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Study explores role of genetic and environmental factors in development of social anxiety

Genes play a crucial role over time although environmental factors matter most in the short term, according to a major study into social anxiety and avoidant personality disorders from the Norwegian Institute of Public Health.

21 Jan 2016

Scientists solve atomic structure of ubiquitin ligase complex that plays key role in protein degradation

Scientists at Sanford Burnham Prebys Medical Discovery Institute have solved the atomic structure of a unique ubiquitin ligase complex. Ubiquitin is best known for its role in protein degradation, but more recently seen as important for cell signaling, DNA repair, anti-inflammatory, and immune responses.

21 Jan 2016

Northwestern researchers use fruit fly genetics to understand how things may go wrong in cancer

Cancer cells are normal cells that go awry by making bad developmental decisions during their lives. In a study involving the fruit fly equivalent of an oncogene implicated in many human leukemias, Northwestern University researchers have gained insight into how developing cells normally switch to a restricted, or specialized, state and how that process might go wrong in cancer.

21 Jan 2016

High-traffic 'hub neurons' may play role in understanding brain health

Just as most of the world's air travel passes through a few major hubs, the majority of information in the brain flows through similarly well-traveled routes, Indiana University scientists have found.

21 Jan 2016

Berlin researchers identify defects in myotubular myopathy

Tiny deviations in the body's cells can sometimes have severe consequences. Researchers from Berlin have discovered why cells from patients suffering from the rare muscular disease myotubular myopathy cannot function properly.

21 Jan 2016

Gene therapy holds considerable potential for safe, effective treatment of people with factor VII deficiency

Hematology researchers have used a single injection of gene therapy to correct a rare bleeding disorder, factor VII deficiency, in dogs. This success in large animals holds considerable potential for a safe, effective and long-lasting new treatment in humans with the same bleeding disorder.

21 Jan 2016

Study provides better understanding of familial risk for depression

Building on a 30-year, three-generation study of depressed individuals, their children and offspring, a study published in the journal Psychiatry Research: Neuroimaging provides a better understanding of the familial risk for depression and the role neuroplasticity might have in increasing the risk of developing depression.

21 Jan 2016

Study provides evidence for use of inherited genetic markers to improve melanoma prognostication

Melanoma is the most dangerous and lethal form of skin cancer. But just how long will a patient survive following the removal of a melanoma tumor? A more definitive answer to that question could come from new studies at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center. Researchers there have discovered an inherited genetic marker that might provide clinicians with a personalized tool to gauge an individual's survival and determine which patients require closer monitoring in the years following surgery.

21 Jan 2016

Discovery may help researchers identify new ways to attack malaria parasite

New anti-malarial drugs could be developed after researchers discovered a new mechanism used by the malaria parasite when it infects humans.

21 Jan 2016

UC Berkeley researchers make major improvement in CRISPR-Cas9 gene editing technology

University of California, Berkeley, researchers have made a major improvement in CRISPR-Cas9 technology that achieves an unprecedented success rate of 60 percent when replacing a short stretch of DNA with another.

21 Jan 2016

Anxiety can make people to walk in a leftward trajectory

People experiencing anxiety and inhibition have more activity in the right side of the brain, causing them to walk in a leftward trajectory.

20 Jan 2016

Study outlines new model to help predict age-related response to hepatitis B vaccine

Physicians have known for years that patients respond differently to vaccines as they age. There may soon be a new way to predict and enhance the effectiveness of vaccinations, in particular the hepatitis B vaccine.

20 Jan 2016

Novel gene therapy treatment proves safe, effective for factor VII deficiency

A single injection. That's all someone with a factor VII deficiency would need for a life-long cure, thanks to a new gene therapy treatment developed in a collaboration of researchers at the University of North Carolina and The Children's Hospital of Philadelphia.

20 Jan 2016

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

Scientists have identified a gene that appears to play a significant role in raising a person's risk of having more severe subtypes of autism that co-occur with other genetic diseases, such as the chromosomal disorder 22q11.2 deletion syndrome.

20 Jan 2016

Low levels of cortisol in bipolar patients associated with depression, obesity and metabolic syndrome

New observations show that older bipolar patients often have decreased activity in the hormone system responsible for the secretion of the stress hormone cortisol. Low levels of cortisol in bipolar patients were also associated with depression, low quality of life, obesity, dyslipidaemia and metabolic syndrome.

20 Jan 2016

Researchers reconstruct 3D images of protein structures that link heart muscle cells in working groups

Diseased hearts may be thrown out of rhythm by structural differences -- now visible for the first time -- in protein groups that connect heart muscle cells, according to the authors of a study to be published in the journal Nature Communications online Jan. 20.

20 Jan 2016

Amorphous iron nanoparticles have potential to kill tumor cells

Amorphous iron nanoparticles have a specific toxicity in tumor cells. In the journal Angewandte Chemie, Chinese scientists describe their design and synthesis of a special amorphous state of nanoparticulate iron, which can locally release reactive iron species in the acidic and hydrogen peroxide rich environment of cancer cells, providing new possibilities for theranostics and chemodynamic therapies.

20 Jan 2016

Scientists reveal why non-alcoholic steatohepatitis worsens in obese people

In results published on October 19, 2015 in the Journal of Lipid Research, a team of translational scientists at the Medical University of South Carolina report a new reason why non-alcoholic steatohepatitis (NASH) worsens in people who are obese.

20 Jan 2016

Neuroscientists identify the brain network system that causes people to slip when anxious

As musicians, figure skaters and anyone who takes a driving test will know, the anxiety of being watched can have a disastrous effect on your performance. Now neuroscientists at the University of Sussex's Sackler Centre and Brighton and Sussex Medical School have identified the brain network system that causes us to stumble and stall just when we least want to.

20 Jan 2016

New Georgia Tech research center launched to manufacture living cells for cell-based therapies

A $15.7 million grant from the Atlanta-based Marcus Foundation has helped launch a new Georgia Institute of Technology research center that will develop processes and techniques for ensuring the consistent, low-cost, large-scale manufacture of high-quality living cells used in cell-based therapies.

20 Jan 2016

Medical Science News

Study explores role of genetic and environmental factors in development of social anxiety

Scientists solve atomic structure of ubiquitin ligase complex that plays key role in protein degradation

Northwestern researchers use fruit fly genetics to understand how things may go wrong in cancer

High-traffic 'hub neurons' may play role in understanding brain health

Berlin researchers identify defects in myotubular myopathy

Gene therapy holds considerable potential for safe, effective treatment of people with factor VII deficiency

Study provides better understanding of familial risk for depression

Study provides evidence for use of inherited genetic markers to improve melanoma prognostication

Discovery may help researchers identify new ways to attack malaria parasite

UC Berkeley researchers make major improvement in CRISPR-Cas9 gene editing technology

Anxiety can make people to walk in a leftward trajectory

Study outlines new model to help predict age-related response to hepatitis B vaccine

Novel gene therapy treatment proves safe, effective for factor VII deficiency

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

Low levels of cortisol in bipolar patients associated with depression, obesity and metabolic syndrome

Researchers reconstruct 3D images of protein structures that link heart muscle cells in working groups

Amorphous iron nanoparticles have potential to kill tumor cells

Scientists reveal why non-alcoholic steatohepatitis worsens in obese people

Neuroscientists identify the brain network system that causes people to slip when anxious

New Georgia Tech research center launched to manufacture living cells for cell-based therapies

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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