Molecular & Structural Biology

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Applying a Proteomics-based Approach to the Clinic

Matthias Mann explains why applying proteomics-based technologies such as timsTOF could accelerate the diagnosis and prediction of human disease.

From Bruker Life Sciences Mass Spectrometry 20 Nov 2019

New database helps identify therapeutic targets to fight infectious diseases

Infectious diseases are caused by pathogenic microorganisms capable of entering, colonizing and growing within a host organism, thus producing an infection. Bacterial infections have been on the rise worldwide in recent years, but many mechanisms underlying bacterial pathogenesis are still poorly understood.

19 Nov 2019

Scientists grow complex organoids in the lab

Scientists at the University of Würzburg have successfully produced human tissues from stem cells. They have a complexity similar to that of normal tissue and are far superior to previous structures.

19 Nov 2019

Research findings can be used in antiviral development against enterovirus infections

Despite their prevalence, there are no antivirals on the market against enteroviruses, and vaccines have been developed only against couple of serotypes. The production of vaccines against all enterovirus serotypes is not feasible, and so antiviral drugs may be the solution for most of the enterovirus infections.

19 Nov 2019

TARA's organ-on-a-chip technology can directly measure in vivo cardiac performance, study shows

TARA Biosystems, Inc. today reported in vivo and in vitro functional data from a study of investigational candidate, MYK-491, showing that TARA's human iPSC-derived organ-on-a-chip technology can directly measure in vivo cardiac performance.

18 Nov 2019

Study uncovers how the molecule-sorting station in our cells is formed and maintained

The cells in our body are workshops that continuously operate to produce and process substances to keep us going. When a substance enters a cell for processing, it is surrounded by a portion of the cell's outer membrane to form a sac.

15 Nov 2019

Researchers decode molecular structure of cytochrome bd oxidase from E. coli

Both humans and many other creatures need oxygen for survival. In the conversion of nutrients into energy, the oxygen is converted to water, for which the enzyme oxidase is responsible. It represents the last step of the so-called respiratory chain.

14 Nov 2019

New technique enables the study of transporter proteins at a single-molecule level

Like a boat helping passengers cross a river, transporters move substances across cell membranes. This process is fundamental to the healthy functioning of cells in life forms from bacteria to humans.

14 Nov 2019

Crick study reveals vital protective role of telomere t-loops

Loops at the ends of telomeres play a vital protective role preventing irretrievable damage to chromosomes, according to new research from the Crick.

From The Francis Crick Institute 12 Nov 2019

Scientists publish structural and functional keys that distinguish two similar transcription factors

Scientists at the Institute for Research in Biomedicine, in collaboration with the Sloan Kettering Institute (New York, US), have published the structural and functional keys that distinguish two very similar transcription factors, namely SMAD2 and SMAD3.

12 Nov 2019

Compound that may help delay onset of Alzheimer’s can be produced in baker’s yeast

Scientists prove that ergothioneine, an important compound that may be used to delay the onset of diseases such as Alzheimer’s and dementia, can be produced in baker’s yeast.

11 Nov 2019

Study shows how glucocorticoid hormones control sugar and fat levels over the course of 24 hours

For the first time, a study led by researchers at Helmholtz Zentrum München and the German Center for Diabetes Research shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course of 24 hours.

10 Nov 2019

Musical pleasure linked to right combination of uncertainty and surprise

Why is it that people find songs such as James Taylor's "Country Roads," UB40's "Red, Red Wine," or The Beatles' "Ob-La-Di, Ob-La-Da" so irresistibly enjoyable? In a study reported in the journal Current Biology on November 7, researchers analyze 80,000 chords in 745 classic U.S. Billboard pop songs--including those three--and find that musical pleasure comes from the right combination of uncertainty and surprise.

8 Nov 2019

Humans can have normal olfaction without typical olfactory bulbs

Our sense of smell depends on the transmission of olfactory information from the nose to the olfactory bulb in the brain through the olfactory nerve. And without olfactory bulbs, smell isn't possible--or so scientists thought.

8 Nov 2019

Understanding Monoclonal Antibody Unfolding and Aggregation

A therapeutic monoclonal antibody and its Fab and Fc fragments were recently investigated using differential scanning fluorimetry, temperature-ramped dynamic light scattering, and turbidity measurements.

From Waters | Wyatt Technology 8 Nov 2019

Researchers join forces to adapt novel genetic tool for zoonotic Chlamydia

The human pathogenic bacterium Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen worldwide.

7 Nov 2019

UVA scientists develop a better way to determine what our genes do

Scientists at the University of Virginia School of Medicine have developed a better way to determine what our genes do – allowing scientists to better probe the genetic causes of diseases and more efficiently determine whether new drugs will act on the intended target exactly as needed.

7 Nov 2019

New study sheds light on how memories are formed

How does the brain translate information from the outside world into something we remember? An international team of researchers working in the Human Brain Project have zoomed in on the neuronal circuits in the striatum, a brain structure involved in memory, behavior and reward learning.

7 Nov 2019

Integrating European life sciences in the area of imaging

The European Commission has officially established Euro-BioImaging - which provides life scientists with open access to a broad range of technologies and resources in biological and biomedical imaging - as a European Research Infrastructure Consortium.

7 Nov 2019

NJIT professor receives Fulbright U.S. Scholar Award, joins circadian clock research project

Casey Diekman, associate professor of mathematics at New Jersey Institute of Technology (NJIT), has been named recipient of a prestigious Fulbright U.S. Scholar Program Award to the United Kingdom in Mathematical Biology.

6 Nov 2019

Molecular & Structural Biology

Applying a Proteomics-based Approach to the Clinic

New database helps identify therapeutic targets to fight infectious diseases

Scientists grow complex organoids in the lab

Research findings can be used in antiviral development against enterovirus infections

TARA's organ-on-a-chip technology can directly measure in vivo cardiac performance, study shows

Study uncovers how the molecule-sorting station in our cells is formed and maintained

Researchers decode molecular structure of cytochrome bd oxidase from E. coli

New technique enables the study of transporter proteins at a single-molecule level

Crick study reveals vital protective role of telomere t-loops

Scientists publish structural and functional keys that distinguish two similar transcription factors

Compound that may help delay onset of Alzheimer’s can be produced in baker’s yeast

Study shows how glucocorticoid hormones control sugar and fat levels over the course of 24 hours

Musical pleasure linked to right combination of uncertainty and surprise

Humans can have normal olfaction without typical olfactory bulbs

Understanding Monoclonal Antibody Unfolding and Aggregation

Researchers join forces to adapt novel genetic tool for zoonotic Chlamydia

UVA scientists develop a better way to determine what our genes do

New study sheds light on how memories are formed

Integrating European life sciences in the area of imaging

NJIT professor receives Fulbright U.S. Scholar Award, joins circadian clock research project

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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