are reviewed, almost four out of five deaths are due to myocardial infarction or stroke. Efforts to prevent CVD have little effect on the decrease of the number of CVD related deaths despite many medical advances.

26 Dec 2018

Study investigates role of miRNAs in anesthetic-induced myocardial conditioning

Many studies have shown that the mechanism of drug-induced myocardial conditioning is enzyme-mediated through messenger RNA and miRNA regulation. In this study Orriach et al. investigated the role that miRNAs play in the cardio-protective effect of halogenated anesthetics, which are widely used in cardiac surgery.

26 Dec 2018

New method of cancer stem cells activation to destroy tumors

This risky method of anti-cancer therapy was suggested by scientists of Far Eastern Federal University (FEFU). Their review of mechanisms for molecular activation of stem cells of gliomas (most widely-spread brain tumors) was approved for publishing in the Frontiers in Cellular Neuroscience journal.

26 Dec 2018

New mechanism may explain neurons shrinking in Huntington's disease

A hallmark of neurodegenerative diseases like Huntington's is the progressive death of nerve cells in the brain. The cells don't die quickly, though. They first start to disconnect from each other because their neurites -- long finger-like extensions that make connections all through the brain -- become smaller.

25 Dec 2018

Brain activity found to be predictive of pain-related fear

Researchers applied a machine learning technique that could potentially translate patterns of activity in fear-processing brain regions into scores on questionnaires used to assess a patient's fear of pain. This neuroscientific approach, reported in eNeuro, may help reconcile self-reported emotions and their neural underpinnings.

25 Dec 2018

Neuroimaging study explores how socioeconomic status shapes developing brains

The relationship between socioeconomic status and brain anatomy is mostly stable from childhood to early adulthood, according to a longitudinal neuroimaging study of more than 600 healthy young people published in JNeurosci.

25 Dec 2018

Study reveals side effects of breast cancer drug on brain function

A comprehensive study of monkeys given the breast cancer drug letrozole reveals side effects that impact the brain. Published in JNeurosci, the research establishes the common marmoset as an important nonhuman primate model for studying the effects of estrogen-reducing treatments on the nervous system.

25 Dec 2018

The role of galanin-like peptide in regulating feeding behavior and energy metabolism

Galanin-like peptide is a short peptide made up of 60 amino acid residues. This sequence is homologous across several species. The hypothalamic arcuate nucleus is the place where GALP is produced. GALP has diverse physiological effects such as the regulation of feeding, energy metabolism, and reproductive behavior.

25 Dec 2018

Scientists discover two therapies that slow progression of pediatric leukemia in mice

Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years in the journal Cell, and the final paper published Dec. 20 in Genes & Development.

24 Dec 2018