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Scientists develop model using transformed stem cells to accelerate screening of drugs for rare cancers

Researchers at the Johns Hopkins Kimmel Cancer Center say they have developed a system that uses transformed human stem cells to speed up screening of existing drugs that might work against rare brain and other cancers.

2 Aug 2016

Preclinical data on Selecta’s novel immune tolerance platform published in Nature Nanotechnology

Selecta Biosciences, Inc., a clinical-stage biopharmaceutical company developing targeted antigen-specific immune therapies for rare and serious diseases, announced today that Nature Nanotechnology has published an article that presents preclinical results from Selecta’s research which demonstrate the broad potential applicability of Selecta’s novel immune tolerance platform.

2 Aug 2016

Researchers shed light on mechanism for inducing memory B cell differentiation

A group of researchers at Immunology Frontier Research Center (IFReC), Osaka University and RIKEN Center for Integrative Medical Sciences jointly clarified the mechanism for inducing germinal-center B cells' differentiation into memory B cells, immune cells that remember antigens, at the molecular level.

2 Aug 2016

Scientists observe reaction of neurons in real-time after concussive trauma

A team of Brown University researchers has been able to watch in real time what happens to neurons after they experience the kinds of forces involved in a blow to the head.

2 Aug 2016

New review proposes neuroscience-based framework for diagnosis of addictive disorders

When it comes to an addictive disorder, you either have it or you don't. But this dichotomous nature of the diagnosis fails to recognize the complexity and diversity of addiction's origins and manifestation in people.

2 Aug 2016

Scientists use animal model to gain better understanding of cocaine addiction

Scientists at Wake Forest Baptist Medical Center are one step closer to understanding what causes cocaine to be so addictive. The research findings are published in the current issue of the Journal of Neuroscience.

2 Aug 2016

GW researchers identify new way to regulate chronic toxoplasmosis

New research critical to treatment for chronic toxoplasmosis, one of the most common parasitic diseases worldwide, was published in the Journal of Experimental Medicine.

2 Aug 2016

TSRI study unveils new twist in immune biology

A new study, led by scientists at The Scripps Research Institute, reveals a surprising twist in immune biology.

2 Aug 2016

Iron-containing catalysts can alter amino acids to help develop new drug candidates

For medicinal chemists, making tweaks to peptide structures is key to developing new drug candidates. Now, researchers have demonstrated that two iron-containing small-molecule catalysts can help turn certain types of amino acids -- the building blocks of peptides and proteins -- into an array of potential new forms, even when part of a larger peptide, while preserving a crucial aspect of their chemistry: chirality, or "handedness."

2 Aug 2016

UCI molecular biologists find new way to combat skin cancer

Using new and innovative immune-therapeutic approaches to silence "don't eat me" signaling proteins recognized by specialized cells of the immune system, University of California, Irvine molecular biologists and their colleagues have identified an effective way to combat metastatic melanoma.

2 Aug 2016

Paternal over-nutrition may lead to generational obesity and metabolic dysfunction

Paternal intake of a high-fat diet (HFD) can cause genetic changes that lead to generational obesity and metabolic dysfunction—including body weight and fat mass increases and changes in blood pressure, triglyceride levels and fat metabolism—in mice, according to Japanese researchers at Okayama University.

2 Aug 2016

Early initiation of antiretroviral therapy can considerably reduce total HIV DNA levels

A team of researchers, led by Drs. Merlin Robb and Jintanat Ananworanich of the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research, has found that when antiretroviral therapy (ART) is initiated during early acute HIV infection, it can significantly reduce total HIV DNA levels in the body, which may have implications for the goal of achieving long-term HIV remission.

2 Aug 2016

New research opens door to influencing immune system

A new international collaboration involving scientists at The Scripps Research Institute opens a door to influencing the immune system, which would be useful to boost the effectiveness of vaccines or to counter autoimmune diseases such as lupus and rheumatoid arthritis.

2 Aug 2016

Non-functional adrenal tumors can be potential risk factor for type 2 diabetes

Investigators from Brigham and Women's Hospital have found that "non-functional" adrenal tumors can increase a person's risk of developing type 2 diabetes.

2 Aug 2016

Researchers use machine-learning approach to predict autism risk genes

Princeton University and Simons Foundation researchers have developed a machine-learning approach that for the first time analyzes the entire human genome to predict which genes may cause autism spectrum disorder, raising the number of genes that could be linked to the disorder from 65 to 2,500.

1 Aug 2016

Study finds mutations in three new genes can cause rare syndromic CHD disorders

Researchers at The University of Nottingham have been involved in one of the largest international studies of congenital heart disease, which has discovered gene mutations linked to three new rare congenital heart disorders (CHD).

1 Aug 2016

Scientists uncover novel sites of expression in the brain for gene linked to ALS and FTD

For the first time novel expression sites in the brain have been identified for a gene which is associated with Motor Neuron Disease and Frontotemporal Dementia.

1 Aug 2016

Cell-free DNA test could help identify liver transplant patients with acute rejection

Today, researchers presented findings at the 68th AACC Annual Scientific Meeting that DNA found circulating in the bloodstream—known as cell-free DNA—can be used to identify liver transplant patients with acute rejection with greater accuracy than conventional liver function tests.

1 Aug 2016

Study creates comprehensive list of blood biomarkers relevant for early detection of cancer

Researchers have identified 788 biomarkers in blood that could be used to develop an early stage cancer screening test for the general population.

1 Aug 2016

Yale scientists provide new insights into evolutionary origin of female orgasm

Female orgasm seems to be a happy afterthought of our evolutionary past when it helped stimulate ovulation, a new study of mammals shows.

1 Aug 2016

Medical Science News

Scientists develop model using transformed stem cells to accelerate screening of drugs for rare cancers

Preclinical data on Selecta’s novel immune tolerance platform published in Nature Nanotechnology

Researchers shed light on mechanism for inducing memory B cell differentiation

Scientists observe reaction of neurons in real-time after concussive trauma

New review proposes neuroscience-based framework for diagnosis of addictive disorders

Scientists use animal model to gain better understanding of cocaine addiction

GW researchers identify new way to regulate chronic toxoplasmosis

TSRI study unveils new twist in immune biology

Iron-containing catalysts can alter amino acids to help develop new drug candidates

UCI molecular biologists find new way to combat skin cancer

Paternal over-nutrition may lead to generational obesity and metabolic dysfunction

Early initiation of antiretroviral therapy can considerably reduce total HIV DNA levels

New research opens door to influencing immune system

Non-functional adrenal tumors can be potential risk factor for type 2 diabetes

Researchers use machine-learning approach to predict autism risk genes

Study finds mutations in three new genes can cause rare syndromic CHD disorders

Scientists uncover novel sites of expression in the brain for gene linked to ALS and FTD

Cell-free DNA test could help identify liver transplant patients with acute rejection

Study creates comprehensive list of blood biomarkers relevant for early detection of cancer

Yale scientists provide new insights into evolutionary origin of female orgasm

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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