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Study reveals pathways behind organ damage in severe COVID-19

New research published in the journal Proceedings of the National Academy of Sciences sheds light on the pathways that drive organ damage and death in severe COVID-19 and helps explain why survivors of the disease can experience long-term complications.

2 Dec 2024

Large language models could help automate functional genomics research

Researchers at University of California San Diego School of Medicine have demonstrated that large language models (LLMs), such as GPT-4, could help automate functional genomics research, which seeks to determine what genes do and how they interact.

2 Dec 2024

New insights into how aging affects muscle cell regeneration

As muscles age, their cells lose the ability to regenerate and heal after injury. Now, Cornell University researchers have created the most comprehensive portrait to date of how that change, in mice, unfolds over time.

2 Dec 2024

Hypothalamic deep brain stimulation restores walking after spinal cord injury

Scientists have identified neurons in the lateral hypothalamus that can be targeted through deep brain stimulation to improve walking after spinal cord injury (SCI). This innovative approach shows promise in both animal models and initial human trials, paving the way for groundbreaking treatments.

2 Dec 2024

Researchers develop organoid mimicking human fetal pancreas

Researchers from the Organoid group (previously Clevers group) at the Hubrecht Institute have developed a new organoid that mimics the human fetal pancreas, offering a clearer view of its early development.

2 Dec 2024

Great ape museum specimens reveal secrets of DNA virus evolution

Scientists screened great ape museum specimens for DNA viruses, revealing insights into viral evolution and host-virus associations spanning decades.

2 Dec 2024

Study reveals how stem cells sense and respond to their environment

A new study from The Hospital for Sick Children (SickKids) and Institut Curie reveals how stem cells sense and respond to their environment, with implications for inflammatory bowel disease and colorectal cancer.

2 Dec 2024

Spatial transcriptomics uncovers new treatment paths for triple-negative breast cancer

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative breast cancer (TNBC). The findings identify nine spatial archetypes and gene signatures linked to immunotherapy response and patient outcomes.

2 Dec 2024

Researchers discover new cause of cytokine storm in COVID-19

As part of the COVID-19 International Research Team, researchers at the Johns Hopkins Kimmel Cancer Center, Children's Hospital of Philadelphia, the University of Pittsburgh and Weill Cornell Medicine discovered a novel cause of cytokine storm - the extreme inflammatory response associated with increased risk of death in COVID-19 infection.

2 Dec 2024

Alcohol consumption raises pain threshold and aggressive behavior

Alcohol's ability to increase people's pain threshold is one reason that drinking also leads to more aggressive behavior, a new study suggests.

2 Dec 2024

Study highlights the critical role of TLR7 in sex-biased Alzheimer’s-related demyelination

Inhibiting an immune signaling protein called TLR7 may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer's disease and ordinary aging, suggests a study led by researchers at Weill Cornell Medicine.

2 Dec 2024

Boosting endocannabinoids could reduce opioid addiction risk

Increasing the levels of chemicals naturally produced in the body called endocannabinoids may thwart the highly addictive nature of opioids such as morphine and oxycodone while maintaining the drugs' ability to relieve pain, according to Weill Cornell Medicine investigators working with researchers from The Center for Youth Mental Health at NewYork-Presbyterian.

2 Dec 2024