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Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy-induced neuropathy and HIV.

18 Jan 2017

Researchers test new HIV neutralising antibody in humans

A research team led by investigators of the Rockefeller University in New York and Prof Florian Klein, University Hospital Cologne and German Center for Infection Research, has tested a new HIV neutralising antibody, called 10-1074, in humans.

18 Jan 2017

Researchers discover role of neuron protein in learning abilities and AIDS-related dementia

Researchers from the University of California and Cardiff University have made a breakthrough in the understanding of AIDS-related dementia, discovering the role of a neuron protein which was also found to affect learning abilities in healthy subjects.

18 Jan 2017

Calorie restriction helps rhesus monkeys lead longer and healthier lives, report shows

Settling a persistent scientific controversy, a long-awaited report shows that restricting calories does indeed help rhesus monkeys live longer, healthier lives.

18 Jan 2017

Research findings could offer ways of fighting treatment resistance in oesophageal cancer

Researchers at Trinity College Dublin have made exciting new findings that could offer a means of fighting resistance to treatment for people with oesophageal cancer.

18 Jan 2017

Study provides insights into CPEB4 gene and fatty liver disease

This condition generally leads to chronic inflammation (non-alcoholic steatohepatitis), which can trigger fibrosis, cirrhosis and ultimately liver cancer. This study on the basic biology of the liver paves the way to examine therapeutic strategies to fight and prevent fatty liver disease.

18 Jan 2017

Inactive B2M genes can condition response of lung cancer patients to immunotherapy, study shows

Researchers from the Genes and Cancer research group at the Bellvitge Biomedical Research Institute have identified inactivating mutations in a number of genes that code for HLA-I histocompatibility complex proteins, which are involved in the immune response and can condition the tesponse of lung cancer patients to immunotherapy.

18 Jan 2017

Scientists identify how early responses of immune system can affect development of EBOV disease

A new mouse model of early Ebola virus infection has shown National Institutes of Health (NIH) scientists and colleagues how early responses of the immune system can affect development of EBOV disease.

18 Jan 2017

People with metabolic syndrome may need more vitamin E, new research shows

New research has shown that people with metabolic syndrome need significantly more vitamin E - which could be a serious public health concern, in light of the millions of people who have this condition that's often related to obesity.

17 Jan 2017

Penn researchers discover antimicrobial that thwarts Zika viral entry into human cells

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

17 Jan 2017

Research offers new clues to prolong lifespan of the body's disease-fighting NK cells

A team of researchers from Australia and France have uncovered new insights into how to prolong the lifespan of the body's disease-fighting natural killer (NK) cells.

17 Jan 2017

Chemotherapy-induced senescent cells promote side effects and cancer relapse

Standard chemotherapy is a blunt force instrument against cancer - and it's a rare cancer patient who escapes debilitating side effects from systemic treatments that mostly affect dividing cells, both malignant and healthy, throughout the body.

17 Jan 2017

Talking therapy strengthens connections in the brains of people with psychosis, study shows

A new study from King's College London and South London and Maudsley NHS Foundation Trust has shown for the first time that cognitive behaviour therapy strengthens specific connections in the brains of people with psychosis, and that these stronger connections are associated with long-term reduction in symptoms and recovery eight years later.

17 Jan 2017

Analgesic effects of opioids can be mediated via immune cells

Opioids are the most powerful painkillers. Researchers at the Charité - Universitätsmedizin Berlin have now found that the analgesic effects of opioids are not exclusively mediated by opioid receptors in the brain, but can also be mediated via the activation of receptors in immune cells.

17 Jan 2017

Diminishing levels of GABA may play role in age-related cognitive decline

Diminishing levels of GABA, the primary inhibitory neurotransmitter in the brain, may play a role in cognitive decline as we age, according to a study published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

17 Jan 2017

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

17 Jan 2017

Synthesized steroid prevents lethal protein buildup in animal model of Parkinson's disease

A synthesized steroid mirroring one naturally made by the dogfish shark prevents the buildup of a lethal protein implicated in some neurodegenerative diseases, reports an international research team studying an animal model of Parkinson's disease.

17 Jan 2017

Ludwig study uncovers ancient cellular response that underlies spread of aggressive skin cancer

Each day, more than 1,600 people die from cancer in the US, and 450 in the UK, mostly because the disease has spread beyond a stage when surgery is an effective cure and has become resistant to therapy. Despite decades of research, understanding why cancer cells become invasive has remained shrouded in mystery.

17 Jan 2017

Biomarker could help identify heart failure patients suitable for cardiac recovery therapies

Investigators at the University of Utah have identified distinct differences in the hearts of advanced heart failure patients who have defied the odds and showed signs of recovery from the disease. Published online in the journal Circulation, the new findings could help clinicians identify the best candidates for cardiac recovery therapies.

17 Jan 2017

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Massachusetts General Hospital investigators have identified a protein that may play an essential role in maintaining a population of tumor-initiating cells (TICs) -- treatment-resistant cells responsible for cancer recurrence and metastasis -- in breast cancer, as well as a compound that appears to reduce the molecule's ability to protect TICs from the effects of chemotherapy.

17 Jan 2017

Medical Science News

Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Researchers test new HIV neutralising antibody in humans

Researchers discover role of neuron protein in learning abilities and AIDS-related dementia

Calorie restriction helps rhesus monkeys lead longer and healthier lives, report shows

Research findings could offer ways of fighting treatment resistance in oesophageal cancer

Study provides insights into CPEB4 gene and fatty liver disease

Inactive B2M genes can condition response of lung cancer patients to immunotherapy, study shows

Scientists identify how early responses of immune system can affect development of EBOV disease

People with metabolic syndrome may need more vitamin E, new research shows

Penn researchers discover antimicrobial that thwarts Zika viral entry into human cells

Research offers new clues to prolong lifespan of the body's disease-fighting NK cells

Chemotherapy-induced senescent cells promote side effects and cancer relapse

Talking therapy strengthens connections in the brains of people with psychosis, study shows

Analgesic effects of opioids can be mediated via immune cells

Diminishing levels of GABA may play role in age-related cognitive decline

Epigenetic changes drive successful metastases of pancreatic cancer cells

Synthesized steroid prevents lethal protein buildup in animal model of Parkinson's disease

Ludwig study uncovers ancient cellular response that underlies spread of aggressive skin cancer

Biomarker could help identify heart failure patients suitable for cardiac recovery therapies

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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