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Artificial liver for drug tests

If you have hay fever, headaches or a cold, it's only a short way to the nearest chemist. The drugs, on the other hand, can take eight to ten years to develop.

25 Jun 2009

New protein stabilisation technique could revolutionise therapeutic drug discovery

A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) which could lead to 30 per cent more proteins being available as potential targets for drug development - opening up exciting possibilities in drug discovery.

25 Jun 2009

Protein biochips

Biochips carrying thousands of DNA fragments are widely used for examining genetic material. Experts would also like to have biochips on which proteins are anchored. This requires a gel layer which can now be produced industrially.

24 Jun 2009

Scientists unearth the roots of human genetic variation

A new study at the University of Leicester is using advanced single molecule methods to explore processes that lie at the very core of DNA variation in humans.

23 Jun 2009

Backtracking and proofreading in DNA transcription

Accuracy is essential for life, so in converting the information stored in DNA into a form in which it can be used, a high level of precision is required. Dr Tanniemola Liverpool from the University of Bristol Department of Mathematics, working with colleagues from the University of Leeds, has developed a mathematical model for how the required accuracy is achieved.

23 Jun 2009

DNA template could explain evolutionary shifts

Rearrangements of all sizes in genomes, genes and exons can result from a glitch in DNA copying that occurs when the process stalls at a critical point and then shifts to a different genetic template, duplicating and even triplicating genes or just shuffling or deleting part of the code within them, said researchers from Baylor College of Medicine in a recent report in the journal Nature Genetics.

22 Jun 2009

Goby fish may bring new drugs for high blood pressure

Medical scientists at the University of Leicester are investigating how a species of fish from the Pacific Ocean could help provide answers to tackling chronic conditions such as hereditary high blood pressure and kidney disease.

22 Jun 2009

Rapid prototyping of new tissues and organs

A more effective way to build plastic scaffolds on which new tissues and even whole organs might be grown in the laboratory is being developed by an international collaboration between teams in Portugal and the UK.

18 Jun 2009

Novel light-sensitive compounds show promise for photodynamic cancer therapy

Chemists at the University of California, Santa Cruz, have developed novel compounds that show promise for photodynamic cancer therapy, which uses light-activated drugs to kill tumor cells.

17 Jun 2009

Chitosan and polyester ‘combo’ creates mixed-fiber material for nerve repair

In the clothing industry it's common to mix natural and synthetic fibers. Take cotton and add polyester to make clothing that's soft, breathable and wrinkle free.

17 Jun 2009

Bio-friendly nanocrystals allow study of biomolecules one at a time

Researchers at the U.S. Department of Energy's (DOE) Lawrence Berkeley National Laboratory have created bright, stable and bio-friendly nanocrystals that act as individual investigators of activity within a cell.

17 Jun 2009

Taxol-carrying nanoparticles

Nanoparticles specially engineered by University of Central Florida Assistant Professor J. Manuel Perez and his colleagues could someday target and destroy tumors, sparing patients from toxic, whole-body chemotherapies.

17 Jun 2009

Enzyme TFIIH kinase found to be involved in epigenetic regulation

For many years scientists have known that the numerous biological functions of an organism are not regulated solely by the DNA sequence of its genes: Superordinate regulatory mechanisms exist that contribute to determining the fate of genes. Although they are not anchored in the DNA, they can even be passed on to subsequent generations to a certain extent. Intensive research in recent years has shown that these mechanisms - bundled under the term epigenetics, are very multifaceted and complex.

17 Jun 2009

Plant microbe shares features with drug-resistant pathogen - implications for biotech

An international team of scientists has discovered extensive similarities between a strain of bacteria commonly associated with plants and one increasingly linked to opportunistic infections in hospital patients. The findings suggest caution in the use of the plant-associated strain for a range of biotech applications. The genetic analysis was conducted in part at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory, and will be published in the July 2009 issue of Nature Reviews Microbiology, now available online.

16 Jun 2009

Scientists create simple chemical system that mimics DNA

A team of Scripps Research scientists has created a new analog to DNA that assembles and disassembles itself without the need for enzymes. Because the new system comprises components that might reasonably be expected in a primordial world, the new chemical system could answer questions about how life could emerge.

13 Jun 2009

Social moms make better moms, at least in baboons

Female baboons who have strong social relationships with other females give birth to offspring who are much more likely to survive to adulthood than baboons reared by less social mothers, according to a new study by researchers at the University of Pennsylvania, the University of California, Los Angeles, and others.

11 Jun 2009

New research looks at the role of geography in human adaptation

New research indicates that natural selection may shape the human genome much more slowly than previously thought. Other factors -- the movements of humans within and among continents, the expansions and contractions of populations, and the vagaries of genetic chance - have heavily influenced the distribution of genetic variations in populations around the world.

5 Jun 2009

New ‘molecular clock’ provides more accurate method of dating ancient human migration

Researchers at the University of Leeds have devised a more accurate method of dating ancient human migration - even when no corroborating archaeological evidence exists.

4 Jun 2009

Hydrogen peroxide marshals immune system

When you were a kid your mom poured it on your scraped finger to stave off infection. When you got older you might have even used it to bleach your hair. Now there's another possible function for this over-the-counter colorless liquid: your body might be using hydrogen peroxide as an envoy that marshals troops of healing cells to wounded tissue.

3 Jun 2009

Scientists create pig stem cells

Scientists have managed to induce cells from pigs to transform into pluripotent stem cells - cells that, like embryonic stem cells, are capable of developing into any type of cell in the body. It is the first time in the world that this has been achieved using somatic cells (cells that are not sperm or egg cells) from any animal with hooves (known as ungulates).

2 Jun 2009