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Researchers explore an inhalable SARS-CoV-2 nanobody therapy

Even as vaccines against SARS-CoV-2 are being developed and administered at an unprecedented pace, treating this infection remains a challenge. To address this, researchers from China have used nanobodies (Nb) as a possible therapeutic approach. They reported Nb phage display libraries derived from four camels immunized with the SARS-CoV-2 spike RBD.

12 Apr 2021

SARS-CoV-2 spike E484K mutation reduces antibody neutralization

Researchers at the Department of Microbiology, Icahn School of Medicine at Mount Sinai New York, USA, showed that the SARS-CoV-2 spike E484K mutation reduces antibody neutralization.

12 Apr 2021

Researchers identify several novel SARS-CoV-2 inhibitors

Researchers in London, UK, have identified several compounds with SARS-CoV-2 inhibiting properties, that potentially may be developed into antiviral solutions in the future.

9 Apr 2021

Researchers discover a new monoclonal antibody that is effective against SARS-CoV-2 variants

A new monoclonal antibody targets a particular region of the RBD on the SARS-CoV-2. This region is usually not accessible to immune cells, which may be why it has broad neutralizing capabilities.

9 Apr 2021

How has the COVID-19 pandemic affected sleep patterns for many US citizens?

A team of scientists recently conducted an online survey to examine the changes in sleep duration among adult US citizens during the COVID-19 pandemic.

9 Apr 2021

Autoantibodies may contribute to severe COVID-19 and potential long-COVID-19 symptoms

New research in the USA and China. investigated how autoantibodies could mediate NETs during a COVID-19 infection. Extensive damage to the body from neutrophil extracellular traps (NETs) after infection may be contributing to thromboinflammation and the symptoms experienced by COVID-19 ‘long-haulers’.

8 Apr 2021

Enhanced neutralization of SARS-CoV-2 South African variant with heterologous adjuvant vaccine candidate

A new study describes the use of a single dose of vaccine based on the viral protein called the receptor-binding domain (RBD) to elicit powerful neutralizing activity against both the Wuhan strain and the most concerning VOC called the South African (SA) strain.

7 Apr 2021

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

A team of scientists from the USA and Sweden has recently screened 8 million small molecule inhibitors against SARS-CoV-2.

5 Apr 2021

Research surveys hygiene practices in food supply chains during COVID-19 pandemic

Researchers survey hygiene procedures in food supply chains implemented during the COVID-19 pandemic.

5 Apr 2021

Muscle strength and mass may predict hospital stay duration in COVID-19 patients

Researchers found that COVID-19 patients with good muscle strength and higher muscle mass had a shorter stay in the hospital.

2 Apr 2021

Long-COVID-19 is a significant risk in recovered patients post-hospitalization

A new study, which appeared in the British Medical Journal, reports on a retrospective study to examine the incidence and risk factors for ‘long COVID-19’, the term used to describe the long-term effects of COVID-19 on affected individuals.

2 Apr 2021

Proper choice of control group nullifies most observed genetic markers for severe COVID-19, study suggests

A new study deals with the genetic contribution to severe disease following infection with this virus, showing that the association of severity with specific human genes described in an earlier study is not obvious.

2 Apr 2021

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

A new study describes the identification of new compounds from a library, with inhibitory activity against several coronaviruses. This study shows the utility of this method, besides identifying compounds that not only inhibit viral shedding in SARS-CoV-2 cultures, but have an immunomodulatory effect that may be useful in mitigating the damaging cytokine storm typical of severe or critical COVID-19.

2 Apr 2021

Comparative study of SARS, MERS, BAT‐SARS, and SARS-CoV-2

Even though a comparative study on the genomic sequences of SARS-CoV, MERS-CoV, and SARS-CoV-2 is available, there is a gap in the research in regards to the comparison between four types of coronaviruses, namely, SARS-CoV, MERS-CoV, BAT-CoV, and SARS-CoV-2. A new study, which deals with the genomic comparison between the sequence of the above-stated four types of coronaviruses, has been published in the Journal of Medical Virology.

2 Apr 2021

Study discovers new target on SARS-CoV-2 spike for protective antibodies

Researchers at The Scripps Research Institute, USA, have described a potential target for COVID-19 vaccines. Dubbed as CC40.8 bnAb, it exhibited broad reactivity with human beta coronaviruses.

1 Apr 2021

Can asymptomatic COVID-19 confer long-term immunity?

Researchers examined the antibody responses in symptomatic and asymptomatic individuals recovered from COVID-19 to see if there was a discernable difference in their humoral immune responses and long-term protection from reinfection with SARS-CoV-2.

1 Apr 2021

Researchers evaluate antibodies that inhibit SARS-CoV-2 RBD variants with a novel assay

A team of researchers recently discussed the potential role of a new assay in bridging a major gap in SARS-CoV-2 research. This assay can throw light on 1) the selection of complementary monoclonal antibody candidates and 2) rapid identification of the immune escape to emerging RBD variants following vaccination or natural infection.

31 Mar 2021

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is now established to be more likely to lead to symptomatic and serious illness in males relative to females. This may extend as far back as pregnancy, suggests a recent study.

31 Mar 2021

How has the COVID-19 pandemic impacted birth statistics in the U.S.?

A new study examines national-level changes in fertility, preterm birth and other obstetric outcomes, in the U.S., over the period of the pandemic throughout 2020.

29 Mar 2021

Study observes correlation between COVID-19 mortality and autoantibodies in corticosteroid treated patients

Corticosteroid anti-inflammatory drugs have been applied to COVID-19 patients over the course of the pandemic, though the results are mixed. In a recent study, the outcomes for such patients are collated, demonstrating a striking correlation between the development of autoantibodies and mortality.

25 Mar 2021

Miscellaneous News

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

SARS-CoV-2 spike E484K mutation reduces antibody neutralization

Researchers identify several novel SARS-CoV-2 inhibitors

Researchers discover a new monoclonal antibody that is effective against SARS-CoV-2 variants

How has the COVID-19 pandemic affected sleep patterns for many US citizens?

Autoantibodies may contribute to severe COVID-19 and potential long-COVID-19 symptoms

Enhanced neutralization of SARS-CoV-2 South African variant with heterologous adjuvant vaccine candidate

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

Research surveys hygiene practices in food supply chains during COVID-19 pandemic

Muscle strength and mass may predict hospital stay duration in COVID-19 patients

Long-COVID-19 is a significant risk in recovered patients post-hospitalization

Proper choice of control group nullifies most observed genetic markers for severe COVID-19, study suggests

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

Comparative study of SARS, MERS, BAT‐SARS, and SARS-CoV-2

Study discovers new target on SARS-CoV-2 spike for protective antibodies

Can asymptomatic COVID-19 confer long-term immunity?

Researchers evaluate antibodies that inhibit SARS-CoV-2 RBD variants with a novel assay

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

How has the COVID-19 pandemic impacted birth statistics in the U.S.?

Study observes correlation between COVID-19 mortality and autoantibodies in corticosteroid treated patients

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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