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VUMC’s Undiagnosed Diseases Network solves medical mysteries using advanced technologies

It's human nature to need answers. Patients with debilitating symptoms need a diagnosis — somewhere to place the blame, a starting point to search for answers.

14 Mar 2017

Study traces molecular roots of uterine carcinosarcoma using genomic, proteomic analyses

Researchers have charted the complex molecular biology of uterine carcinosarcoma, a rare and aggressive gynecologic cancer, according to a study published on March 13 in Cancer Cell.

13 Mar 2017

Exposure to EDCs alters thyroid hormone signalling, early brain development in frog embryos

Findings published today provide evidence that exposure to endocrine disrupting chemicals (EDCs) causes changes in thyroid hormone signalling, which disturbs brain development.

13 Mar 2017

Pre-existing immunity to dengue virus modulates T cell response to Zika infection

Although Zika and dengue are considered different virus "species," they are so closely related that the immune system treats Zika just like another version of dengue, report researchers at La Jolla Institute for Allergy and Immunology.

13 Mar 2017

Beneficial bacteria may be key to reverse gut inflammation seen in inflammatory bowel diseases

Beneficial bacteria may be the key to helping to reverse a cycle of gut inflammation seen in certain inflammatory bowel diseases, University of North Carolina Lineberger Comprehensive Cancer Center researchers have found.

13 Mar 2017

Novel androgens play major role in development of PCOS, research shows

Scientists led by the University of Birmingham have discovered that a new class of male sex hormones known as androgens plays a key role in the development of polycystic ovary syndrome (PCOS).

13 Mar 2017

New approach shows promise to prevent, treat cholesterol gallstone disease

According to current estimates, 20 to 25 million Americans have or will develop gallstones, representing almost 15% of adults. Although only a small percentage of individuals with gallstones develop symptoms, more than 700,000 individuals annually undergo surgical gallbladder removal and many more take medications to manage the condition or undergo stone-dissolving procedures.

13 Mar 2017

UGR scientists show link between magnetic systems and certain states of brain activity

Scientists from the University of Granada (UGR) have proven for the first time that there is a close relationship between several emerging phenomena in magnetic systems (greatly studied by condensed matter physicists) and certain states of brain activity.

13 Mar 2017

Swansea University experts assess contribution of ultra-rare genetic variation in common epilepsies

Despite progress in understanding the genetics of rare childhood epilepsies, the common adult forms of epilepsy have proven less amenable to traditional gene-discovery analyses.

13 Mar 2017

Researchers produce images that predate formation of beta-amyloid plaques in Alzheimer’s disease

Researchers at Lund University in Sweden have used the MAX IV synchrotron in Lund - the strongest of its kind in the world - to produce images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer's disease.

13 Mar 2017

Evolution of immuno-oncology

Immuno-oncology did not exist four years ago, it's a term coined by Dr. Axel Hoos, Head of the newly defined immuno-oncology department at GSK. He is also Senior Vice President Therapeutic Area (TA) and Head for Oncology R&D. Previously, it was referred to as cancer immunotherapy, but now it is called immuno-oncology (IO).

13 Mar 2017

UCL scientists develop way to use MRI scans for identifying HIV in the brain

Scientists at UCL have developed a way to use MRI scans to help identify when HIV is persisting in the brain despite effective drug treatment.

13 Mar 2017

Targeting cancer stem cells may be effective way to prevent spread of squamous cell carcinoma

Targeting cancer stem cells may be a more effective way to overcome cancer resistance and prevent the spread of squamous cell carcinoma — the most common head and neck cancer and the second-most common skin cancer, according to a new study by cancer researchers at the UCLA School of Dentistry.

10 Mar 2017

Brain networks at rest appear to be in state of potentiation for action, study suggests

Just as a sprinter's body and muscles are ready for action as they wait for the starting gun to fire, brain networks at rest appear to be waiting in a state of potentiation to execute even the simplest of behaviors.

10 Mar 2017

Endostatin can decrease proliferation of castration-resistant prostate cancer cells

Failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatment options.

10 Mar 2017

Investigational RSV vaccine protects cattle from respiratory diseases

A novel vaccine developed by scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, protected cattle from respiratory syncytial virus (RSV) infection, according to research published online in npj Vaccines on March 8.

10 Mar 2017

Researchers discover intestinal quiescent stem cells that are resistant to chemotherapy

The intestine has a high rate of cellular regeneration due to the wear and tear originated by its function degrading and absorbing nutrients and eliminating waste. The entire cell wall is renewed once a week approximately.

10 Mar 2017

Rutgers study discovers that chemical used to detect amyloid plaques increases roundworm lifespan

While many anti-aging drugs don't live up to their claim, a tightly replicated study by Rutgers and a group of researchers from around the country discovered that a chemical used to detect amyloid plaques found in the brains of those with Alzheimer's extended the lifespan of thousands of roundworms similar in molecular form, function and genetics to humans.

10 Mar 2017

Discovery of link between RNA quality control and longevity may shed light on mechanisms behind aging

The vigors of youth and the greener pastures of yesteryears. Some might refer to these and other similar clichés as nothing more than rose-tinted literations of the past; a cognitive side effect of life.

10 Mar 2017

Researchers take important step forward in disabling cancer cells' defences

Recent study out of the University of Ottawa opens door for new disease therapies in cancer, ALS, Fragile X Syndrome and others.

10 Mar 2017

Medical Science News

VUMC’s Undiagnosed Diseases Network solves medical mysteries using advanced technologies

Study traces molecular roots of uterine carcinosarcoma using genomic, proteomic analyses

Exposure to EDCs alters thyroid hormone signalling, early brain development in frog embryos

Pre-existing immunity to dengue virus modulates T cell response to Zika infection

Beneficial bacteria may be key to reverse gut inflammation seen in inflammatory bowel diseases

Novel androgens play major role in development of PCOS, research shows

New approach shows promise to prevent, treat cholesterol gallstone disease

UGR scientists show link between magnetic systems and certain states of brain activity

Swansea University experts assess contribution of ultra-rare genetic variation in common epilepsies

Researchers produce images that predate formation of beta-amyloid plaques in Alzheimer’s disease

Evolution of immuno-oncology

UCL scientists develop way to use MRI scans for identifying HIV in the brain

Targeting cancer stem cells may be effective way to prevent spread of squamous cell carcinoma

Brain networks at rest appear to be in state of potentiation for action, study suggests

Endostatin can decrease proliferation of castration-resistant prostate cancer cells

Investigational RSV vaccine protects cattle from respiratory diseases

Researchers discover intestinal quiescent stem cells that are resistant to chemotherapy

Rutgers study discovers that chemical used to detect amyloid plaques increases roundworm lifespan

Discovery of link between RNA quality control and longevity may shed light on mechanisms behind aging

Researchers take important step forward in disabling cancer cells' defences

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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