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Study reports promising novel approach to treat therapy resistant pediatric brain tumors

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children.

17 Apr 2018

Research reveals new mechanism by which HIV evades the immune system

Scientists have just discovered a new mechanism by which HIV evades the immune system, and which shows precisely how the virus avoids elimination. The new research shows that HIV targets and disables a pathway involving a number of biological molecules that are key in blocking viral activity and clearing infection.

17 Apr 2018

Mouse study shows how tungsten accumulates in the bones

New research shows how and where tungsten accumulates in bones of mice exposed to the element through drinking water. The findings, by a team of chemists and biologists at McGill University, could add to doubts over the once-universal assumption that tungsten poses little or no health risk to the general human population.

17 Apr 2018

Study shows presence of beta-amyloid dimers in the brains of Alzheimer's patients

The most widely used biomarkers for the early detection of Alzheimer's disease (AD) are currently the concentrations of beta-amyloid and phosphorylated Tau in cerebrospinal fluid. However, it has been observed that not all individuals with alterations in these biomarkers develop the disease.

17 Apr 2018

Two immune checkpoint inhibitors efficiently block leukemia development in preclinical tests

Chronic lymphocytic leukemia is a hematological malignancy that originates in the blood-forming cells of the bone marrow and spreads to other organs through the bloodstream.

17 Apr 2018

Researchers shed light on role of striosomal neurons in reinforcement learning

A pleasant surprise or a nasty shock is likely to be a memorable experience. For instance, if you touch a hot oven, you very quickly learn not to do it again.

17 Apr 2018

Specific odors from malaria infected individuals attract more mosquitoes

Malaria causes the bodies of its human hosts to emit specific odors from the skin that make the hosts even more attractive to mosquitoes, which invites further bites and risks infection of more mosquitoes and wider transmission of the disease.

17 Apr 2018

Antimicrobial therapy can prevent occurrence of pneumococcal septicemia

Antimicrobial therapy targeting specific cells in the immune system could prevent sepsis and life-threatening disease in people suffering from pneumonia, new research led by the University of Leicester has shown.

17 Apr 2018

Large ALS-causing protein aggregates protect rather than harm neurons

Scientists at the UNC School of Medicine have made a significant advance in the understanding of the complex and fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

17 Apr 2018

Antioxidant treatment may decrease cardiovascular risk in women with type 1 diabetes

The high estrogen levels that typically afford younger women protection from cardiovascular disease appear to instead multiply their risk if they have type 1 diabetes, researchers say.

17 Apr 2018

Researchers generate stable cartilage tissue from adult mesenchymal stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

16 Apr 2018

MD Anderson research provides insight into memory T cell development and disease relapse

Just like people, some T cells have excellent memories. These subtypes known as memory T cells may explain why some immunotherapies are more effective than others and potentially lead to researchers designing more effective studies using combination checkpoint blockade treatments, according to experts at The University of Texas MD Anderson Cancer Center.

16 Apr 2018

Research sheds light on links between brain growth and post-natal sensory experiences

New research by University of Toronto neuroscientists sheds light on links between early brain growth and sensations experienced by animals soon after birth.

16 Apr 2018

Precancerous colon polyps in Lynch syndrome patients display immune activation

Colon polyps from patients with Lynch syndrome, a hereditary condition that raises colorectal cancer risk, display immune system activation well before cancer development, according to research from The University of Texas MD Anderson Cancer Center.

16 Apr 2018

Early life stress impacts how the sensory systems develop, review shows

Life needs stimulation. However, overstimulation can cause exhaustion and illness. During specific sensitive periods early in life, stress can even affect later mental health.

16 Apr 2018

Engineered immune cells clear deadly pediatric brain tumor in mice

Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated.

16 Apr 2018

Novel disease model for ALS and MS can be used to develop new immunotherapies

Researchers at Karolinska Institutet in Sweden have developed a new disease model for neurodegenerative diseases such as ALS and MS that can be used to develop new immunotherapies. The model is described in a publication in the scientific journal Nature Immunology.

16 Apr 2018

Study shows connection between early life stress, depression and sleep disturbances

Early life stress, sleep disturbances and alterations in neuronal plasticity have been associated with depression, yet the relation between these factors and depression remain poorly understood.

16 Apr 2018

Deficiency of innate immune adaptor TRIF shortens survival time of ALS mice

Amyotrophic lateral sclerosis is a neurodegenerative disease damaging motor neurons in brain and spinal cords. ALS patients show progressive muscle weakness and atrophy, leading to a fatal respiratory muscle paralysis. There are no effective therapies for ALS.

16 Apr 2018

Finding ways to reverse obesity’s lingering, pro-cancer effects

Like exposure to too much sun and drinking alcohol, obesity is a risk factor for cancer. Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center are working to be a part of the solution -- they want to find ways to reverse obesity-linked biological changes in the body that are associated with cancer growth.

16 Apr 2018