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Researchers develop effective technique for studying high-arched palate using mouse model

Researchers from the laboratory of Paul Trainor, Ph.D., at the Stowers Institute of Medical Research have developed an effective and reliable technique for studying high-arched palate using a mouse model. The methodology could expand research into the genetic aspects of this craniofacial abnormality.

27 Feb 2016

TTR protein causes autoimmune reaction in joints of juvenile idiopathic arthritis patients

Juvenile idiopathic arthritis, or JIA, is the most common form of childhood arthritis. It appears to be an autoimmune disease, caused by antibodies attacking certain proteins in a person's own tissue. But no "autoantigens" -- the proteins triggering an immune attack -- have been linked to JIA.

27 Feb 2016

New drug shows promise against Huntington's disease

A drug that would be the first to target the cause of Huntington's disease (HD) is effective and safe when tested in mice and monkeys, according to data released today that will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016.

27 Feb 2016

Major breakthrough opens door to better understanding of molecular mechanisms of pancreatic cancer

Pancreatic cancer carries a very bleak prognosis for patients. However, a recent breakthrough by two research teams, including one at the Hôpital Maisonneuve-Rosemont (CIUSSS-EST, Montreal) and University of Montreal, has opened the door to a better understanding of the molecular mechanisms that cause this cancer to develop.

26 Feb 2016

Researchers map cellular pathway that may lead to treatments for obesity, diabetes

Control over obesity and diabetes may be one step closer thanks to a Hiroshima University study in fat tissue.

26 Feb 2016

New analytical tool may help diagnose cancer faster than conventional methods

Researchers have developed a new analytical tool for medical applications and biological research that might be used to diagnose cancer more rapidly than conventional methods.

26 Feb 2016

Protein p62 acts as molecular brake to keep inflammation in check, avoid collateral damage

Inflammation is a Catch-22: the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and sometimes leading to organ failure and death. Researchers at University of California, San Diego School of Medicine have discovered that a protein known as p62 acts as a molecular brake to keep inflammation in check and avoid collateral damage.

26 Feb 2016

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Life-threatening heart damage is an adverse side effect of the cancer drug doxorubicin, damage that also limits the use of newer chemotherapeutic agents such as trastuzumab and imatinib. The ability to protect the heart from these side effects would benefit patients, including cancer survivors who are at risk of developing heart damage years later, and it also could allow safer use of these drugs at higher doses.

26 Feb 2016

Genome sequencing shows association between STIs and Trachoma

For the first time, genome sequencing has been carried out on Chlamydia trachomatis (C. trachomatis), a bacteria responsible for the disease Trachoma - the world's leading infectious cause of blindness, according to a study in Nature Communications.

26 Feb 2016

Japanese bioengineers tweak E. coli genes to pump out morphine precursor

A common gut microbe could soon be offering us pain relief. Japanese bioengineers have tweaked Escherichia coli genes so that they pump out thebaine, a morphine precursor that can be modified to make painkillers. The genetically modified E. coli produces 300 times more thebaine with minimal risk of unregulated use compared to a recently developed method involving yeast.

26 Feb 2016

Research finding could lay foundation for more accurate diagnosis for rare childhood brain tumor

An international research team has identified four likely new subtypes of a rare brain tumor using molecular techniques that lay the foundation for more accurate diagnosis and tailored therapies for the hard-to-treat cancer. Scientists at St. Jude Children's Research Hospital and the German Cancer Research Center led the study, results of which appear today in the scientific journal Cell.

26 Feb 2016

Medical community has unique role to play in determining future use of mitochondrial replacement techniques

There is a unique role for the United States medical community to play in determining the future application of, and ethically acceptable approach to, mitochondrial replacement techniques (MRTs), according to a commentary published online by the New England Journal of Medicine.

26 Feb 2016

Aggregated forms of transthyretin can trigger JIA development

Juvenile idiopathic arthritis (JIA) is a the most common form of arthritis in children and affects approximately 50,000 individuals in the United States alone. Previous research suggested that autoimmune responses cause JIA, but the specific antigens that are responsible for driving autoimmunity have not been identified.

26 Feb 2016

Scientists develop new optical technique to observe neurotransmitter activity of individual synapses

Columbia University scientists have developed a new optical technique to study how information is transmitted in the brains of mice. Using this method, they found that only a small portion of synapses -- the connections between cells that control brain activity--may be active at any given time.

26 Feb 2016

Clinical validation study on MaterniT GENOME test published in American Journal of Obstetrics and Gynecology

Sequenom, Inc., a life sciences company committed to enabling healthier lives through the development of innovative products and services, today announced the publication of a clinical validation study on the MaterniT GENOME laboratory-developed test in the American Journal of Obstetrics and Gynecology.

26 Feb 2016

Moffitt researchers develop novel therapeutic strategy to keep resistant cells in check

Despite numerous advances in oncology since the War on Cancer began, many patients develop resistance to standard therapies and eventually relapse. Moffitt Cancer Center researchers hope to improve treatment outcomes with development of a novel therapeutic strategy, called adaptive therapy, which is based on evolutionary principals and aims to keep resistant cells in check by maintaining a population of chemo-sensitive cells.

25 Feb 2016

Pancreatic cancer identified as four separate diseases with different genetic triggers, survival rates

An international team led by Australian researchers has studied the genetics of pancreatic cancer, revealing it is actually four separate diseases, each with different genetic triggers and survival rates, paving the way for more accurate diagnoses and treatments.

25 Feb 2016

UNC-Chapel Hill pharmacy researchers use skin cells to destroy brain tumors

In a first for medical science, University of North Carolina at Chapel Hill pharmacy researchers turn skin cells into cancer-hunting stem cells that destroy brain tumors known as glioblastoma - a discovery that can offer, for the first time in more than 30 years, a new and more effective treatment for the disease.

25 Feb 2016

New study allows researchers to see how insulin in islets responds to sugar

"Scientists and doctors have wanted to know how much insulin a person has in their body, but haven't been able to know the exact amount without the patient being deceased and actually removing the pancreas," says Peter Arvan, division chief of Metabolism, Endocrinology & Diabetes at the University of Michigan.

25 Feb 2016

Study provides pathways to understand complex neurological disorders

Scientists have now described the engineering of a bright red fluorescent protein-based voltage indicator, providing pathways to understanding complex neurological disorders. Designated as FlicR1 (fluorescent indicator for voltage imaging red), these indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution.

25 Feb 2016

Medical Science News

Researchers develop effective technique for studying high-arched palate using mouse model

TTR protein causes autoimmune reaction in joints of juvenile idiopathic arthritis patients

New drug shows promise against Huntington's disease

Major breakthrough opens door to better understanding of molecular mechanisms of pancreatic cancer

Researchers map cellular pathway that may lead to treatments for obesity, diabetes

New analytical tool may help diagnose cancer faster than conventional methods

Protein p62 acts as molecular brake to keep inflammation in check, avoid collateral damage

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Genome sequencing shows association between STIs and Trachoma

Japanese bioengineers tweak E. coli genes to pump out morphine precursor

Research finding could lay foundation for more accurate diagnosis for rare childhood brain tumor

Medical community has unique role to play in determining future use of mitochondrial replacement techniques

Aggregated forms of transthyretin can trigger JIA development

Scientists develop new optical technique to observe neurotransmitter activity of individual synapses

Clinical validation study on MaterniT GENOME test published in American Journal of Obstetrics and Gynecology

Moffitt researchers develop novel therapeutic strategy to keep resistant cells in check

Pancreatic cancer identified as four separate diseases with different genetic triggers, survival rates

UNC-Chapel Hill pharmacy researchers use skin cells to destroy brain tumors

New study allows researchers to see how insulin in islets responds to sugar

Study provides pathways to understand complex neurological disorders

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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