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Metabolic vulnerability in triple-negative breast cancer cells may help quell chemotherapy resistance

A team of researchers led by Alex Toker of the Ludwig Center at Harvard has discovered a metabolic weakness in triple-negative breast cancer cells that may be exploited to quell their resistance to chemotherapy.

2 Mar 2017

Researchers discover CTE in deceased patient's brain with no known history of head trauma

Researchers at Toronto Western Hospital's Canadian Concussion Centre have discovered the presence of chronic traumatic encephalopathy (CTE) in the brain of a deceased patient with no known history of traumatic brain injury or concussion, the first known case of its kind.

2 Mar 2017

City of Hope researchers find how HER2-positive breast cancer patients develop brain metastases

Ninety percent of cancer deaths are from cancer spread. Breast cancer patients, for example, typically do not die because cancer returns in their breast, they die because it spreads to other parts of their body. The most dangerous of which is the brain.

2 Mar 2017

Researcher examines scarring process in hope of preventing chronic lung transplant rejection

For patients affected by lung diseases such as pulmonary fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and others, cures for their diseases are incredibly rare, if not nonexistent.

2 Mar 2017

Innovative gene therapy allows complete remission of clinical signs of sickle cell disease

A team led by Pr. Marina Cavazzana conducted at Necker Children's Hospital, AP-HP and the Imagine Institute in October 2014 gene therapy in the context of a phase I clinical trial / II in a patient 13 years with severe sickle cell disease.

2 Mar 2017

Study provides insights into how cancer cells can evade FGFR inhibitors

A new study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

2 Mar 2017

BUSM researchers participate in five-year program to develop biomarkers for small vessel disease

To better predict, study and diagnose small vessel disease in the brain and its role in vascular contributions to cognitive impairment and dementia (VCID), Boston University School of Medicine has been selected to participate in MarkVCID, a consortium designed to accelerate the development of new and existing biomarkers for small vessel VCID.

2 Mar 2017

Red hair-related gene variant may contribute to link between melanoma and Parkinson's disease

A gene variant that produces red hair and fair skin in humans and in mice, which increases the risk of the dangerous skin cancer melanoma, may also contribute to the known association between melanoma and Parkinson's disease.

2 Mar 2017

Researchers uncover mechanism that contributes to joint inflammation in rheumatoid arthritis patients

New research findings published in the Journal of Leukocyte Biology, suggest that synovial CD4+ T cells that produce IL-21 contribute to joint inflammation by activating synovial fibroblasts in rheumatoid arthritis patients.

2 Mar 2017

Scientists track 'guardian immune cells' to uncover mechanics underlying inflammation and obesity

Scientists have uncovered the physiological mechanics underlying inflammation and obesity by tracking the actions of 'guardian immune cells' in response to changes in diet.

2 Mar 2017

Scientists use molecular bait strategy to capture and isolate cancer-prone protein

Scientists from the Center for Self-assembly and Complexity (CSC) successfully isolated a cancer-prone protein by fishing out the proteins using 'molecular bait'.

2 Mar 2017

Scientists reveal new mRNA method to deliver safe, cost-effective therapeutic antibodies

Using antibodies to treat disease has been one of the great success stories of early 21st-century medicine. Already five of the ten top-selling pharmaceuticals in the United States are antibody products. But antibodies are large, complex proteins that can be expensive to manufacture.

2 Mar 2017

Hydraulic forces aid to fill the heart's chambers with blood, research finds

Researchers at Karolinska Institutet and KTH Royal Institute of Technology in Sweden have contributed to a recent discovery that the heart is filled with the aid of hydraulic forces, the same as those involved in hydraulic brakes in cars.

2 Mar 2017

New test reveals the truth about how much urine is in swimming pools

Scientists have designed a new way of testing the amount of urine present in swimming pools, according to a Canadian study.

2 Mar 2017

Cigarette smoke blocks lung's self-healing that can lead to COPD

Smoke from cigarettes blocks self-healing processes in the lungs and consequently can lead to chronic obstructive pulmonary disease (COPD).

2 Mar 2017

Study establishes ENL protein as potential drug target for acute myeloid leukemia

Anyone who uses an employee badge to enter a building may understand how a protein called ENL opens new possibilities for treating acute myeloid leukemia (AML), a fast-growing cancer of bone marrow and blood cells and the second most common type of leukemia in children and adults.

2 Mar 2017

Medical Science News

Metabolic vulnerability in triple-negative breast cancer cells may help quell chemotherapy resistance

Researchers discover CTE in deceased patient's brain with no known history of head trauma

City of Hope researchers find how HER2-positive breast cancer patients develop brain metastases

Researcher examines scarring process in hope of preventing chronic lung transplant rejection

Innovative gene therapy allows complete remission of clinical signs of sickle cell disease

Study provides insights into how cancer cells can evade FGFR inhibitors

BUSM researchers participate in five-year program to develop biomarkers for small vessel disease

Red hair-related gene variant may contribute to link between melanoma and Parkinson's disease

Researchers uncover mechanism that contributes to joint inflammation in rheumatoid arthritis patients

Scientists track 'guardian immune cells' to uncover mechanics underlying inflammation and obesity

Scientists use molecular bait strategy to capture and isolate cancer-prone protein

Scientists reveal new mRNA method to deliver safe, cost-effective therapeutic antibodies

Hydraulic forces aid to fill the heart's chambers with blood, research finds

New test reveals the truth about how much urine is in swimming pools

Cigarette smoke blocks lung's self-healing that can lead to COPD

Study establishes ENL protein as potential drug target for acute myeloid leukemia

Newly-identified autoimmune endocrine disease is caused by thymomas, study finds

Gut bacteria impact intestinal and behavioural symptoms in IBS patients, study finds

Cholesterol-processing enzyme could be therapeutic target to stave off neurologic diseases

Researchers looking at ways to target lingering cancer stem cells that cause disease relapse

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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