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Decoding the Exposome Through Breath Biomarkers

The human exposome is probably best defined as “everything that is not the genome.” This is a bit tongue in cheek, but basically, the exposome is comprised of all of the chemicals in your body from the environment, food, consumer products, their metabolites, the endogenous “housekeeping” chemicals, the cellular wastes from energy production, as well as all of the messenger compounds and life supporting chemicals.

From Pittcon 24 Feb 2017

Initial diagnosis of acute kidney injury may be inaccurate for many patients, study suggests

Researchers from Columbia University Medical Center have found that, for many patients, an initial diagnosis of "acute kidney injury" may have been inaccurate.

24 Feb 2017

New research offers insights into how differences arise in common illnesses

As much as we try to avoid it, we are constantly sharing germs with those around us. But even when two people have the same infection, the resulting illnesses can be dramatically different--mild for one person, severe or even life-threatening for the other.

24 Feb 2017

NR could potentially prevent chemotherapy-induced peripheral neuropathy in cancer patients

A new study in rats suggests that nicotinamide riboside (NR), a form of vitamin B3, may be useful for treating or preventing nerve pain (neuropathy) caused by chemotherapy drugs.

24 Feb 2017

Computational software that evaluates DNA samples may help in diagnosis, treatment of cancer

A research team from the United States and Canada has developed and successfully tested new computational software that determines whether a human DNA sample includes an epigenetic add-on linked to cancer and other adverse health conditions.

From Oxford Nanopore Technologies 24 Feb 2017

Researchers develop new assay for measuring underlying autoimmunity in rheumatoid arthritis patients

Current treatments for rheumatoid arthritis relieve the inflammation that leads to joint destruction, but the immunologic defect that triggers the inflammation persists to cause relapses, according to research conducted at NYU Langone Medical Center and the University of Pittsburgh.

24 Feb 2017

New test could accelerate development of better treatments for Motor Neuron Disease

A cutting-edge test developed in South Australia has the potential to expedite the worldwide quest to develop better treatments, or even a cure, for the Motor Neuron Disease (MND).

24 Feb 2017

Study reveals promising therapeutic approach that can be beneficial for older melanoma patients

Scientists at The Wistar Institute have shown that an anti-diabetic drug can inhibit the growth of melanoma in older patients by activating an anti-aging gene that in turn inhibits a protein involved in metastatic progression and resistance to targeted therapies for the disease.

24 Feb 2017

Researchers reveal biological pathways involved in diabetic kidney disease

Diabetes is a leading cause of kidney disease, a serious, often fatal complication that is difficult to diagnose in early, potentially treatable stages.

24 Feb 2017

Researchers identify tumour protein that may hold key pancreatic cancer survival

A diagnosis of pancreatic cancer is often a death sentence because current chemotherapies have little impact on the disease.

24 Feb 2017

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

For the first time a "tipping point" molecular link between the blood sugar glucose and Alzheimer's disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer's.

24 Feb 2017

Cutting-edge research into dolphin’s genome could provide solutions to human problems

In movies and TV shows, dolphins are often portrayed as heroes who save humans through remarkable feats of strength and tenacity. Now dolphins could save the day for humans in real life, too - with the help of emerging technology that can measure thousands of proteins and an improved database full of genetic data.

24 Feb 2017

Cocaine use by fathers may negatively impact cognitive development in male offspring

Fathers who use cocaine at the time of conceiving a child may be putting their sons at risk of learning disabilities and memory loss.

24 Feb 2017

BUSM researchers uncover unique patterns of protein synthesis linked to increased longevity

Aging is a complex process that involves multiple metabolic and regulatory pathways. Previous studies have identified hundreds of genes whose deletion can significantly increase lifespan in model organisms. Yet, how these different aging genes and pathways are interconnected remains poorly understood.

23 Feb 2017

Researchers develop new tool that quickly reveals metabolic fluxes in cells

If we were to take photographs at the underground stations in Barcelona, we would see the number of people waiting, find out what time the rush hour takes place and deduce why some stations are busier than others.

23 Feb 2017

Cerebellum can be responsible for brain alterations linked to drug addiction, research shows

An international research team led by the Universitat Jaume I has shown that the cerebellum, contrary to what was thought, fulfils functions that go beyond the motor sphere and can be co-responsible for the brain alterations associated with addictive consumption of drugs.

23 Feb 2017

Alterations in brain connectivity can aid diagnosis and prediction of outcomes in mTBI patients

A new study shows that patients with mild traumatic brain injury, even without evidence of brain lesions, may exhibit changes in brain connectivity detectable at the time of the injury that can aid in diagnosis and predicting the effects on cognitive and behavioral performance at 6 months.

23 Feb 2017

Lack of methyl groups in gene body may lead to emergence of cancer

Every cell in our body contains the complete DNA library. So-called methyl groups regulate that in body tissues only the genetic information is expressed that is indeed needed in this tissue.

23 Feb 2017

New compounds with potent anticancer activity could lessen side effects of oncological treatments

The Universitat Jaume I, the Spanish Centre for Advanced Scientific Research and the University of Pavia have patented new compounds with potent anticancer activity in breast and colon tumour cell lines that have low toxicity in healthy cells, which can dramatically decrease side effects during chemotherapy treatment.

23 Feb 2017

Recommend daily intake of fruit and veg may need doubling, indicates study

Although eating the recommended five portions of fruit and veg a day is good for you, eating ten portions is even better, according to researchers from Imperial College London.

23 Feb 2017

Medical Science News

Decoding the Exposome Through Breath Biomarkers

Initial diagnosis of acute kidney injury may be inaccurate for many patients, study suggests

New research offers insights into how differences arise in common illnesses

NR could potentially prevent chemotherapy-induced peripheral neuropathy in cancer patients

Computational software that evaluates DNA samples may help in diagnosis, treatment of cancer

Researchers develop new assay for measuring underlying autoimmunity in rheumatoid arthritis patients

New test could accelerate development of better treatments for Motor Neuron Disease

Study reveals promising therapeutic approach that can be beneficial for older melanoma patients

Researchers reveal biological pathways involved in diabetic kidney disease

Researchers identify tumour protein that may hold key pancreatic cancer survival

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

Cutting-edge research into dolphin’s genome could provide solutions to human problems

Cocaine use by fathers may negatively impact cognitive development in male offspring

BUSM researchers uncover unique patterns of protein synthesis linked to increased longevity

Researchers develop new tool that quickly reveals metabolic fluxes in cells

Cerebellum can be responsible for brain alterations linked to drug addiction, research shows

Alterations in brain connectivity can aid diagnosis and prediction of outcomes in mTBI patients

Lack of methyl groups in gene body may lead to emergence of cancer

New compounds with potent anticancer activity could lessen side effects of oncological treatments

Recommend daily intake of fruit and veg may need doubling, indicates study

How industrial hygiene flow calibration supports defensible exposure data

How electrical engineering ensures accurate calibration and patient safety

The importance of ketones from a clinical and medical perspective

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