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Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects

Revealing surprising answers to a long-standing enigma about the brain target of the anti-obesity hormone leptin, neuroscientists at Tufts University School of Medicine have used CRISPR genome editing to identify a neural circuit in the hypothalamus as the primary mechanism in mediating leptin's anti-obesity and anti-diabetes effects and have identified two distinct mechanisms underlying leptin's inhibition of appetite.

19 Apr 2018

New insight may allow researchers to design drugs that improve immune responses to vaccines

Memory T cells are a critical element of our immune system's historical archive. To prevent repeat infections, these cells retain a record of germs they've fought before.

19 Apr 2018

Researchers use optogenetics to treat chronic pain

The finger prick from a thorn generates an immediate sensory response. In that instant, neurons at the injury site fire an electrical signal along a nerve fiber to the central nervous system. Our brain notes to avoid further encounters with thorns and the painful insult subsides.

18 Apr 2018

Functional connectivity MRI could help detect brain disorders and diseases

There are no laboratory tests to diagnose migraines, depression, bipolar disorder and many other ailments of the brain. Doctors typically gauge such illnesses based on self-reported symptoms and behavior.

18 Apr 2018

Direct electrical current can be delivered to nerves for blocking pain signals

Using computer models and laboratory rats, Johns Hopkins researchers have demonstrated that "direct electrical current" can be delivered to nerves preferentially, blocking pain signals while leaving other sensations undisturbed.

18 Apr 2018

Novel stem cell therapy may transform current paradigms for treating heart failure patients

Clinical trial planning is underway at MedStar Heart & Vascular Institute to determine whether a novel stem cell therapy will improve heart function for patients with heart failure.

18 Apr 2018

UT Southwestern scientists discover protein linked to metastatic breast cancer

Researchers at UT Southwestern Medical Center have identified a protein that is strongly associated with metastatic breast cancer and that could be a target for future therapies.

18 Apr 2018

Compound derived from immune cells treats psoriasis in mice

A compound derived from immune cells treats psoriasis in mice and holds promise for other autoimmune diseases, according to a new study from Washington University School of Medicine in St. Louis.

18 Apr 2018

Study proposes new mechanism that may contribute to gender differences in weight control

For years, scientists have observed that when male and female mice eat the same high-fat diet, the males gain significantly more weight than the females.

18 Apr 2018

Study: Transplanted livers have a protective effect and reduce potential for organ rejection

Transplanted livers change the profile of blood cells in the recipients, reducing the potential for organ rejection, Mayo Clinic research shows.

18 Apr 2018

Researchers discover unique protein in malaria parasite that could be new drug target

Over a thousand people die from malaria every day. The disease is caused by a single-cell parasite (protozoan) that is transmitted by mosquitoes. Anti-malaria efforts currently focus on effective diagnostics, mosquito nets, insecticides and drugs.

18 Apr 2018

Researchers build molecular networks of calcific aortic valve disease

Calcific aortic valve disease - a disease that leaves the aortic valve stiff and calcified, preventing blood flow from the heart into the aorta - affects one quarter of the U.S. population aged 65 and over.

18 Apr 2018

Tradeshow Talks with HealthSapiens

Tradeshow Talks with HealthSapiens - democratizing healthcare, with their peer-to-peer platform

18 Apr 2018

Researchers clarify immune response for patients with breast cancer brain metastases

Once it has begun to spread in the body, approximately half of patients with an aggressive breast cancer type will develop cancer in the brain. Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center want to improve treatment for patients with breast cancer brain metastases, but using the body's existing defenses - the immune system.

18 Apr 2018

New study maps links between 625 genes and different chemotherapy treatments

Despite the great successes of targeted cancer drugs and the promise of novel immunotherapies, the vast majority of people diagnosed with cancer are still first treated with chemotherapy. Now a new study by UCSF researchers using techniques drawn from computational biology could make it much easier for physicians to use the genetic profile of a patient's tumor to pick the chemotherapy treatment with the fewest side effects and best chance of success.

18 Apr 2018

Gene affects some women's body fat distribution and increases their diabetes risk

A natural variation of the gene KLF14 causes some women to store fat on their bellies and hips and puts them at significantly increased risk of type 2 diabetes, new research reveals.

17 Apr 2018

Children with autism have gastrointestinal and immune system deregulation, research finds

Researchers at the UC Davis MIND Institute have found that children with autism spectrum disorder have reduced immune system regulation, as well as shifts in their gut microbiota.

17 Apr 2018

Roswell Park researchers identify driver of cancer-promoting metabolic changes

Roswell Park Comprehensive Cancer Center researchers have identified a potential key player promoting cancer progression through changes in the cell environment that are conducive to metastasis.

17 Apr 2018

Students develop one-size-fits-all, inexpensive embolization tool

Stemming the flow of blood to starve a tumor or stop hemorrhage can be an expensive, repetitive task for doctors, requiring a variety of approaches and materials for different patients and different sized blood vessels. Often, the interventional radiologists who perform these important procedures must try several times in order to successfully stop the bleeding.

17 Apr 2018

Some human cancers may be result of evolutionary accidents, research finds

New research, published in Biological Reviews and conducted by researchers from the University of Liverpool and Escola Superior de Ciências da Saúde (Brasília, Brazil) has found some type of cancers unique to humans may be a result of evolutionary accidents.

17 Apr 2018

Medical Science News

Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects

New insight may allow researchers to design drugs that improve immune responses to vaccines

Researchers use optogenetics to treat chronic pain

Functional connectivity MRI could help detect brain disorders and diseases

Direct electrical current can be delivered to nerves for blocking pain signals

Novel stem cell therapy may transform current paradigms for treating heart failure patients

UT Southwestern scientists discover protein linked to metastatic breast cancer

Compound derived from immune cells treats psoriasis in mice

Study proposes new mechanism that may contribute to gender differences in weight control

Study: Transplanted livers have a protective effect and reduce potential for organ rejection

Researchers discover unique protein in malaria parasite that could be new drug target

Researchers build molecular networks of calcific aortic valve disease

Tradeshow Talks with HealthSapiens

Researchers clarify immune response for patients with breast cancer brain metastases

New study maps links between 625 genes and different chemotherapy treatments

Gene affects some women's body fat distribution and increases their diabetes risk

Children with autism have gastrointestinal and immune system deregulation, research finds

Roswell Park researchers identify driver of cancer-promoting metabolic changes

Students develop one-size-fits-all, inexpensive embolization tool

Some human cancers may be result of evolutionary accidents, research finds

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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