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Mathematics of sleep-wake cycle

Why can't I fall asleep? Will this new medication keep me up all night? Can I sleep off this cold? Despite decades of research, answers to these basic questions about one of our most essential bodily functions remain exceptionally difficult to answer. In fact, researchers still don't fully understand why we even sleep at all. In an effort to better understand the sleep-wake cycle and how it can go awry, researchers at Rensselaer Polytechnic Institute are taking a different approach than the traditional brain scans and sleep studies. They are using mathematics.

26 Feb 2010

Regulus Therapeutics, GSK announce new collaboration on microRNA therapeutics targeting microRNA-122

Regulus Therapeutics Inc. today announced the establishment of a new collaboration with GlaxoSmithKline (GSK) to develop and commercialize microRNA therapeutics targeting microRNA-122 in all fields with Hepatitis C Viral infection (HCV) as the lead indication. Under the terms of the new collaboration, Regulus will receive additional upfront and early-stage milestone payments with the potential to earn more than $150 million in miR-122-related combined payments, and tiered royalties up to double digits on worldwide sales of products.

25 Feb 2010

"Hope – It's In Our Genes" rare disease campaign slogan translated into multiple international languages and Braille

The Global Genes Project (www.globalgenesproject.org), today announced that its rare disease campaign slogan, "Hope – It's In Our Genes™," has been translated into multiple international languages and Braille by rare disease patient advocates and supporters from around the world. The translation of this slogan unifies the rare disease community and global network under one banner.

25 Feb 2010

Semafore Pharmaceuticals awarded U.S. patent covering PI-3 kinase inhibitor prodrugs

Semafore Pharmaceuticals today announced today announced the United States Patent and Trademark Office (PTO) has issued United States Patent Number 7,662,977 entitled “PI-3 Kinase Inhibitor Prodrugs.” This composition of matter patent covers a genus of novel compounds that includes SF1126, Semafore’s clinical stage, small molecule inhibitor of phosphoinositide-3-kinase (PI3K) and mammalian target of rapamycin (mTOR), two key members of the PI3K signaling pathway that is vital to several essential biological processes, such as cell proliferation and survival.

25 Feb 2010

Elsevier introduces new online book series for scientific community

Elsevier, a world-leading publisher of scientific, technical, and medical information products and services, announced today the launch of Elsevier Insights, a new online book series covering topics in areas such as life and physical sciences, engineering, computer science, tourism, and finance.

25 Feb 2010

Lab research targets 'estrogen-receptor positive' breast cancer cells; identifies key protein

In a laboratory study published in the journal Cancer Research, Scott & White Healthcare anatomic pathologist Arundhati Rao, M.D. is a co-investigator looking at the ways in which estrogen can interfere with how chemotherapy does its job in destroying breast cancer cells.

25 Feb 2010

LGL awards first three grants from POC fund for research in immunotherapy, schizophrenia and heart disease

London Genetics Limited, an expert in the use of pharmacogenetics in clinical drug discovery and development, has awarded the first three grants from its proof-of-concept (POC) fund. The awards, to teams at Imperial College London and University College London, are for research in the areas of immunotherapy, schizophrenia and heart disease.

25 Feb 2010

Recovery of consciousness in traumatic brain injury patients

The recovery of consciousness following traumatic brain injury and recent advances in neuroimaging and deep brain stimulation will be discussed at the 14th Annual Swartz Foundation Mind/Brain Lecture at Stony Brook University on Monday, March 15, 2010 at 4:30 p.m. in the Staller Center for the Arts.

25 Feb 2010

Agilent Technologies announces new multiplexing capability in SureSelect Target Enrichment System

Agilent Technologies Inc. today announced that its Agilent SureSelect Target Enrichment System supports multiplexed DNA sequencing of 12 to 16 samples per lane depending on the next-generation sequencing platform, reducing costs and increasing throughput up to 16-fold.

25 Feb 2010

NIPTRC and partners announce development of new imaging process for proton beam therapy in cancer

Scientists and researchers from the Northern Illinois Proton Treatment and Research Center (NIPTRC) and Northern Illinois University along with their partners are developing a new imaging process using a proton beam that they believe will be a major medical breakthrough in the delivery of proton beam therapy for cancer patients.

25 Feb 2010

Hormone vasopressin helps brain differentiate between familiar and new scents

The study, published in the journal Nature, suggests that when the hormone fails to function, animals are unable to recognise other individuals from their scent.

25 Feb 2010

α-defensins1-3 may be potential prophylactic agents in treatment of HIV / AIDS

HIV/AIDS remains one of the world's most significant public health challenges, particularly in developing countries. The Human Immunodeficiency Virus (HIV-1), the variant responsible for the pandemic, has the ability to infect different cell types such as T cells, macrophages and dendritic cells (DC). These latter cells are crucial in the defense against infectious agents and play a major role in viral pathogenesis.

25 Feb 2010

Platelet function tests may predict heart attack, says study

An analysis of six tests that are used to measure platelet function and help gauge the effectiveness of antiplatelet drugs for patients undergoing a cardiac procedure such as a coronary stent implantation found that only three of the tests were associated with a modest ability to predict outcomes such as heart attack or death, according to a study in the February 24 issue of JAMA.

25 Feb 2010

Signaling molecules may link certain actions of B cells to solid tumor growth: Study

Cancer researchers studying the immune system have identified a previously unrecognized set of targets and biomarkers to battle solid tumors.

25 Feb 2010

Transplanting genetically modified adult stem cells into injured spinal cord increases movement recovery

Researchers at UTHealth have demonstrated in rats that transplanting genetically modified adult stem cells into an injured spinal cord can help restore the electrical pathways associated with movement. The results are published in the Feb. 24 issue of the Journal of Neuroscience.

25 Feb 2010

Neutron scattering could play a key role in curbing HIV and global warming

Subatomic particles called neutrons are poised to play a big role in fighting HIV, slowing global warming, and improving manufacturing processes.

25 Feb 2010

Retinitis Pigmentosa: Embryonic stem cells for replacement of diseased retinal cells and restoration of sight

An international research team led by Columbia University Medical Center successfully used mouse embryonic stem cells to replace diseased retinal cells and restore sight in a mouse model of retinitis pigmentosa. This strategy could potentially become a new treatment for retinitis pigmentosa, a leading cause of blindness that affects approximately one in 3,000 to 4,000 people, or 1.5 million people worldwide.

25 Feb 2010

SeqWright deploys Isilon scale-out NAS storage solution for next-generation genomic sequencing services

Isilon® Systems today announced that SeqWright has deployed Isilon scale-out NAS as an end-to-end storage solution for its full range of next-generation genomic sequencing services. By combining Isilon's X-Series, NL-Series and Backup Accelerator, SeqWright has created a comprehensive solution for every stage of its DNA sequencing workflow – from primary storage, to nearline archival, to tape backup – accelerating time-to-results without requiring full-time storage administration.

25 Feb 2010

Brain implant helps scientists in determining link between brainwave patterns and attention

A paralyzed patient implanted with a brain-computer interface device has allowed scientists to determine the relationship between brain waves and attention.

25 Feb 2010

Rapamycin may hold promise for Alzheimer's disease

Rapamycin, a drug that keeps the immune system from attacking transplanted organs, may have another exciting use: fighting Alzheimer's disease.

25 Feb 2010

Medical Science News

Mathematics of sleep-wake cycle

Regulus Therapeutics, GSK announce new collaboration on microRNA therapeutics targeting microRNA-122

"Hope – It's In Our Genes" rare disease campaign slogan translated into multiple international languages and Braille

Semafore Pharmaceuticals awarded U.S. patent covering PI-3 kinase inhibitor prodrugs

Elsevier introduces new online book series for scientific community

Lab research targets 'estrogen-receptor positive' breast cancer cells; identifies key protein

LGL awards first three grants from POC fund for research in immunotherapy, schizophrenia and heart disease

Recovery of consciousness in traumatic brain injury patients

Agilent Technologies announces new multiplexing capability in SureSelect Target Enrichment System

NIPTRC and partners announce development of new imaging process for proton beam therapy in cancer

Hormone vasopressin helps brain differentiate between familiar and new scents

α-defensins1-3 may be potential prophylactic agents in treatment of HIV / AIDS

Platelet function tests may predict heart attack, says study

Signaling molecules may link certain actions of B cells to solid tumor growth: Study

Transplanting genetically modified adult stem cells into injured spinal cord increases movement recovery

Neutron scattering could play a key role in curbing HIV and global warming

Retinitis Pigmentosa: Embryonic stem cells for replacement of diseased retinal cells and restoration of sight

SeqWright deploys Isilon scale-out NAS storage solution for next-generation genomic sequencing services

Brain implant helps scientists in determining link between brainwave patterns and attention

Rapamycin may hold promise for Alzheimer's disease

Reducing polypharmacy through innovative drug formulation technologies

How innovation in dried blood spot testing is transforming neurological disease monitoring

Unlocking live single-cell functional insights

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