Molecular & Structural Biology

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Scientists show how protein Ikaros orchestrates fine balance to control autoimmunity

The immune system relies on B cells and their ability to make antibodies against an extremely broad range of pathogens. This broad responsiveness bears some risk, as B cells can also turn against healthy tissue - a phenomenon called autoimmunity.

8 Oct 2019

Criticality is a hallmark of normally functioning brain networks, research shows

Researchers long wondered how the billions of independent neurons in the brain come together to reliably build a biological machine that easily beats the most advanced computers. All of those tiny interactions appear to be tied to something that guarantees an impressive computational capacity.

8 Oct 2019

New protein painting technology could transform drug discovery process

George Mason University researchers have discovered the exact location where two proteins responsible for hiding cancer cells from the immune system bind.

8 Oct 2019

Common genetic variant explains why immunotherapy often fails in Crohn's disease

The reason why a commonly used range of immunotherapy drugs is not effective in some patients with Crohn’s disease has so far not been identified, until now.

7 Oct 2019

Video images offer real-time view into the kinetics of viral assembly

For the first time, researchers have captured images of the formation of individual viruses, offering a real-time view into the kinetics of viral assembly. The research provides new insights into how to fight viruses and engineer self-assembling particles.

4 Oct 2019

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

Investigation of biological mechanisms in urothelial tissue -one of the three types of tissue that make up the urinary system- has always been very limited due to the lack of technologies that allow working with stable and long-term populations of the cells that compose it.

4 Oct 2019

Stanford study finds genetic similarities among species that use sound waves to navigate

Insect-eating bats navigate effortlessly in the dark and dolphins and killer whales gobble up prey in murky waters thanks in part to specific changes in a set of 18 genes involved in the development of the cochlear ganglion -- a group of nerves that transmit sound from the ear to the brain, according to a study by researchers at Stanford University.

4 Oct 2019

Researchers develop 3D tissue models of brain tumors in a brain-mimicking microenvironment

A team of Tufts University-led researchers has developed three-dimensional human tissue culture models of pediatric and adult brain cancers in a brain-mimicking microenvironment, a significant advancement for the study of brain tumor biology and pharmacological response.

4 Oct 2019

The atomic-level structure of DNA polymerase delta – the enzyme behind DNA replication

A new study has revealed how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that can be transmitted through the generations.

4 Oct 2019

Rapid progress in brain organoid research prompts ethical debate

A new paper has tried to address the ethical debate surrounding human organoids by evaluating the potential risks of creating “humanized” animals

4 Oct 2019

Mount Sinai researchers discover how DNA polymerase delta duplicates the genome

Mount Sinai researchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to the next. In a study published in Nature Structural & Molecular Biology, the team also reported how certain mutations can modulate the activity of this enzyme, leading to cancers and other diseases.

3 Oct 2019

Novel viral vector improves gene therapy for sickle cell disease

Researchers at the National Institutes of Health (NIH) have developed a unique, improved lentiviral vector for use in gene therapy for sickle cell disease.

3 Oct 2019

Fighting for Change: Detecting Fraudulent Honey using NMR

In this interview, Peter Awram discusses the benefits of NMR spectroscopy as an analytical technique for the honey industry, in the fight against fraud.

From Bruker BioSpin - NMR, EPR and Imaging 2 Oct 2019

Researchers observe the effects of two proteins responsible for metastasis

The research by Assoc. Prof. Nurhan özlü of Koç University Department of Molecular Biology and Genetics and her team recently published in Molecular & Cellular Proteomics has observed the effects of two proteins in the transition from the epithelial to the mesenchymal cell type, the latter of which has mobility.

2 Oct 2019

US Government to fund development of a 'universal flu vaccine'

The US government is to provide up to 400 million USD in funding to develop a “universal” flu vaccination at Duke University over the next seven years.

1 Oct 2019

New method for studying individual cells could lead to earlier detection of diseases

Researchers in Sweden and the U.S. have devised a new method for studying individual cells in human tissue, which could lead to even earlier detection of diseases such as cancer and ALS. The method offers a 1,400-fold increase in spatial resolution.

1 Oct 2019

Research reveals new mechanism which could lead to premature aging in mother cells

Researchers from the University of Seville and the Andalusian Center of Molecular Biology and Regenerative Medicine, have discovered a new mechanism that makes it possible to understand premature aging in cells with asymmetrical cell division, as is the case with mother cells.

30 Sep 2019

Molecular & Structural Biology

Scientists show how protein Ikaros orchestrates fine balance to control autoimmunity

Criticality is a hallmark of normally functioning brain networks, research shows

New protein painting technology could transform drug discovery process

Common genetic variant explains why immunotherapy often fails in Crohn's disease

Video images offer real-time view into the kinetics of viral assembly

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

Stanford study finds genetic similarities among species that use sound waves to navigate

Researchers develop 3D tissue models of brain tumors in a brain-mimicking microenvironment

The atomic-level structure of DNA polymerase delta – the enzyme behind DNA replication

Rapid progress in brain organoid research prompts ethical debate

Mount Sinai researchers discover how DNA polymerase delta duplicates the genome

Novel viral vector improves gene therapy for sickle cell disease

Fighting for Change: Detecting Fraudulent Honey using NMR

Researchers observe the effects of two proteins responsible for metastasis

US Government to fund development of a 'universal flu vaccine'

New method for studying individual cells could lead to earlier detection of diseases

Research reveals new mechanism which could lead to premature aging in mother cells

Cellular aging associated with structural changes in the brain

Functional three-organoid stem cell system could lead to unprecedented advances for precision medicine

Scientists use ultrasound to detect active genes in live cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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