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Immune system B-cells may be better in predicting HER2-positive breast cancer treatment response

Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have found that measuring activation of immune-system B cells may be better than measuring either T-cell activation or the total number of immune cells in and around a tumor, called tumor-infiltrating lymphocytes (TILs), in predicting whether HER2-positive breast cancer responds to treatment.

5 Jan 2023

Intestinal bacteria in multiple sclerosis patients vary with disease activity, study finds

Multiple sclerosis patients do not have the same bacteria in their intestines as healthy people. There are also differences in the composition and function of the bacteria in the intestines of multiple sclerosis patients, depending on whether their illness is active, and whether they are in treatment.

5 Jan 2023

What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity?

Researchers uncovered a novel mechanism that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses (CoVs) use to exploit host antiviral immune system to facilitate their replication.

5 Jan 2023

Does bimodal visual-olfactory training with patient-preferred scents improve olfaction in individuals with COVID-19 postviral olfactory loss?

Researchers investigated whether using patient-preferred scents and a bimodal method of visual-olfactory training is more effective than unimodal olfactory training using scents assigned by physicians in treating patients experiencing anosmia after COVID-19.

5 Jan 2023

What was the effect of the COVID-19 pandemic on the mental well-being of university students?

Researchers evaluated changes in the mental health status of university-attending students in France 15.0 months post-commencement of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

5 Jan 2023

Are patients with a history of MIS-C at increased risk of adverse reactions from COVID-19 vaccination?

Researchers investigated the reactogenicity of the COVID-19 vaccine in pediatric patients with MIS-C.

5 Jan 2023

Wayne State researcher wins $1.7 million NIH award to understand and tackle cisplatin-induced ototoxicity

A Wayne State University researcher has received a $1.7 million, five-year award from the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health for the study, "Targeting nitrative stress for treatment of cisplatin ototoxicity."

5 Jan 2023

SynGAP Research Fund awards $180,000 grant to the University of Edinburgh Medical School's Patrick Wild Centre & Centre for Discovery Brain Sciences

SynGAP Research Fund (SRF), a 501(c)(3) public charity whose mission is to improve the quality of life for SYNGAP1 patients through the research and development of treatments, therapies and support systems, along with SynGAP Research Fund UK, today announced they have awarded a $180,000 grant to the University of Edinburgh Medical School's Patrick Wild Centre & Centre for Discovery Brain Sciences to advance the science around gene transfer to correct SYNGAP1 haploinsufficiency.

5 Jan 2023

Seroprevalence study demonstrates vaccination could boost impaired humoral immunity against Omicron BQ.1.1 subvariant

Researchers conducted a multicenter, cross-sectional seroprevalence study in emergency departments of five hospitals in North Rhine-Westphalia, Germany, between August and September 2022. They assessed point seroprevalence and neutralization activity against Wu01, BA.4/5, and BQ.1.1.

5 Jan 2023

How does mindful attention change brain function to support self-regulation?

Researchers observed that mindful attention promoted control of brain network dynamics.

5 Jan 2023

New research extensively explores 12 distinctive aging traits

In a recent article published in Cell, researchers proposed that 12 distinctive traits of aging are all inter-related.

5 Jan 2023

Estimating the hospital costs associated with two of the most significant antibiotic-resistant organisms in Canada

Researchers assessed the hospital and associated resource costs related to AMR infections in Canada.

5 Jan 2023

Study shows angiotensin-converting enzyme 2 decoy protein as a promising anti-SARS-CoV-2 agent

Researchers presented a microbody recombinant decoy protein with high affinity to angiotensin-converting enzyme 2 (ACE2) as an option for coronavirus disease 2019 (COVID-19) treatment.

5 Jan 2023

How effective is the bivalent mRNA SARS-CoV-2 vaccine in preventing COVID-19 hospitalizations and deaths?

Researchers examined the effectiveness of the bivalent mRNA vaccine against severe outcomes of COVID-19.

5 Jan 2023

Trends in antibiotic resistance for the priority bacterial pathogens in children and adults

Researchers assessed the variation in antibiotic resistance patterns in adults and children.

5 Jan 2023

Acupuncture could be a safe and feasible management option for IBS-D

Researchers preliminarily evaluated the practicality of utilizing the United States (US) Food and Drug Administration (FDA)-advocated endpoints to assess the effectiveness of acupuncture in IBS-D (irritable bowel syndrome with diarrhea) management.

5 Jan 2023

Study assesses microbiome of male genital mucosa

A new study in the journal Microorganisms aimed to identify and analyze studies on the composition of the microbial community on different parts of the healthy and diseased male genital mucosa.

4 Jan 2023

Incurable liver disease could be reversed with a single drug

Research led by Associate Professor Duc Dong, Ph.D., has shown for the first time that the effects of Alagille syndrome, an incurable genetic disorder that affects the liver, could be reversed with a single drug.

4 Jan 2023

New dual-action, cancer-killing vaccine tested in an advanced mouse model of glioblastoma

Scientists are harnessing a new way to turn cancer cells into potent, anti-cancer agents. In the latest work from the lab of Khalid Shah, MS, PhD, at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, investigators have developed a new cell therapy approach to eliminate established tumors and induce long-term immunity, training the immune system so that it can prevent cancer from recurring.

4 Jan 2023

Researchers discover novel candidate drug targets for advanced non-alcoholic fatty liver disease

Using the latest technologies - including both single-nuclear sequencing of mice and human liver tissue and advanced 3D glass imaging of mice to characterize key scar-producing liver cells - researchers have uncovered novel candidate drug targets for non-alcoholic fatty liver disease (NAFLD).

4 Jan 2023

Medical Science News

Immune system B-cells may be better in predicting HER2-positive breast cancer treatment response

Intestinal bacteria in multiple sclerosis patients vary with disease activity, study finds

What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity?

Does bimodal visual-olfactory training with patient-preferred scents improve olfaction in individuals with COVID-19 postviral olfactory loss?

What was the effect of the COVID-19 pandemic on the mental well-being of university students?

Are patients with a history of MIS-C at increased risk of adverse reactions from COVID-19 vaccination?

Wayne State researcher wins $1.7 million NIH award to understand and tackle cisplatin-induced ototoxicity

SynGAP Research Fund awards $180,000 grant to the University of Edinburgh Medical School's Patrick Wild Centre & Centre for Discovery Brain Sciences

Seroprevalence study demonstrates vaccination could boost impaired humoral immunity against Omicron BQ.1.1 subvariant

How does mindful attention change brain function to support self-regulation?

New research extensively explores 12 distinctive aging traits

Estimating the hospital costs associated with two of the most significant antibiotic-resistant organisms in Canada

Study shows angiotensin-converting enzyme 2 decoy protein as a promising anti-SARS-CoV-2 agent

How effective is the bivalent mRNA SARS-CoV-2 vaccine in preventing COVID-19 hospitalizations and deaths?

Trends in antibiotic resistance for the priority bacterial pathogens in children and adults

Acupuncture could be a safe and feasible management option for IBS-D

Study assesses microbiome of male genital mucosa

Incurable liver disease could be reversed with a single drug

New dual-action, cancer-killing vaccine tested in an advanced mouse model of glioblastoma

Researchers discover novel candidate drug targets for advanced non-alcoholic fatty liver disease

How agentic AI is reshaping laboratory workflows

Fourier 80: bringing benchtop NMR systems to the laboratory

How industrial hygiene flow calibration supports defensible exposure data

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