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Computer simulations shed light on dynamic structure of major target for anti-cancer drugs

Using advanced computer simulations, University of Utah College of Pharmacy researchers have produced moving images of a protein complex that is an important target for anti-cancer drugs.

18 Aug 2012

Increasing blood levels of particular proteins may act as warning signs for IgA nephropathy

Increasing blood levels of particular proteins may act as warning signs for patients with one of the most common diseases of the kidney, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

17 Aug 2012

Pyruvate kinase M2 fuels tumor growth by influencing H3 histone protein

A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson Cancer Center reports in the Aug. 16 issue of Cell.

17 Aug 2012

Dendritic cells protect against MS in mouse model

In multiple sclerosis, the immune system attacks nerves in the brain and spinal cord, causing movement problems, muscle weakness and loss of vision. Immune cells called dendritic cells, which were previously thought to contribute to the onset and development of multiple sclerosis, actually protect against the disease in a mouse model, according to a study published by Cell Press in the August issue of the journal Immunity.

17 Aug 2012

Peptide combinations might offer more effective cancer therapy

Two studies suggest that two peptide agents used either together or individually with a low-dose of a standard chemotherapy drug might offer more effective cancer therapy than current standard single-drug treatments.

17 Aug 2012

Damage to the ventromedial prefrontal cortex increases credulity

Everyone knows the adage: "If something sounds too good to be true, then it probably is." Why, then, do some people fall for scams and why are older folks especially prone to being duped? An answer, it seems, is because a specific area of the brain has deteriorated or is damaged, according to researchers at the University of Iowa.

17 Aug 2012

Researchers develop multi-dimensional MRI method to assess age in children

A national team of researchers led by investigators at the University of California, San Diego School of Medicine have developed a multidimensional set of brain measurements that, when taken together, can accurately assess a child's age with 92 percent accuracy.

17 Aug 2012

Study helps explain how large DNA viruses undergo rapid evolution

Scientists have discovered that poxviruses, which are responsible for smallpox and other diseases, can adapt to defeat different host antiviral defenses by quickly and temporarily producing multiple copies of a gene that helps the viruses to counter host immunity.

17 Aug 2012

New DNA sequencing tests improve ability to analyze genetic disorders

Scientists at the University of Medicine and Dentistry of New Jersey-New Jersey Medical School (UMDNJ-NJMS) have developed new DNA sequencing tests that hold significant promise for decreasing costs associated with diagnosing cancer and hereditary diseases, including cysticfibrosis.

17 Aug 2012

Curcumin shows promise in fighting devastating viruses

The popular spice turmeric packs more than just flavor - it shows promise in fighting devastating viruses, Mason researchers recently discovered.

17 Aug 2012

Pan-fried red meat associated with increased risk of advanced prostate cancer

Research from the University of Southern California (USC) and Cancer Prevention Institute of California (CPIC) found that cooking red meats at high temperatures, especially pan-fried red meats, may increase the risk of advanced prostate cancer by as much as 40 percent.

17 Aug 2012

Researchers identify molecular and protein signatures that predict HCV virus-induced liver injury

Researchers have discovered molecular and protein signatures that predict rapid onset of liver damage in hepatitis C patients following a liver transplant. The markers appeared soon after transplant and well before clinical evidence of liver damage.

17 Aug 2012

Researchers use small molecule compound to generate reversible birth control in male mice

The development of a male contraceptive pill has long proven to be elusive, but findings from a new study may point scientists in the right direction to making oral birth control for men a reality.

17 Aug 2012

Study reveals why human brain is large and more complex than that of other animals

Researchers have found what they believe is the key to understanding why the human brain is larger and more complex than that of other animals.

17 Aug 2012

Walnuts provide key nutrients that may be essential in male reproductive health

Research published in the recent issue of Biology of Reproduction Papers-in-Press reports that 75 grams (approximately 2.5 ounces) of walnuts consumed per day improved sperm vitality, motility, and morphology (normal forms) in a group of healthy young men between 21-35 years of age.

17 Aug 2012

T. gondii can cause inflammation in the brain

A parasite thought to be harmless and found in many people may actually be causing subtle changes in the brain, leading to suicide attempts.

17 Aug 2012

PKS-positive E. coli may encourage development of colon cancer

Scientists at the University of Liverpool have identified a type of E. coli bacteria that may encourage the development of colon cancer.

17 Aug 2012

Plexin B2-CD100 interaction for prompt activation of γδ T cells and wound healing

Scientists at The Scripps Research Institute have made a breakthrough in understanding a class of cells that help wounds in skin and other epithelial tissues heal, uncovering a molecular mechanism that pushes the body into wound-repair mode.

17 Aug 2012

Sophisticated brain scans can accurately predict age

It isn't uncommon for people to pass for ages much older or younger than their years, but researchers have now found that this feature doesn't apply to our brains. The findings reported online on August 16 in Current Biology, a Cell Press publication, show that sophisticated brain scans can be used to accurately predict age, give or take a year.

17 Aug 2012