Molecular & Structural Biology

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Study provides better understanding of mechanisms that limit cilia number in cells

One of the wonders of cell biology is its symmetry. Mammalian cells have one nucleus and one cell membrane, and most humans have 23 pairs of chromosomes.

30 Dec 2019

A HSC surface marker plays key role in ontogeny of hematopoiesis

A group of researchers at Osaka University revealed that ESAM (Endothelial cell-selective adhesion molecule), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important role in the ontogeny of hematopoiesis in mice, particularly in the development of adult-type erythropoiesis.

26 Dec 2019

Researchers develop new approach for studying experience-driven activity of transcription factors

Our brains have a remarkable knack for adaptability. Each and every day the neuronal connections within are constantly changing, molded by what we experience in our daily lives.

26 Dec 2019

Inputs to the motor cortex can guide dexterous movements in mice

In a sleepy haze, reaching out and grabbing the coffee cup in front of you seems to happen on autopilot. But your caffeine-deprived brain is working hard.

26 Dec 2019

Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency

University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications.

23 Dec 2019

Ancestral-sequence reconstruction of FMO genes unveils structure of important enzyme

To disarm toxic substances, many organisms - including humans - possess enzymes called flavin-containing monooxygenases. Despite their importance, the structure of the enzymes has not been resolved, as the protein is too unstable to study in detail.

23 Dec 2019

New, faster and cheaper method to uncover genetic variants in single cells

Researchers led by the European Molecular Biology Laboratory in Heidelberg and the Center for Bioinformatics at Saarland University in Saarbrücken, Germany, have developed a cheaper and faster method to check for genetic differences in individual cells, which outperforms existing techniques with respect to the information received.

23 Dec 2019

Researchers develop powerful computer algorithm for large-scale genomic analysis

Haplotypes are a set of genetic variations that, located side by side on the same chromosome, are transmitted in a single group to the next generation. Their examination makes it possible to understand the heritability of certain complex traits, such as the risk of developing a disease.

20 Dec 2019

Using artificial intelligence to disassemble hunting behavior of zebrafish into its components

What is the common ground between making a cup of tea and putting on your shoes? Both actions consist of several movements in a row.

20 Dec 2019

p53 may play a more important role in kidney cancer than previously thought

The p53 gene, which researchers had thought was less relevant in kidney cancer, may play an important role after all – a discovery that could lead to new treatments.

20 Dec 2019

Atomic-level structure of cardiac sodium channel

Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, disruption by many disease mutations, and response to medication.

20 Dec 2019

Study reveals new role for a triple-negative breast cancer target

Unlike almost every other organ, the mammary gland does not develop until after birth. And it's unusually dynamic, shape-shifting during menstrual cycles, puberty, pregnancy, and lactation.

19 Dec 2019

Scientists create new classification system for tumors

Based on the largest study of cancer patients of its kind, scientists have created a new way of classifying tumors.

19 Dec 2019

Observing 3D Microscopic Images using Virtual Reality

Dr. Christopher Zugates discusses a revolutionary way of analyzing complex 3D images in protein biology… through virtual reality!

From arivis AG 19 Dec 2019

Different mutations in a single gene can have myriad effects on a person's health

Mount Sinai researchers have found that different mutations in a single gene can have myriad effects on a person's health, suggesting that gene therapies may need to do more than just replenish the missing or dysfunctional protein the gene is supposed to encode, according to a study published in Nature Genetics in November.

18 Dec 2019

Researchers identify frequent technical bias in data generated by RNA-seq technology

Reproducibility of research data is a major challenge in experimental biology. As data generated by genomic-scale techniques increases in complexity, this concern is becoming more and more worrisome.

18 Dec 2019

Researchers identify novel genetic signature with prognostic value for certain breast cancers

Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases.

17 Dec 2019

Molecular & Structural Biology

Study provides better understanding of mechanisms that limit cilia number in cells

A HSC surface marker plays key role in ontogeny of hematopoiesis

Researchers develop new approach for studying experience-driven activity of transcription factors

Inputs to the motor cortex can guide dexterous movements in mice

Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency

Ancestral-sequence reconstruction of FMO genes unveils structure of important enzyme

New, faster and cheaper method to uncover genetic variants in single cells

Researchers develop powerful computer algorithm for large-scale genomic analysis

Using artificial intelligence to disassemble hunting behavior of zebrafish into its components

p53 may play a more important role in kidney cancer than previously thought

Atomic-level structure of cardiac sodium channel

Study reveals new role for a triple-negative breast cancer target

Scientists create new classification system for tumors

Observing 3D Microscopic Images using Virtual Reality

Different mutations in a single gene can have myriad effects on a person's health

Researchers identify frequent technical bias in data generated by RNA-seq technology

Researchers identify novel genetic signature with prognostic value for certain breast cancers

High-fat meal can silence gut's communication with the body, study shows

Brazilian researchers create hepatic organoids by 3D bioprinting

Using bacterial nano-syringes as drug transporters in medicine

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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