Molecular & Structural Biology

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Nerve cell protection without side effects on erythropoiesis

The hormone erythropoietin (Epo) is a well-known doping substance that has a long history of abuse in endurance sports, such as cycling. In addition to promoting red blood cell production (erythropoiesis), which improves the oxygen supply in the organism, Epo also protects nerve cells from cell death.

25 Oct 2019

Researchers unveil ultrastructure of focal adhesion scaffold in pluripotent stem cells

Focal adhesions are known as signaling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signaling cascades.

25 Oct 2019

Study finds molecular key to formation of mature and fully functioning T cells

In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.

25 Oct 2019

Researchers discover how the body repairs damaged DNA

Researchers from the University of Copenhagen have made an extraordinary discovery in how the body repairs damaged DNA, which can lead to better understanding and management of diseases such as cancer.

25 Oct 2019

Researchers use 3D electron microscopy to unravel dense networks in the cerebral cortex

Unlike any other organ, our brains contain extremely densely packed networks of membranous cables that are used by our about 86 billion nerve cells for communication amongst each other.

24 Oct 2019

Scientists pinpoint epigenetic differences in the way lupus affects black women

Scientists at the HudsonAlpha Institute for Biotechnology have pinpointed epigenetic differences in the way lupus affects black women compared to other lupus patients, revealing important mechanics of the puzzling disease.

24 Oct 2019

Insights about the sweet receptor could lead to better-tasting food

Whether it's chocolate cake or pasta sauce, the sensation of sweetness plays a major role in the human diet and the perception of other flavors.

24 Oct 2019

Parents' behavior can have substantial impact on developing oxytocin systems in babies

Oxytocin is an extremely important hormone, involved in social interaction and bonding in mammals, including humans.

24 Oct 2019

Molecular processes underlying communication between gut microbes and brain cells revealed

New cellular and molecular processes underlying communication between gut microbes and brain cells have been described for the first time by scientists at Weill Cornell Medicine and Cornell's Ithaca campus.

23 Oct 2019

Research suggests greater complexity in cellular protein movement

A new imaging technique that makes it possible to match motor proteins with the cargo they carry within a cell is upending a standard view of how cellular traffic reaches the correct destination.

23 Oct 2019

Study uses baker's yeast to show how genes interact to influence a surprising cellular outcome

Most diseases are complex--caused by faults in multiple genes--but studying how combinations of different genetic variants affect cellular traits is challenging.

23 Oct 2019

Study shows how cell competition corrects noisy morphogen gradients during embryogenesis

Tissue patterning is an important process during embryo formation, as well in adult tissue, which ensures that groups of cells are correctly arranged to allow them to function properly.

23 Oct 2019

New research challenges the traditional understanding of cellular sleep

A University of Arizona-led research team challenged the traditional understanding of cellular sleep and discovered new information that could lead to interventions in the aging process.

22 Oct 2019

Study shows how mouse X and Y chromosomes compete with each other to control sex of offspring

The molecular function of genes in mice has a major influence on the sex of their offspring, according to a new discovery that reveals more about the impact of genes on animal fertility.

21 Oct 2019

Columbia researchers capture new detailed images of a temperature-sensing molecule

Columbia University researchers have captured new detailed images of a temperature-sensing molecule in its open, intermediate, and closed states.

21 Oct 2019

Link found between genetic variations and size of the brainstem, other subcortical structures

Researchers have found a link between 48 common genetic variations and the size of the brainstem and other subcortical structures deep within the brain.

21 Oct 2019

SciLifeLab and AstraZeneca establish cryo-EM collaboration to advance biomedicine

The study published in Science Advances reveals the mechanism by which the receptor tyrosine kinase RET can increase neuronal survival in degenerative diseases. To understand the mechanism of this signaling complex, the researchers solved the cryo-EM structure of its extracellular region, employing a new approach for data collection.

21 Oct 2019

Salk scientists receive NIH funding to map brain circuitry for movement

A team of Salk scientists led by Professor Martyn Goulding has been awarded $14.3 million over five years by the National Institutes of Health to create a high-resolution atlas of how the mouse brain generates and controls skilled forelimb movements, such as reaching and grasping.

18 Oct 2019

'Flamenco-style' dancing molecule could form the basis for new longer-lasting sunscreen

A molecule that protects plants from overexposure to harmful sunlight thanks to its flamenco-style twist could form the basis for a new longer-lasting sunscreen, chemists at the University of Warwick have found, in collaboration with colleagues in France and Spain.

18 Oct 2019

Building models to reconstruct evolutionary change more accurately than ever before

Remember domain, kingdom, phylum, class, order, family, genus, species and Darwin's tree of life metaphor we learned about in high school biology? That way of describing living-things lineages is just science's best guess about how genes have mutated and split over time to change things into what they are today.

17 Oct 2019

Molecular & Structural Biology

Nerve cell protection without side effects on erythropoiesis

Researchers unveil ultrastructure of focal adhesion scaffold in pluripotent stem cells

Study finds molecular key to formation of mature and fully functioning T cells

Researchers discover how the body repairs damaged DNA

Researchers use 3D electron microscopy to unravel dense networks in the cerebral cortex

Scientists pinpoint epigenetic differences in the way lupus affects black women

Insights about the sweet receptor could lead to better-tasting food

Parents' behavior can have substantial impact on developing oxytocin systems in babies

Molecular processes underlying communication between gut microbes and brain cells revealed

Research suggests greater complexity in cellular protein movement

Study uses baker's yeast to show how genes interact to influence a surprising cellular outcome

Study shows how cell competition corrects noisy morphogen gradients during embryogenesis

New research challenges the traditional understanding of cellular sleep

Study shows how mouse X and Y chromosomes compete with each other to control sex of offspring

Columbia researchers capture new detailed images of a temperature-sensing molecule

Link found between genetic variations and size of the brainstem, other subcortical structures

SciLifeLab and AstraZeneca establish cryo-EM collaboration to advance biomedicine

Salk scientists receive NIH funding to map brain circuitry for movement

'Flamenco-style' dancing molecule could form the basis for new longer-lasting sunscreen

Building models to reconstruct evolutionary change more accurately than ever before

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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